ID   TRMD_OLEA2              Reviewed;         425 AA.
AC   Q313J9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=tRNA (guanine-N(1)-)-methyltransferase;
DE            EC=2.1.1.228;
DE   AltName: Full=M1G-methyltransferase;
DE   AltName: Full=tRNA [GM37] methyltransferase;
GN   Name=trmD; OrderedLocusNames=Dde_1096;
OS   Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20)
OS   (Desulfovibrio alaskensis).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Oleidesulfovibrio.
OX   NCBI_TaxID=207559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1058 / DSM 17464 / G20;
RX   PubMed=21685289; DOI=10.1128/jb.05400-11;
RA   Hauser L.J., Land M.L., Brown S.D., Larimer F., Keller K.L.,
RA   Rapp-Giles B.J., Price M.N., Lin M., Bruce D.C., Detter J.C., Tapia R.,
RA   Han C.S., Goodwin L.A., Cheng J.F., Pitluck S., Copeland A., Lucas S.,
RA   Nolan M., Lapidus A.L., Palumbo A.V., Wall J.D.;
RT   "Complete genome sequence and updated annotation of Desulfovibrio
RT   alaskensis G20.";
RL   J. Bacteriol. 193:4268-4269(2011).
CC   -!- FUNCTION: Specifically methylates guanosine-37 in various tRNAs.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC         methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:36899, Rhea:RHEA-COMP:10145, Rhea:RHEA-COMP:10147,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.228;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the RNA methyltransferase TrmD family.
CC       {ECO:0000305}.
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DR   EMBL; CP000112; ABB37897.1; -; Genomic_DNA.
DR   RefSeq; WP_011367127.1; NC_007519.1.
DR   AlphaFoldDB; Q313J9; -.
DR   SMR; Q313J9; -.
DR   STRING; 207559.Dde_1096; -.
DR   EnsemblBacteria; ABB37897; ABB37897; Dde_1096.
DR   KEGG; dde:Dde_1096; -.
DR   eggNOG; COG0336; Bacteria.
DR   eggNOG; COG4752; Bacteria.
DR   HOGENOM; CLU_047363_2_1_7; -.
DR   OMA; NMDLHDI; -.
DR   OrthoDB; 525632at2; -.
DR   Proteomes; UP000002710; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0052906; F:tRNA (guanine(37)-N(1))-methyltransferase activity; IEA:UniProtKB-EC.
DR   CDD; cd18085; TM1570-like; 1.
DR   CDD; cd18080; TrmD-like; 1.
DR   Gene3D; 1.10.1270.20; -; 1.
DR   Gene3D; 3.40.1280.10; -; 2.
DR   HAMAP; MF_00605; TrmD; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR019230; RNA_MeTrfase_C_dom.
DR   InterPro; IPR002649; tRNA_m1G_MeTrfase_bac.
DR   InterPro; IPR023148; tRNA_m1G_MeTrfase_C_sf.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   InterPro; IPR016009; tRNA_MeTrfase_TRMD/TRM10.
DR   PANTHER; PTHR46417; PTHR46417; 1.
DR   Pfam; PF09936; Methyltrn_RNA_4; 1.
DR   Pfam; PF01746; tRNA_m1G_MT; 1.
DR   SUPFAM; SSF75217; SSF75217; 2.
DR   TIGRFAMs; TIGR00088; trmD; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing.
FT   CHAIN           1..425
FT                   /note="tRNA (guanine-N(1)-)-methyltransferase"
FT                   /id="PRO_0000257415"
FT   REGION          1..241
FT                   /note="tRNA (guanine-N(1)-)-methyltransferase"
FT   REGION          242..425
FT                   /note="Unknown"
FT   BINDING         109
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         129..134
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   425 AA;  46819 MW;  EEB154E7073A9753 CRC64;
     MRFNIVTLFP EYFDSPLACG LMGKARESGL VEVGFVNPRD HTTDRHRTVD DRPYGGGPGM
     VMMPGPLAAA LRSIPRPGRI LLMAPKGRPF TQELARELAT GDNLTIICGR YEGIDARLES
     VFPIEPVSMG DFVLNGGETA AMAVMEATGR LVPGYMGHEE SGEEESFSSG LLEYPHYTRP
     EIFEGHEVPE ILRSGDHGRI AAWRREQALK TTLLNRPEIL RDAQIDYNDL KILRKTDRER
     PGRNLYCALV HYPVVNKENK SVAVSLTNLD IHDIGRCSCT FGLGGYYITT PIEDQRRLLD
     GLLRHWTDGP GVSANPDRGT ALRLVRGVST VEEAIGDIEQ RTGQRPTVIA TSARGAGDTG
     FESVRRMLRE KPVLLLFGTA HGLAPDVLER CDGILRPIRS LDGYNHLSVR TAAAIIVDRV
     LGDAL