ID   BXF1_BOMMO              Reviewed;          95 AA.
AC   P91896; P91897;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Bombyxin F-1;
DE            Short=BBX-F1;
DE   Contains:
DE     RecName: Full=Bombyxin F-1 B chain;
DE   Contains:
DE     RecName: Full=Bombyxin F-1 A chain;
DE   Flags: Precursor;
GN   Name=BBXF1;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Kinshu, and Showa;
RX   PubMed=9401466; DOI=10.2108/zsj.14.615;
RA   Yoshida I., Tsuzuki S., Abdel Salam S., Ino M., Korayem A.M., Sakurai S.,
RA   Iwami M.;
RT   "Bombyxin F1 gene: structure and expression of a new bombyxin family gene
RT   that forms a pair with bombyxin B10 gene.";
RL   Zool. Sci. 14:615-622(1997).
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB001049; BAA19223.1; -; Genomic_DNA.
DR   EMBL; AB001050; BAA19224.1; -; Genomic_DNA.
DR   RefSeq; NP_001119734.1; NM_001126262.1.
DR   AlphaFoldDB; P91896; -.
DR   STRING; 7091.BGIBMGA011930-TA; -.
DR   GeneID; 100146110; -.
DR   KEGG; bmor:100146110; -.
DR   CTD; 100146110; -.
DR   HOGENOM; CLU_125164_2_0_1; -.
DR   InParanoid; P91896; -.
DR   OrthoDB; 1644517at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR017097; Bombyxin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   Pfam; PF00049; Insulin; 1.
DR   PIRSF; PIRSF037038; Bombyxin; 1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         20..50
FT                   /note="Bombyxin F-1 B chain"
FT                   /id="PRO_0000016037"
FT   PROPEP          53..71
FT                   /note="C peptide like"
FT                   /id="PRO_0000016038"
FT   PEPTIDE         76..95
FT                   /note="Bombyxin F-1 A chain"
FT                   /id="PRO_0000016039"
FT   DISULFID        29..82
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..95
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        81..86
FT                   /evidence="ECO:0000250"
FT   VARIANT         71
FT                   /note="T -> A (in strain: Showa)"
SQ   SEQUENCE   95 AA;  10567 MW;  5EF960C1322707CC CRC64;
     MKLVVIVLLV ISVSILVSAQ ELGGSRRYCG RHLAQTMAVL CWGIDEMSAE KRNSDMVYED
     SGMPELLPAD TRKKRGIIDE CCLQACTRDV LLSYC