ID   BXG1_BOMMO              Reviewed;          90 AA.
AC   O61271;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Bombyxin G-1;
DE            Short=BBX-G1;
DE   Contains:
DE     RecName: Full=Bombyxin G-1 B chain;
DE   Contains:
DE     RecName: Full=Bombyxin G-1 A chain;
DE   Flags: Precursor;
GN   Name=BBXG1;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Kinshu, and Showa;
RX   PubMed=9732555; DOI=10.1007/s004270050197;
RA   Yoshida I., Moto K., Sakurai S., Iwami M.;
RT   "A novel member of the bombyxin gene family: structure and expression of
RT   bombyxin G1 gene, an insulin-related peptide gene of the silkmoth Bombyx
RT   mori.";
RL   Dev. Genes Evol. 208:407-410(1998).
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; AB010380; BAA25679.1; -; Genomic_DNA.
DR   EMBL; AB010381; BAA31431.1; -; Genomic_DNA.
DR   RefSeq; NP_001121634.1; NM_001128162.1.
DR   AlphaFoldDB; O61271; -.
DR   EnsemblMetazoa; BGIBMGA011972-RA; BGIBMGA011972-TA; BGIBMGA011972.
DR   GeneID; 100169726; -.
DR   KEGG; bmor:100169726; -.
DR   CTD; 100169726; -.
DR   eggNOG; ENOG502SESX; Eukaryota.
DR   HOGENOM; CLU_125164_2_0_1; -.
DR   InParanoid; O61271; -.
DR   OMA; CITIYGS; -.
DR   OrthoDB; 1644517at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR017097; Bombyxin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   Pfam; PF00049; Insulin; 1.
DR   PIRSF; PIRSF037038; Bombyxin; 1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         20..46
FT                   /note="Bombyxin G-1 B chain"
FT                   /id="PRO_0000016040"
FT   PROPEP          49..67
FT                   /note="C peptide like"
FT                   /id="PRO_0000016041"
FT   PEPTIDE         70..90
FT                   /note="Bombyxin G-1 A chain"
FT                   /id="PRO_0000016042"
FT   DISULFID        28..77
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..90
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        76..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   90 AA;  10311 MW;  CBD0D61862B84FF4 CRC64;
     MKLIIFVVFC ITIYGSTSGQ QEVARRYCGR HLAVTMADLC FGVQFDKRNT QYEGYHWPLL
     AYSEERIKRQ GIADECCLVP CTTNVLSSYC