ID   BXA2_SAMCY              Reviewed;         100 AA.
AC   P33719;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Bombyxin A-2 homolog;
DE   Contains:
DE     RecName: Full=Bombyxin A-2 homolog B chain;
DE   Contains:
DE     RecName: Full=Bombyxin A-2 homolog A chain;
DE   Flags: Precursor;
GN   Name=SBXA2;
OS   Samia cynthia (Ailanthus silkmoth) (Phalaena cynthia).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Saturniidae; Saturniinae; Attacini; Samia.
OX   NCBI_TaxID=7127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1601275; DOI=10.1016/0016-6480(92)90109-w;
RA   Kimura-Kawakami M., Iwami M., Kawakami A., Nagasawa H., Suzuki A.,
RA   Ishizaki H.;
RT   "Structure and expression of bombyxin-related peptide genes of the moth
RT   Samia cynthia ricini.";
RL   Gen. Comp. Endocrinol. 86:257-268(1992).
CC   -!- FUNCTION: Brain peptide responsible for activation of prothoracic
CC       glands to produce ecdysone in insects.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; D13924; BAA03021.1; -; Genomic_DNA.
DR   PIR; JQ0904; JQ0904.
DR   AlphaFoldDB; P33719; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR017097; Bombyxin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR040228; Insulin-relat-peptide_inver.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR13647; PTHR13647; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PIRSF; PIRSF037038; Bombyxin; 1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         19..44
FT                   /note="Bombyxin A-2 homolog B chain"
FT                   /id="PRO_0000016046"
FT   PROPEP          47..75
FT                   /note="C peptide like"
FT                   /id="PRO_0000016047"
FT   PEPTIDE         78..100
FT                   /note="Bombyxin A-2 homolog A chain"
FT                   /id="PRO_0000016048"
FT   DISULFID        26..85
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..98
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        84..89
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   100 AA;  11641 MW;  B188158E766F9875 CRC64;
     MRTQVLFLIV VLAVMASGDD TAHVYCGRRL ATMLLYVCDN QYQVKRPPYI SSENEGYGWK
     WLERQRARQL DEARGKRQGI VEECCNKPCT ENELLGYCYK