ID   BURS_BOMMO              Reviewed;         160 AA.
AC   Q566B1;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Bursicon;
DE   AltName: Full=Bursicon subunit alpha;
DE   AltName: Full=Cuticle-tanning hormone;
DE   Flags: Precursor;
GN   Name=burs {ECO:0000250|UniProtKB:Q9VD83};
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=p50T {ECO:0000269|PubMed:15141943};
RX   PubMed=15141943; DOI=10.1093/dnares/11.1.27;
RA   Mita K., Kasahara M., Sasaki S., Nagayasu Y., Yamada T., Kanamori H.,
RA   Namiki N., Kitagawa M., Yamashita H., Yasukochi Y., Kadono-Okuda K.,
RA   Yamamoto K., Ajimura M., Ravikumar G., Shimomura M., Nagamura Y.,
RA   Shin-I T., Abe H., Shimada T., Morishita S., Sasaki T.;
RT   "The genome sequence of silkworm, Bombyx mori.";
RL   DNA Res. 11:27-35(2004).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:CAH89262.2}
RP   IDENTIFICATION.
RX   PubMed=15811337; DOI=10.1016/j.febslet.2005.03.006;
RA   Mendive F.M., Van Loy T., Claeysen S., Poels J., Williamson M., Hauser F.,
RA   Grimmelikhuijzen C.J.P., Vassart G., Vanden Broeck J.J.M.;
RT   "Drosophila molting neurohormone bursicon is a heterodimer and the natural
RT   agonist of the orphan receptor DLGR2.";
RL   FEBS Lett. 579:2171-2176(2005).
CC   -!- FUNCTION: Final heterodimeric neurohormone released at the end of the
CC       molting cycle, involved in the sclerotization (tanning) of the insect
CC       cuticle, melanization and wing spreading.
CC       {ECO:0000250|UniProtKB:Q9VD83}.
CC   -!- SUBUNIT: Heterodimer of burs and pburs. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; BAAB01143969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BN000691; CAH89262.2; -; mRNA.
DR   RefSeq; NP_001091845.1; NM_001098375.1.
DR   AlphaFoldDB; Q566B1; -.
DR   STRING; 7091.BGIBMGA011022-TA; -.
DR   GeneID; 100049169; -.
DR   KEGG; bmor:100049169; -.
DR   CTD; 42560; -.
DR   eggNOG; KOG0029; Eukaryota.
DR   eggNOG; KOG1216; Eukaryota.
DR   InParanoid; Q566B1; -.
DR   OrthoDB; 1517793at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   Pfam; PF03045; DAN; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..160
FT                   /note="Bursicon"
FT                   /id="PRO_0000223887"
FT   DOMAIN          38..131
FT                   /note="CTCK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        41..90
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        55..104
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        65..125
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        69..127
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        87..130
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        89
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
SQ   SEQUENCE   160 AA;  17901 MW;  B3D33F0E16FD4961 CRC64;
     MSVLNTFLVI VALILCYVND FPVTGHEVQL PPGTKFFCQE CQMTAVIHVL KHRGCKPKAI
     PSFACIGKCT SYVQVSGSKI WQMERTCNCC QESGEREATV VLFCPDAQNE EKRFRKVSTK
     APLQCMCRPC GSIEESSIIP QEVAGYSEEG PLYNHFRKSL