BXA8_BOMMO
ID BXA8_BOMMO Reviewed; 89 AA.
AC P26731;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Bombyxin A-8;
DE Short=BBX-A8;
DE AltName: Full=4K-prothoracicotropic hormone;
DE Short=4K-PTTH;
DE Contains:
DE RecName: Full=Bombyxin A-8 B chain;
DE Contains:
DE RecName: Full=Bombyxin A-8 A chain;
DE Flags: Precursor;
GN Name=BBXA8;
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8683595; DOI=10.1006/jmbi.1996.0370;
RA Kondo H., Ino M., Suzuki A., Ishizaki H., Iwami M.;
RT "Multiple gene copies for bombyxin, an insulin-related peptide of the
RT silkmoth Bombyx mori: structural signs for gene rearrangement and
RT duplication responsible for generation of multiple molecular forms of
RT bombyxin.";
RL J. Mol. Biol. 259:926-937(1996).
CC -!- FUNCTION: Brain peptide responsible for activation of prothoracic
CC glands to produce ecdysone in insects.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MISCELLANEOUS: Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH;
CC there are many forms of 4K-PTTH.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D00774; BAA00670.1; -; Genomic_DNA.
DR EMBL; D00775; BAA00671.1; -; Genomic_DNA.
DR PIR; S69483; S69483.
DR PIR; S69484; S69484.
DR RefSeq; NP_001121630.1; NM_001128158.1.
DR AlphaFoldDB; P26731; -.
DR GeneID; 100169709; -.
DR KEGG; bmor:100169709; -.
DR CTD; 100169709; -.
DR HOGENOM; CLU_125164_2_0_1; -.
DR InParanoid; P26731; -.
DR OrthoDB; 1644517at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR017097; Bombyxin.
DR InterPro; IPR030680; Bombyxin_A.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR Pfam; PF00049; Insulin; 1.
DR PIRSF; PIRSF037038; Bombyxin; 1.
DR PIRSF; PIRSF500312; Bombyxin_A; 1.
DR PRINTS; PR02003; BOMBYXIN.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; SSF56994; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000250"
FT PEPTIDE 20..47
FT /note="Bombyxin A-8 B chain"
FT /id="PRO_0000015983"
FT PROPEP 50..68
FT /note="C peptide like"
FT /id="PRO_0000015984"
FT PEPTIDE 70..89
FT /note="Bombyxin A-8 A chain"
FT /id="PRO_0000015985"
FT MOD_RES 20
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT DISULFID 29..76
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 41..89
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 75..80
FT /evidence="ECO:0000250"
FT VARIANT 11
FT /note="L -> F"
SQ SEQUENCE 89 AA; 9951 MW; 791E769EC9099C34 CRC64;
MKLLLTIALM LSTVMWVSTQ QPQEVHTYCG RHLARTMADL CWEAGVDKRS DAQFASYGSA
WLMPYSAGRG IVDECCLRPC SVDVLLSYC
