ID   BURS_MANSE              Reviewed;         156 AA.
AC   Q4FCM6;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Bursicon;
DE   AltName: Full=Bursicon subunit alpha;
DE   AltName: Full=Cuticle-tanning hormone;
DE   Flags: Precursor;
GN   Name=burs {ECO:0000312|EMBL:AAZ04374.1};
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1] {ECO:0000312|EMBL:AAZ04374.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Dewey E.M., Honegger H.-W.;
RT   "Identification of the Manduca sexta burs cDNA using RACE PCR.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Final heterodimeric neurohormone released at the end of the
CC       molting cycle, involved in the sclerotization (tanning) of the insect
CC       cuticle, melanization and wing spreading.
CC       {ECO:0000250|UniProtKB:Q9VD83}.
CC   -!- SUBUNIT: Heterodimer of burs and pburs. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; DQ094149; AAZ04374.1; -; mRNA.
DR   AlphaFoldDB; Q4FCM6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   Pfam; PF03045; DAN; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..156
FT                   /note="Bursicon"
FT                   /id="PRO_0000223888"
FT   DOMAIN          37..127
FT                   /note="CTCK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        37..86
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        51..100
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        61..121
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        65..123
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        83..126
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        85
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250|UniProtKB:P04275,
FT                   ECO:0000255|PROSITE-ProRule:PRU00039"
SQ   SEQUENCE   156 AA;  17659 MW;  726CACD0E5E2E093 CRC64;
     MYALDFLFIA FVYFAACHIQ EKPVRAQEVQ LPPGQECQMT PVIHILKHRG CKPKAIPSFA
     CIGKCTSYVQ VSGSKIWQME RTCNCCQEAG EREATVVLYC PDAKNEERRF RKVSTKAPLE
     CMCRPCGSIE ESAIIPQEVA GYAEEGPLYN HFRKSF