BXA6_BOMMO
ID BXA6_BOMMO Reviewed; 92 AA.
AC P26729; P07230;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Bombyxin A-6;
DE Short=BBX-A6;
DE AltName: Full=4K-prothoracicotropic hormone;
DE Short=4K-PTTH;
DE AltName: Full=Bombyxin-II;
DE Contains:
DE RecName: Full=Bombyxin A-6 B chain;
DE Contains:
DE RecName: Full=Bombyxin A-6 A chain;
DE Flags: Precursor;
GN Name=BBXA6;
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8683595; DOI=10.1006/jmbi.1996.0370;
RA Kondo H., Ino M., Suzuki A., Ishizaki H., Iwami M.;
RT "Multiple gene copies for bombyxin, an insulin-related peptide of the
RT silkmoth Bombyx mori: structural signs for gene rearrangement and
RT duplication responsible for generation of multiple molecular forms of
RT bombyxin.";
RL J. Mol. Biol. 259:926-937(1996).
RN [2]
RP PROTEIN SEQUENCE OF 20-47 AND 73-92, AND PYROGLUTAMATE FORMATION AT GLN-20.
RX PubMed=16593744; DOI=10.1073/pnas.83.16.5840;
RA Nagasawa H., Kataoka H., Isogai A., Tamura S., Suzuki A., Mizoguchi A.,
RA Fujiwara Y., Suzuki A., Takahashi S.Y., Ishizaki H.;
RT "Amino acid sequence of a prothoracicotropic hormone of the silkworm Bombyx
RT mori.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:5840-5843(1986).
RN [3]
RP STRUCTURE BY NMR.
RX PubMed=7473749; DOI=10.1006/jmbi.1995.0588;
RA Nagata K., Hatanaka H., Kohda D., Kataoka H., Nagasawa H., Isogai A.,
RA Ishizaki H., Suzuki A., Inagaki F.;
RT "Three-dimensional solution structure of bombyxin-II an insulin-like
RT peptide of the silkmoth Bombyx mori: structural comparison with insulin and
RT relaxin.";
RL J. Mol. Biol. 253:749-758(1995).
CC -!- FUNCTION: Brain peptide responsible for activation of prothoracic
CC glands to produce ecdysone in insects.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MISCELLANEOUS: Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH;
CC there are many forms of 4K-PTTH.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR EMBL; D00771; BAA00667.1; -; Genomic_DNA.
DR PIR; S69478; S69478.
DR PDB; 1BOM; NMR; -; B=21-47.
DR PDB; 1BON; NMR; -; B=21-47.
DR PDBsum; 1BOM; -.
DR PDBsum; 1BON; -.
DR AlphaFoldDB; P26729; -.
DR SMR; P26729; -.
DR eggNOG; ENOG502SESX; Eukaryota.
DR HOGENOM; CLU_125164_2_0_1; -.
DR InParanoid; P26729; -.
DR EvolutionaryTrace; P26729; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR017097; Bombyxin.
DR InterPro; IPR030680; Bombyxin_A.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR Pfam; PF00049; Insulin; 1.
DR PIRSF; PIRSF037038; Bombyxin; 1.
DR PIRSF; PIRSF500312; Bombyxin_A; 1.
DR PRINTS; PR02003; BOMBYXIN.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; SSF56994; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cleavage on pair of basic residues;
KW Direct protein sequencing; Disulfide bond; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000269|PubMed:16593744"
FT PEPTIDE 20..47
FT /note="Bombyxin A-6 B chain"
FT /id="PRO_0000015977"
FT PROPEP 50..70
FT /note="C peptide like"
FT /id="PRO_0000015978"
FT PEPTIDE 73..92
FT /note="Bombyxin A-6 A chain"
FT /id="PRO_0000015979"
FT MOD_RES 20
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:16593744"
FT DISULFID 29..79
FT /note="Interchain (between B and A chains)"
FT DISULFID 41..92
FT /note="Interchain (between B and A chains)"
FT DISULFID 78..83
FT TURN 32..35
FT /evidence="ECO:0007829|PDB:1BOM"
FT HELIX 36..38
FT /evidence="ECO:0007829|PDB:1BOM"
FT HELIX 40..43
FT /evidence="ECO:0007829|PDB:1BOM"
SQ SEQUENCE 92 AA; 10186 MW; 45A80860DD88C1EA CRC64;
MKILLAIALM LSTVMWVSTQ QPQAVHTYCG RHLARTLADL CWEAGVDKRS GAQFASYGSA
WLMPYSEGRG KRGIVDECCL RPCSVDVLLS YC
