BUT1_SCHPO
ID BUT1_SCHPO Reviewed; 243 AA.
AC O42666; Q4F7X3;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 3.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Uba3-binding protein but1;
DE AltName: Full=Meiotically up-regulated gene 107 protein;
GN Name=but1; Synonyms=mug107; ORFNames=SPAC27D7.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH BUT2 AND
RP UBA3, AND SUBCELLULAR LOCATION.
RX PubMed=14623327; DOI=10.1016/j.bbrc.2003.10.058;
RA Yashiroda H., Tanaka K.;
RT "But1 and But2 proteins bind to Uba3, a catalytic subunit of E1 for
RT neddylation, in fission yeast.";
RL Biochem. Biophys. Res. Commun. 311:691-695(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Kang K.-Y., Lim H.-W., Lim C.-J.;
RT "Cloning and characterization of a peroxiredoxin (Prx) gene from
RT Schizosaccharomyces pombe.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [4]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Acts as a negative regulator of the NEDD8 pathway. Has a role
CC in meiosis. {ECO:0000269|PubMed:14623327, ECO:0000269|PubMed:16303567}.
CC -!- SUBUNIT: Homodimer. Interacts with but2 and uba3.
CC {ECO:0000269|PubMed:14623327}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14623327,
CC ECO:0000269|PubMed:16823372}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAZ16240.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BR000027; FAA00001.1; -; Genomic_DNA.
DR EMBL; DQ104735; AAZ16240.1; ALT_INIT; Genomic_DNA.
DR EMBL; CU329670; CAF02013.1; -; Genomic_DNA.
DR PIR; T38445; T38445.
DR RefSeq; NP_001018283.1; NM_001020046.2.
DR AlphaFoldDB; O42666; -.
DR SMR; O42666; -.
DR BioGRID; 280479; 22.
DR STRING; 4896.SPAC27D7.12c.1; -.
DR PaxDb; O42666; -.
DR EnsemblFungi; SPAC27D7.12c.1; SPAC27D7.12c.1:pep; SPAC27D7.12c.
DR GeneID; 3361403; -.
DR KEGG; spo:SPAC27D7.12c; -.
DR PomBase; SPAC27D7.12c; but1.
DR VEuPathDB; FungiDB:SPAC27D7.12c; -.
DR eggNOG; KOG0852; Eukaryota.
DR HOGENOM; CLU_1176008_0_0_1; -.
DR PRO; PR:O42666; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0008379; F:thioredoxin peroxidase activity; IMP:PomBase.
DR GO; GO:0061692; P:cellular detoxification of hydrogen peroxide; IMP:PomBase.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IMP:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR000866; AhpC/TSA.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF00578; AhpC-TSA; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW Meiosis; Nucleus; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..243
FT /note="Uba3-binding protein but1"
FT /id="PRO_0000065025"
FT REGION 28..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 243 AA; 27418 MW; 379AC0B9C7C20DB5 CRC64;
MEIDQNLFQF PISTRDAVHE KNCTLRVKST KKRRSSTKDE ETRGMHPHIK SSFRNGMNHA
RVIREEDMEV VFEPCFINLS KPVYVVNGIG GINEIHKLPI LFSSFVLCFF GNVSGDYGYV
DNVPLHISVI SHFYPCLQSY NTDVIGITTD TVENICQWKA HLPRALQFSL PVISDSNNEI
CREMGMLHPL GGAKLALDAI VIIDSIGRRR DILPIRTTTC VSTLITAVQE TVRFLAIENG
RLL
