ID   BYE1_DEBHA              Reviewed;         682 AA.
AC   Q6BNY5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Transcription factor BYE1;
GN   Name=BYE1; OrderedLocusNames=DEHA2E17996g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Negative regulator of transcription elongation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00651}.
CC   -!- SIMILARITY: Belongs to the BYE1 family. {ECO:0000305}.
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DR   EMBL; CR382137; CAG88347.2; -; Genomic_DNA.
DR   RefSeq; XP_460085.2; XM_460085.1.
DR   AlphaFoldDB; Q6BNY5; -.
DR   SMR; Q6BNY5; -.
DR   STRING; 4959.XP_460085.2; -.
DR   EnsemblFungi; CAG88347; CAG88347; DEHA2E17996g.
DR   GeneID; 2902502; -.
DR   KEGG; dha:DEHA2E17996g; -.
DR   VEuPathDB; FungiDB:DEHA2E17996g; -.
DR   eggNOG; KOG1634; Eukaryota.
DR   HOGENOM; CLU_370099_0_0_1; -.
DR   InParanoid; Q6BNY5; -.
DR   OMA; RTHKGDI; -.
DR   OrthoDB; 1022991at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.472.30; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR012921; SPOC_C.
DR   InterPro; IPR003618; TFIIS_cen_dom.
DR   InterPro; IPR036575; TFIIS_cen_dom_sf.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF07744; SPOC; 1.
DR   Pfam; PF07500; TFIIS_M; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00510; TFS2M; 1.
DR   SUPFAM; SSF46942; SSF46942; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..682
FT                   /note="Transcription factor BYE1"
FT                   /id="PRO_0000324849"
FT   DOMAIN          155..275
FT                   /note="TFIIS central"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00651"
FT   ZN_FING         74..132
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   REGION          1..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          576..599
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..373
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        577..599
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   682 AA;  77734 MW;  00DF9030CAEB17CE CRC64;
     MSTRRSSRAN KGQHSKREID FYVDEEDLPS ERKRSLSNSS QDNKRPHLDQ DEDDGDYKEN
     GEEKKDDDIE EEGEVRCTPC GTTSENYDED SDQGGTMIEC ESCKTWQHAK CMGYRTSKTI
     PKHYRCNVCS GLNGDKLEKT NVDSSAISEK LKDKTRASVA KAFVNVFKRN IPESYKSPEG
     MDNEKLSSKW AIELEREIFI WCPKKDKKYT DKSRSLMVLI KKPNVMTRLI DGELSFTKLV
     NSPPEEIDSE LKEYAERVRS ESIRRSVLTV DANQGQRIRR THKGEEIVED ASNQQEDVDI
     SIMTRNIDHR RFEDEEPARG IIVNDNSKPA YNNYMEDEDD DEVGEEEAEE KQKQGSDKEG
     STSDDKEGLP SSDIDDVPDL DDDELDFIIK GKKETKEETR KPSSIKLPPI FSSKIWSGRI
     TFPDFASFGA TGEFYTCSNY KNPTNPQEVK LHNRYVNISK EILSKDHYEV EGRLDRTRAD
     AYLDKIITTR DLILVEIKCT ENRSGYDKLY RYLLERNKVG VLSGRPAFVK DAYLLGIDGN
     DFNLPEYLKA LHKMVGKVGL FALYIVKKDY VPTGPSILKK STPNPTDYNS HSSNASSKEK
     TPLLDSILYK LGGNGTKKEN IQIQTPQYNP PVAQNGLPTS LTTDQLSYLS GLVQQNPQVQ
     QNPQALIQLL QQQKNTDYSP YH