BVGA_BORPE
ID BVGA_BORPE Reviewed; 209 AA.
AC P0A4H2; P16574;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Virulence factors putative positive transcription regulator BvgA;
GN Name=bvgA; OrderedLocusNames=BP1878;
OS Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=257313;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2549542; DOI=10.1073/pnas.86.17.6671;
RA Arico B., Miller J.F., Roy C., Stibitz S., Monack D.M., Falkow S.,
RA Gross R., Rappuoli R.;
RT "Sequences required for expression of Bordetella pertussis virulence
RT factors share homology with prokaryotic signal transduction proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:6671-6675(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX PubMed=12910271; DOI=10.1038/ng1227;
RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA Barrell B.G., Maskell D.J.;
RT "Comparative analysis of the genome sequences of Bordetella pertussis,
RT Bordetella parapertussis and Bordetella bronchiseptica.";
RL Nat. Genet. 35:32-40(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
RX PubMed=1697687; DOI=10.1073/pnas.87.17.6753;
RA Scarlato V., Prugnola A., Arico B., Rappuoli R.;
RT "Positive transcriptional feedback at the bvg locus controls expression of
RT virulence factors in Bordetella pertussis.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:6753-6757(1990).
RN [4]
RP CHARACTERIZATION.
RX PubMed=8302847; DOI=10.1073/pnas.91.3.1163;
RA Uhl M.A., Miller J.F.;
RT "Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS
RT signal transduction cascade.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:1163-1167(1994).
RN [5]
RP CHARACTERIZATION.
RX PubMed=9535079; DOI=10.1046/j.1365-2958.1998.00716.x;
RA Perraud A.-L., Kimmel B., Weiss V., Gross R.;
RT "Specificity of the BvgAS and EvgAS phosphorelay is mediated by the C-
RT terminal HPt domains of the sensor proteins.";
RL Mol. Microbiol. 27:875-887(1998).
RN [6]
RP CHARACTERIZATION, AND MASS SPECTROMETRY.
RX PubMed=10825546; DOI=10.1016/s0167-4838(00)00052-2;
RA Perraud A.-L., Rippe K., Bantscheff M., Glocker M., Lucassen M., Jung K.,
RA Sebald W., Weiss V., Gross R.;
RT "Dimerization of signalling modules of the EvgAS and BvgAS phosphorelay
RT systems.";
RL Biochim. Biophys. Acta 1478:341-354(2000).
CC -!- FUNCTION: Member of the two-component regulatory system BvgS/BvgA.
CC Activates the transcription of virulence genes.
CC -!- SUBUNIT: Homodimer.
CC -!- PTM: Phosphorylated by BvgS.
CC -!- MASS SPECTROMETRY: Mass=22949; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10825546};
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DR EMBL; M25401; AAA22969.1; -; Genomic_DNA.
DR EMBL; BX640416; CAE42161.1; -; Genomic_DNA.
DR PIR; B33729; VZBRGP.
DR RefSeq; NP_880570.1; NC_002929.2.
DR RefSeq; WP_010930609.1; NZ_CP039022.1.
DR AlphaFoldDB; P0A4H2; -.
DR SMR; P0A4H2; -.
DR STRING; 257313.BP1878; -.
DR GeneID; 56479102; -.
DR KEGG; bpe:BP1878; -.
DR PATRIC; fig|257313.5.peg.2017; -.
DR eggNOG; COG2197; Bacteria.
DR HOGENOM; CLU_000445_90_1_4; -.
DR OMA; PHVLTHM; -.
DR Proteomes; UP000002676; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Two-component regulatory system; Virulence.
FT CHAIN 1..209
FT /note="Virulence factors putative positive transcription
FT regulator BvgA"
FT /id="PRO_0000081034"
FT DOMAIN 4..119
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 142..207
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT DNA_BIND 166..185
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT MOD_RES 54
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 209 AA; 22952 MW; 5D5B32BB2A69B23E CRC64;
MYNKVLIIDD HPVLRFAVRV LMEKEGFEVI GETDNGIDGL KIAREKIPNL VVLDIGIPKL
DGLEVIARLQ SLGLPLRVLV LTGQPPSLFA RRCLNSGAAG FVCKHENLHE VINAAKAVMA
GYTYFPSTTL SEMRMGDNAK SDSTLISVLS NRELTVLQLL AQGMSNKDIA DSMFLSNKTV
STYKTRLLQK LNATSLVELI DLAKRNNLA
