ID   BXRA_AGRCO              Reviewed;         103 AA.
AC   O09209; O09208;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Bombyxin-related peptide A;
DE   AltName: Full=ABRP;
DE   Contains:
DE     RecName: Full=Bombyxin-related peptide A chain B;
DE   Contains:
DE     RecName: Full=Bombyxin-related peptide A chain A;
DE   Flags: Precursor;
OS   Agrius convolvuli (Convolvulus hawk-moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Acherontiini; Agrius.
OX   NCBI_TaxID=55055;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Brain {ECO:0000269|PubMed:8673077};
RX   PubMed=8673077; DOI=10.1016/0965-1748(95)00057-7;
RA   Iwami M., Furuya I., Kataoka H.;
RT   "Bombyxin-related peptides: cDNA structure and expression in the brain of
RT   the hornworm Agrius convolvuli.";
RL   Insect Biochem. Mol. Biol. 26:25-32(1996).
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|RuleBase:RU000406,
CC       ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Located in 4 pairs of medial neurosecretory cells
CC       in the brain. {ECO:0000269|PubMed:8673077}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; D63147; BAA20091.1; -; mRNA.
DR   EMBL; D63146; BAA20090.1; -; mRNA.
DR   AlphaFoldDB; O09209; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0018445; F:prothoracicotrophic hormone activity; NAS:UniProtKB.
DR   InterPro; IPR017097; Bombyxin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   Pfam; PF00049; Insulin; 1.
DR   PIRSF; PIRSF037038; Bombyxin; 1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         20..54
FT                   /note="Bombyxin-related peptide A chain B"
FT                   /id="PRO_0000015956"
FT   PROPEP          57..80
FT                   /note="C peptide like"
FT                   /id="PRO_0000015957"
FT   PEPTIDE         83..103
FT                   /note="Bombyxin-related peptide A chain A"
FT                   /id="PRO_0000015958"
FT   DISULFID        33..90
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..103
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..94
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   103 AA;  11221 MW;  E1372C7EFC66A85C CRC64;
     MKLLVVLCCF FAVYSLAAAQ GGQEEFQIKV RICGRHLART LADLCPNVEY EDVMKRSGAR
     SPALYGTVGW PWARPGAARG KRAGVADDCC VNSCTMDVLL SYC