ID   BWNIN_PONAB             Reviewed;          71 AA.
AC   Q5RDZ8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Protein BRAWNIN {ECO:0000250|UniProtKB:Q69YU5};
GN   Name=BRAWNIN {ECO:0000250|UniProtKB:Q69YU5};
GN   Synonyms=BR {ECO:0000250|UniProtKB:Q69YU5};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for mitochondrial respiratory chain complex III
CC       (CIII) assembly and stability. Also required for cytochrome c oxidase
CC       complex (complex IV) assembly. {ECO:0000250|UniProtKB:Q69YU5}.
CC   -!- SUBUNIT: Interacts with UQCRC1 (By similarity). Interacts with UQCRQ
CC       (By similarity). Interacts with SMIM4 (By similarity).
CC       {ECO:0000250|UniProtKB:Q69YU5, ECO:0000250|UniProtKB:Q8BTC1}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q69YU5}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q69YU5}.
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DR   EMBL; CR857742; CAH90009.1; -; mRNA.
DR   RefSeq; NP_001181969.1; NM_001195040.1.
DR   RefSeq; XP_009246443.1; XM_009248168.1.
DR   AlphaFoldDB; Q5RDZ8; -.
DR   SMR; Q5RDZ8; -.
DR   STRING; 9601.ENSPPYP00000005580; -.
DR   Ensembl; ENSPPYT00000005794; ENSPPYP00000005580; ENSPPYG00000004889.
DR   GeneID; 100171825; -.
DR   KEGG; pon:100171825; -.
DR   CTD; 113586447; -.
DR   eggNOG; ENOG502S9EP; Eukaryota.
DR   GeneTree; ENSGT00390000007685; -.
DR   HOGENOM; CLU_202878_0_0_1; -.
DR   InParanoid; Q5RDZ8; -.
DR   OMA; PRYLKMF; -.
DR   OrthoDB; 1635247at2759; -.
DR   TreeFam; TF333420; -.
DR   Proteomes; UP000001595; Chromosome 12.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; IEA:Ensembl.
DR   InterPro; IPR027858; BRAWNIN.
DR   PANTHER; PTHR28492; PTHR28492; 1.
DR   Pfam; PF14990; DUF4516; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..71
FT                   /note="Protein BRAWNIN"
FT                   /id="PRO_0000340275"
FT   TOPO_DOM        1..8
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:Q69YU5"
FT   TRANSMEM        9..25
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..71
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q69YU5"
FT   REGION          52..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   71 AA;  8003 MW;  C39866B5A718610B CRC64;
     MPAGVPMSTY LKMLAASLLA MCAGAEVVHR YYRPDLTIPE IPPKRGELKT ELLGLKERKH
     KPQISQQEEL K