BYE1_YARLI
ID BYE1_YARLI Reviewed; 822 AA.
AC Q6C0K9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Transcription factor BYE1;
GN Name=BYE1; OrderedLocusNames=YALI0F23815g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Negative regulator of transcription elongation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00651}.
CC -!- SIMILARITY: Belongs to the BYE1 family. {ECO:0000305}.
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DR EMBL; CR382132; CAG78614.1; -; Genomic_DNA.
DR RefSeq; XP_505803.1; XM_505803.1.
DR AlphaFoldDB; Q6C0K9; -.
DR SMR; Q6C0K9; -.
DR STRING; 4952.CAG78614; -.
DR EnsemblFungi; CAG78614; CAG78614; YALI0_F23815g.
DR GeneID; 2908747; -.
DR KEGG; yli:YALI0F23815g; -.
DR VEuPathDB; FungiDB:YALI0_F23815g; -.
DR HOGENOM; CLU_344246_0_0_1; -.
DR InParanoid; Q6C0K9; -.
DR OMA; ASNYLCG; -.
DR Proteomes; UP000001300; Chromosome F.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0001139; F:RNA polymerase II complex recruiting activity; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0031440; P:regulation of mRNA 3'-end processing; IBA:GO_Central.
DR GO; GO:0031564; P:transcription antitermination; IBA:GO_Central.
DR GO; GO:0006362; P:transcription elongation from RNA polymerase I promoter; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.472.30; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR012921; SPOC_C.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF07744; SPOC; 1.
DR Pfam; PF07500; TFIIS_M; 1.
DR SMART; SM00510; TFS2M; 1.
DR SUPFAM; SSF46942; SSF46942; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 3: Inferred from homology;
KW Metal-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..822
FT /note="Transcription factor BYE1"
FT /id="PRO_0000324851"
FT DOMAIN 198..323
FT /note="TFIIS central"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00651"
FT ZN_FING 78..132
FT /note="PHD-type"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 822 AA; 89591 MW; 21A5FD637CD8A680 CRC64;
MEVDGAEPAR RRSTRATRGR HSKYEEAVEE PGKVKSDKKD PKTSDKNPKT TKLKTPTKAK
TTTRSKARKK SKNDEEGVVR CPCGATEDDP SDGKIMIECE DCLEWQHSQC VLQTNDLEQV
PDHYVCNECT EKKTQEKETT EAQEESEDKG KGEEEKDSND KDEKYDSTYV PNNETAEKEP
VARVSKSTHK RVGHIDDITE KVRKSAASAL KGIFVSVPTS KYSPGAGVSP EQFCETLALT
IEQELYDAYG TVEPEIGSNY RDKFRTLSFN LRDSKNETLR IRVMTGQVTP QTLVAMSSEE
MMNPELQKLA EEVRAEAIRD TVLVVDEAPR LRRTHKGEEI VGEYEEYIDN VDQALKMERQ
RDGDGKEAAE SRNQIERAVR DIEGANGEAD SKTSNSPKES SNSPIVPKWK RDIDLAQGES
DHEHDHDHNS DHEDKVNGIL GDVSREAREA ETDDWTTISE APFVWTGTVP MAGLDKTSCA
AFSLGSSSVH FNPNVSWGSV FYASKPLTIE GRLDKSKADP YLSKVLGAGT RDVAAFCLLP
SDSSESDREA YYKLYEYFHS RSKYGVIHNR STLVKDAYLI PLAPDDAPPY TLGSLVKPSV
ELSSLKRSRP LLVALYIVGK LSPKRGAAVS VESHVASSEK HPPKRQSMRD RVKQNAGNAG
NASRRASDAR KSTPPVTATP VTPAAPTLVA PVNAPVGPAP VVPPYAGFQG GVYGAPVGIQ
RVPGAPMGVP GVPIAPAGMP GVPVAPLGMH GAPAHHMAQS GTPIAPAAHP RKPTGAPPPD
LDALKTLLND PNLRNAPAAP AQNDLLQNPA LLMSIIDQAK KR
