ID   BVGA_BORPA              Reviewed;         209 AA.
AC   P0A4H4; P16574;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Virulence factors putative positive transcription regulator BvgA;
GN   Name=bvgA; OrderedLocusNames=BPP3028;
OS   Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9305;
RX   PubMed=1791760; DOI=10.1111/j.1365-2958.1991.tb02093.x;
RA   Arico B., Scarlato V., Monack D.M., Falkow S., Rappuoli R.;
RT   "Structural and genetic analysis of the bvg locus in Bordetella species.";
RL   Mol. Microbiol. 5:2481-2491(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12822 / ATCC BAA-587 / NCTC 13253;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
RX   PubMed=1791761; DOI=10.1111/j.1365-2958.1991.tb02094.x;
RA   Scarlato V., Prugnola A., Arico B., Rappuoli R.;
RT   "The bvg-dependent promoters show similar behaviour in different Bordetella
RT   species and share sequence homologies.";
RL   Mol. Microbiol. 5:2493-2498(1991).
CC   -!- FUNCTION: Member of the two-component regulatory system BvgS/BvgA.
CC       Activates the transcription of virulence genes.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- PTM: Phosphorylated by BvgS. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE38318.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X52948; CAA37123.1; -; Genomic_DNA.
DR   EMBL; BX640432; CAE38318.1; ALT_INIT; Genomic_DNA.
DR   PIR; S17945; S17945.
DR   RefSeq; WP_010930609.1; NC_002928.3.
DR   AlphaFoldDB; P0A4H4; -.
DR   SMR; P0A4H4; -.
DR   EnsemblBacteria; CAE38318; CAE38318; BPP3028.
DR   GeneID; 56479102; -.
DR   KEGG; bpa:BPP3028; -.
DR   HOGENOM; CLU_000445_90_1_4; -.
DR   Proteomes; UP000001421; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system; Virulence.
FT   CHAIN           1..209
FT                   /note="Virulence factors putative positive transcription
FT                   regulator BvgA"
FT                   /id="PRO_0000081033"
FT   DOMAIN          4..119
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          142..207
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        166..185
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   MOD_RES         54
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   209 AA;  22952 MW;  5D5B32BB2A69B23E CRC64;
     MYNKVLIIDD HPVLRFAVRV LMEKEGFEVI GETDNGIDGL KIAREKIPNL VVLDIGIPKL
     DGLEVIARLQ SLGLPLRVLV LTGQPPSLFA RRCLNSGAAG FVCKHENLHE VINAAKAVMA
     GYTYFPSTTL SEMRMGDNAK SDSTLISVLS NRELTVLQLL AQGMSNKDIA DSMFLSNKTV
     STYKTRLLQK LNATSLVELI DLAKRNNLA