BYE1_SCHPO
ID BYE1_SCHPO Reviewed; 721 AA.
AC Q9Y7V2; Q1MXG6; Q9UTW8; Q9UU07;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Transcription factor bye1;
GN Name=bye1; ORFNames=SPCC645.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 53-199, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
CC -!- FUNCTION: Negative regulator of transcription elongation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00651,
CC ECO:0000269|PubMed:10759889}.
CC -!- SIMILARITY: Belongs to the BYE1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329672; CAB39909.1; -; Genomic_DNA.
DR EMBL; AB027885; BAA87189.1; -; Genomic_DNA.
DR EMBL; AB027953; BAA87257.1; -; Genomic_DNA.
DR PIR; T41530; T41530.
DR RefSeq; NP_588122.1; NM_001023112.2.
DR AlphaFoldDB; Q9Y7V2; -.
DR SMR; Q9Y7V2; -.
DR BioGRID; 275285; 23.
DR STRING; 4896.SPCC645.13.1; -.
DR iPTMnet; Q9Y7V2; -.
DR MaxQB; Q9Y7V2; -.
DR PaxDb; Q9Y7V2; -.
DR PRIDE; Q9Y7V2; -.
DR EnsemblFungi; SPCC645.13.1; SPCC645.13.1:pep; SPCC645.13.
DR PomBase; SPCC645.13; bye1.
DR VEuPathDB; FungiDB:SPCC645.13; -.
DR eggNOG; KOG1634; Eukaryota.
DR HOGENOM; CLU_024990_1_0_1; -.
DR InParanoid; Q9Y7V2; -.
DR OMA; ASNYLCG; -.
DR PhylomeDB; Q9Y7V2; -.
DR Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-SPO-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-SPO-6782135; Dual incision in TC-NER.
DR Reactome; R-SPO-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR Reactome; R-SPO-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-SPO-75955; RNA Polymerase II Transcription Elongation.
DR PRO; PR:Q9Y7V2; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001139; F:RNA polymerase II complex recruiting activity; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0003711; F:transcription elongation regulator activity; ISS:PomBase.
DR GO; GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; ISS:PomBase.
DR GO; GO:0070647; P:protein modification by small protein conjugation or removal; IC:PomBase.
DR GO; GO:0031440; P:regulation of mRNA 3'-end processing; IBA:GO_Central.
DR GO; GO:0031564; P:transcription antitermination; IBA:GO_Central.
DR GO; GO:0006362; P:transcription elongation from RNA polymerase I promoter; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.472.30; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR012921; SPOC_C.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF07744; SPOC; 1.
DR Pfam; PF07500; TFIIS_M; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00510; TFS2M; 1.
DR SUPFAM; SSF46942; SSF46942; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..721
FT /note="Transcription factor bye1"
FT /id="PRO_0000116549"
FT DOMAIN 217..347
FT /note="TFIIS central"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00651"
FT ZN_FING 20..69
FT /note="PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT REGION 93..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 97..100
FT /note="GNEK -> RERE (in Ref. 2; BAA87257)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 721 AA; 79739 MW; 32EA032A41BE0B08 CRC64;
MVRKSTRRTA KASEKPPETV VRCVCKSQED IGDTWVQCDG CDCWQHASCV GLADKDIPES
YYCEVCHSRS DVSSQVQNSP NKDEEHQTAD LLASNEGNEK NNEENNVVSS DSKEAITKES
GAELESSEPA STNSNVGMTT RSGRQSPRTP IGSTTPKSSH SPPSTRKRRG SVGTTATHTK
RSKNAPKTSP KDASNETADQ EKELSLHTSI DEIQNPVRKS VAKAWVSVFE KIIEKAKLEG
VQGLEDLNST SLALQLEHIM FMVLSYTTDH SLTPNNKYRE KFRALRFNLV DDKNPAFRAR
VLKNEISFND LVNLSSEEMA NPDLKNLAEE IRQQSTENTV IKQHLIAPRD RLLDEDKLTQ
QDELGIAEND DAMFPKPPGE LVAPISIAEE EPTIDSKSPT LPEHNPLSED DTSNGDKAAK
RKGSFNDTKP IVNVPSIVEI DDPTILDIVE EEPLARNDSF SSPYSPAEDM AEESEFFGMK
EKIWTGKVKM ATVSEFHANA LNLFGDVSAS HLFEILSATA LIEGRISVSS VLQYFHALRK
TPSKEIIAVL FVPTEQNSQG FDILYDYFVK RNRYGVLHSK SNSVKDAYII PMPSGNSVPE
LLDLLPKVDL PKDRNFQYFM GLFVLNKSSS RHESVERATP ITTSTNGIPS TYQSASGTPT
NPVHSYPSLE SIINALTPSD MLLIKDVVEN NPQIRANPSL AINPQFMQNA ISAAQKKASK
Q
