BXI1_SCHPO
ID BXI1_SCHPO Reviewed; 266 AA.
AC O74888;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Bax inhibitor 1;
DE AltName: Full=BH3 domain-containing protein bxi1;
GN Name=bxi1; Synonyms=ybh3; ORFNames=SPCC576.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Links the unfolded protein response and programmed cell death
CC and mediates mitochondrial-dependent apoptosis. Induces cell death and
CC disruption of the mitochondrial transmembrane potential (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Mitochondrion membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi
CC apparatus membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane
CC protein {ECO:0000269|PubMed:16823372}. Vacuole membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the BI1 family. LFG subfamily. {ECO:0000305}.
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DR EMBL; CU329672; CAA21183.1; -; Genomic_DNA.
DR PIR; T41414; T41414.
DR RefSeq; NP_588431.1; NM_001023422.2.
DR AlphaFoldDB; O74888; -.
DR SMR; O74888; -.
DR STRING; 4896.SPCC576.04.1; -.
DR MaxQB; O74888; -.
DR PaxDb; O74888; -.
DR EnsemblFungi; SPCC576.04.1; SPCC576.04.1:pep; SPCC576.04.
DR GeneID; 2539556; -.
DR KEGG; spo:SPCC576.04; -.
DR PomBase; SPCC576.04; bxi1.
DR VEuPathDB; FungiDB:SPCC576.04; -.
DR eggNOG; KOG2322; Eukaryota.
DR HOGENOM; CLU_058671_0_0_1; -.
DR InParanoid; O74888; -.
DR OMA; SHNAYAE; -.
DR PhylomeDB; O74888; -.
DR PRO; PR:O74888; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IC:PomBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISO:PomBase.
DR GO; GO:0019722; P:calcium-mediated signaling; ISO:PomBase.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; ISO:PomBase.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR PANTHER; PTHR23291; PTHR23291; 1.
DR Pfam; PF01027; Bax1-I; 1.
PE 3: Inferred from homology;
KW Apoptosis; Endoplasmic reticulum; Golgi apparatus; Membrane; Mitochondrion;
KW Reference proteome; Transmembrane; Transmembrane helix; Vacuole.
FT CHAIN 1..266
FT /note="Bax inhibitor 1"
FT /id="PRO_0000316210"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 266 AA; 30402 MW; 73F27234EFE66D47 CRC64;
MPANYQSVPQ DDPSVPNLAQ APPAYSEYNE SATENPAVDQ FKNTTPVAEC AKSIRMAFLR
KVYAILTAQL FVTSLFGGIF YLHPAFSFWV QMHPWFLILN FFISLVVLFG LIMKPYSYPR
NYIFLFLFTA LEGLTLGTAI TFFSARIILE AVFITLGVFV ALTAFTFQSK WDFSRLGGFL
YVSLWSLILT PLIFFFVPST PFIDMAFAGF GTLVFCGYIL FDTYNILHRY SPEEFIMSSL
MLYLDFINLF IRILQILGML QNNDNN
