ID   TRMHL_STAAM             Reviewed;         248 AA.
AC   Q99W72;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Putative TrmH family tRNA/rRNA methyltransferase;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=SAV0531;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB56693.1; -; Genomic_DNA.
DR   RefSeq; WP_000390332.1; NC_002758.2.
DR   AlphaFoldDB; Q99W72; -.
DR   SMR; Q99W72; -.
DR   World-2DPAGE; 0002:Q99W72; -.
DR   PaxDb; Q99W72; -.
DR   EnsemblBacteria; BAB56693; BAB56693; SAV0531.
DR   KEGG; sav:SAV0531; -.
DR   HOGENOM; CLU_021322_0_1_9; -.
DR   OMA; QVPPYEY; -.
DR   PhylomeDB; Q99W72; -.
DR   BioCyc; SAUR158878:SAV_RS02985-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR46429; PTHR46429; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
DR   TIGRFAMs; TIGR00186; rRNA_methyl_3; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Transferase.
FT   CHAIN           1..248
FT                   /note="Putative TrmH family tRNA/rRNA methyltransferase"
FT                   /id="PRO_0000224828"
FT   BINDING         196
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         216
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         225
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   248 AA;  27181 MW;  8DFB9C9777F95543 CRC64;
     MEDTVIVGRH AVREAIITGH PINKILIQEG IKKQQINEIL KNAKDQKIIV QTVPKSKLDF
     LANAPHQGVA ALIAPYEYAD FDQFLKQQKE KEGLSTVLIL DGLEDPHNLG SILRTADATG
     VDGVIIPKRR SVTLTQTVAK ASTGAIEHVP VIRVTNLAKT IDELKDNGFW VAGTEANNAT
     DYRNLEADMS LAIVIGSEGQ GMSRLVSDKC DFYIKIPMVG HVNSLNASVA ASLMMYEVFR
     KRHDVGEI