ID   BXC1_BOMMO              Reviewed;          91 AA.
AC   P15410;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 2.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Bombyxin C-1;
DE            Short=BBX-C1;
DE   AltName: Full=4K-prothoracicotropic hormone;
DE            Short=4K-PTTH;
DE   Contains:
DE     RecName: Full=Bombyxin C-1 B chain;
DE   Contains:
DE     RecName: Full=Bombyxin C-1 A chain;
DE   Flags: Precursor;
GN   Name=BBXC1;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Iwami M., Adachi T., Kondo H., Kawakami A., Suzuki Y., Nagasawa H.,
RA   Suzuki A., Ishizaki H.;
RT   "A novel family C of the genes that encode bombyxin, an insulin-related
RT   brain secretory peptide of the silkmoth Bombyx mori: isolation and
RT   characterization of gene C-1.";
RL   Insect Biochem. 20:295-303(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8683595; DOI=10.1006/jmbi.1996.0370;
RA   Kondo H., Ino M., Suzuki A., Ishizaki H., Iwami M.;
RT   "Multiple gene copies for bombyxin, an insulin-related peptide of the
RT   silkmoth Bombyx mori: structural signs for gene rearrangement and
RT   duplication responsible for generation of multiple molecular forms of
RT   bombyxin.";
RL   J. Mol. Biol. 259:926-937(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 49-91.
RX   PubMed=2708384; DOI=10.1016/s0021-9258(18)83288-4;
RA   Adachi T., Takiya S., Suzuki Y., Iwami M., Kawakami A., Takahashi S.Y.,
RA   Ishizaki H., Nagasawa H., Suzuki A.;
RT   "cDNA structure and expression of bombyxin, an insulin-like brain secretory
RT   peptide of the silkmoth Bombyx mori.";
RL   J. Biol. Chem. 264:7681-7685(1989).
CC   -!- FUNCTION: Brain peptide responsible for activation of prothoracic
CC       glands to produce ecdysone in insects.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH;
CC       there are many forms of 4K-PTTH.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; D00790; BAA00686.1; -; Genomic_DNA.
DR   EMBL; D00791; BAA00687.1; -; Genomic_DNA.
DR   EMBL; J04728; AAA27823.1; -; mRNA.
DR   PIR; A60296; A60296.
DR   RefSeq; NP_001119736.1; NM_001126264.1.
DR   AlphaFoldDB; P15410; -.
DR   EnsemblMetazoa; BGIBMGA011968-RA; BGIBMGA011968-TA; BGIBMGA011968.
DR   GeneID; 100147698; -.
DR   KEGG; bmor:100147698; -.
DR   CTD; 100147698; -.
DR   eggNOG; ENOG502SESX; Eukaryota.
DR   HOGENOM; CLU_125164_2_0_1; -.
DR   InParanoid; P15410; -.
DR   OMA; DECCYRP; -.
DR   OrthoDB; 1644517at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR017097; Bombyxin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   Pfam; PF00049; Insulin; 1.
DR   PIRSF; PIRSF037038; Bombyxin; 1.
DR   PRINTS; PR02003; BOMBYXIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         20..44
FT                   /note="Bombyxin C-1 B chain"
FT                   /id="PRO_0000016025"
FT   PROPEP          47..67
FT                   /note="C peptide like"
FT                   /id="PRO_0000016026"
FT   PEPTIDE         70..91
FT                   /note="Bombyxin C-1 A chain"
FT                   /id="PRO_0000016027"
FT   MOD_RES         20
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..76
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..89
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        75..80
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   91 AA;  10137 MW;  8DD8CF9251FB97B8 CRC64;
     MKLVMLLVVV SAMLVLGGAQ TASQFYCGDF LARTMSSLCW SDMQKRSGSQ YAGYGWPWLP
     PFSSSRGKRG IVDECCYRPC TIDVLMSYCD N