BXB1_BOMMO
ID BXB1_BOMMO Reviewed; 89 AA.
AC P26733;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Bombyxin B-1;
DE Short=BBX-B1;
DE AltName: Full=4K-prothoracicotropic hormone;
DE Short=4K-PTTH;
DE Contains:
DE RecName: Full=Bombyxin B-1 B chain;
DE Contains:
DE RecName: Full=Bombyxin B-1 A chain;
DE Flags: Precursor;
GN Name=BBXB1;
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2674935; DOI=10.1073/pnas.86.18.6843;
RA Kawakami A., Iwami M., Nagasawa H., Suzuki A., Ishizaki H.;
RT "Structure and organization of four clustered genes that encode bombyxin,
RT an insulin-related brain secretory peptide of the silkmoth Bombyx mori.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:6843-6847(1989).
CC -!- FUNCTION: Brain peptide responsible for activation of prothoracic
CC glands to produce ecdysone in insects.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MISCELLANEOUS: Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH;
CC there are many forms of 4K-PTTH.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA27824.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M26068; AAA27824.1; ALT_INIT; Genomic_DNA.
DR PIR; A21182; A21182.
DR PIR; C41391; IPMTB1.
DR RefSeq; NP_001121791.1; NM_001128319.1.
DR AlphaFoldDB; P26733; -.
DR STRING; 7091.BGIBMGA014498-TA; -.
DR GeneID; 100169719; -.
DR KEGG; bmor:100169719; -.
DR CTD; 100169719; -.
DR eggNOG; ENOG502SESX; Eukaryota.
DR HOGENOM; CLU_125164_2_0_1; -.
DR InParanoid; P26733; -.
DR OrthoDB; 1638932at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR017097; Bombyxin.
DR InterPro; IPR027285; Bombyxin_B.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR Pfam; PF00049; Insulin; 2.
DR PIRSF; PIRSF037038; Bombyxin; 1.
DR PIRSF; PIRSF500313; Bombyxin_B; 1.
DR PRINTS; PR02003; BOMBYXIN.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; SSF56994; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PEPTIDE 20..45
FT /note="Bombyxin B-1 B chain"
FT /id="PRO_0000015989"
FT PROPEP 48..66
FT /note="C peptide like"
FT /id="PRO_0000015990"
FT PEPTIDE 69..89
FT /note="Bombyxin B-1 A chain"
FT /id="PRO_0000015991"
FT DISULFID 29..75
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 41..88
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 74..79
FT /evidence="ECO:0000250"
SQ SEQUENCE 89 AA; 9945 MW; 91941FF579D3DDF9 CRC64;
MKTSVMFMLV IVISLMCSGE AQEVARTYCG RHLADTLADL CFGVEKRGGA QYAPYFWTRQ
YLGSRGKRGV VDECCFRPCT LDVLLSYCG
