BURS_ANOGA
ID BURS_ANOGA Reviewed; 163 AA.
AC Q66Q82; A7USU8;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Bursicon;
DE AltName: Full=Bursicon subunit alpha;
DE AltName: Full=Cuticle-tanning hormone;
DE Flags: Precursor;
GN Name=burs124;
GN and
GN Name=burs3; ORFNames=AGAP002537;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TRANS-SPLICING.
RX PubMed=17435221; DOI=10.1534/genetics.107.070938;
RA Robertson H.M., Navik J.A., Walden K.K.O., Honegger H.-W.;
RT "The bursicon gene in mosquitoes: an unusual example of mRNA trans-
RT splicing.";
RL Genetics 176:1351-1353(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Final heterodimeric neurohormone released at the end of the
CC molting cycle, involved in the sclerotization (tanning) of the insect
CC cuticle, melanization and wing spreading.
CC {ECO:0000250|UniProtKB:Q9VD83}.
CC -!- SUBUNIT: Heterodimer of burs and pburs. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- MISCELLANEOUS: The bursicon gene is encoded by two loci: burs124 on
CC chromosome arm 2L contains exons 1, 2 and 4, and burs3 on arm 2R
CC contains exon 3. Exon 3 is trans-spliced into position in the mature
CC transcript. This unusual gene arrangement has existed for at least the
CC 150 million years (MY) of mosquito evolution since the split of the
CC culicid and anophelid family lineages, but is younger than the 250 MY
CC split of the dipteran suborders Nematocera and Brachycera (containing
CC the Culicidea and Drosophilidae, respectively).
CC -!- SEQUENCE CAUTION:
CC Sequence=EDO64233.1; Type=Erroneous gene model prediction; Note=AAAB01008859 carries exon 3.; Evidence={ECO:0000305};
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DR EMBL; AY735442; AAU08017.1; -; mRNA.
DR EMBL; AY735443; AAU08018.1; -; mRNA.
DR EMBL; AAAB01008859; EDO64233.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AAAB01008900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001688381.1; XM_001688329.1.
DR AlphaFoldDB; Q66Q82; -.
DR STRING; 7165.AGAP002537-PA; -.
DR GeneID; 5667449; -.
DR KEGG; aga:AgaP_AGAP002537; -.
DR CTD; 5667449; -.
DR VEuPathDB; VectorBase:AGAP002537; -.
DR eggNOG; KOG1216; Eukaryota.
DR HOGENOM; CLU_2339394_0_0_1; -.
DR InParanoid; Q66Q82; -.
DR OrthoDB; 1517793at2759; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR Pfam; PF03045; DAN; 1.
DR PROSITE; PS01225; CTCK_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..163
FT /note="Bursicon"
FT /id="PRO_0000223886"
FT DOMAIN 39..129
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 39..88
FT /evidence="ECO:0000250|UniProtKB:P04275,
FT ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 53..102
FT /evidence="ECO:0000250|UniProtKB:P04275,
FT ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 63..123
FT /evidence="ECO:0000250|UniProtKB:P04275,
FT ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 67..125
FT /evidence="ECO:0000250|UniProtKB:P04275,
FT ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 85..128
FT /evidence="ECO:0000250|UniProtKB:P04275,
FT ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 87
FT /note="Interchain"
FT /evidence="ECO:0000250|UniProtKB:P04275,
FT ECO:0000255|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 163 AA; 18067 MW; 98C9E30848838FBC CRC64;
MKSTFLVVLE LAFFLLPGRV LYAQKDSEDG GSHYSSDDCQ VTPVIHVLQY PGCVPKPIPS
FACIGRCASY IQVSGSKIWQ MERSCMCCQE SGEREASVSL FCPKAKNGEK KFRKVSTKAP
LECMCRPCTG IEDANVIPQE LTSFADEGTL TGYFQKSHYK SIE
