BXB8_BOMMO
ID BXB8_BOMMO Reviewed; 88 AA.
AC P26742;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Bombyxin B-8;
DE Short=BBX-B8;
DE AltName: Full=4K-prothoracicotropic hormone;
DE Short=4K-PTTH;
DE Contains:
DE RecName: Full=Bombyxin B-8 B chain;
DE Contains:
DE RecName: Full=Bombyxin B-8 A chain;
DE Flags: Precursor;
GN Name=BBXB8;
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8683595; DOI=10.1006/jmbi.1996.0370;
RA Kondo H., Ino M., Suzuki A., Ishizaki H., Iwami M.;
RT "Multiple gene copies for bombyxin, an insulin-related peptide of the
RT silkmoth Bombyx mori: structural signs for gene rearrangement and
RT duplication responsible for generation of multiple molecular forms of
RT bombyxin.";
RL J. Mol. Biol. 259:926-937(1996).
CC -!- FUNCTION: Brain peptide responsible for activation of prothoracic
CC glands to produce ecdysone in insects.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MISCELLANEOUS: Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH;
CC there are many forms of 4K-PTTH.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR EMBL; D00784; BAA00680.1; -; Genomic_DNA.
DR PIR; S69489; S69489.
DR RefSeq; NP_001121790.1; NM_001128318.1.
DR AlphaFoldDB; P26742; -.
DR STRING; 7091.BGIBMGA011971-TA; -.
DR EnsemblMetazoa; BGIBMGA011971-RA; BGIBMGA011971-TA; BGIBMGA011971.
DR GeneID; 100169718; -.
DR KEGG; bmor:100169718; -.
DR CTD; 100169718; -.
DR eggNOG; ENOG502SESX; Eukaryota.
DR HOGENOM; CLU_125164_2_0_1; -.
DR InParanoid; P26742; -.
DR OrthoDB; 1644517at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR017097; Bombyxin.
DR InterPro; IPR027285; Bombyxin_B.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR Pfam; PF00049; Insulin; 2.
DR PIRSF; PIRSF037038; Bombyxin; 1.
DR PIRSF; PIRSF500313; Bombyxin_B; 1.
DR PRINTS; PR02003; BOMBYXIN.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; SSF56994; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PEPTIDE 19..44
FT /note="Bombyxin B-8 B chain"
FT /id="PRO_0000016010"
FT PROPEP 47..65
FT /note="C peptide like"
FT /id="PRO_0000016011"
FT PEPTIDE 68..88
FT /note="Bombyxin B-8 A chain"
FT /id="PRO_0000016012"
FT DISULFID 28..74
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 40..87
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 73..78
FT /evidence="ECO:0000250"
SQ SEQUENCE 88 AA; 9706 MW; D27875F902DC8FAA CRC64;
MKTSVIFVLI VLNLMWSGEA QEVARTYCGS HLADTLADLC FGVVKRGGAQ YAPYFWQKAY
LGSRGKRGVV DECCFRPCTL DVLASYCG
