ID   TRMHL_STAAW             Reviewed;         248 AA.
AC   Q7A1Q9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Putative TrmH family tRNA/rRNA methyltransferase;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MW0487;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
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DR   EMBL; BA000033; BAB94352.1; -; Genomic_DNA.
DR   RefSeq; WP_000390332.1; NC_003923.1.
DR   AlphaFoldDB; Q7A1Q9; -.
DR   SMR; Q7A1Q9; -.
DR   EnsemblBacteria; BAB94352; BAB94352; BAB94352.
DR   KEGG; sam:MW0487; -.
DR   HOGENOM; CLU_021322_0_1_9; -.
DR   OMA; QVPPYEY; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR46429; PTHR46429; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
DR   TIGRFAMs; TIGR00186; rRNA_methyl_3; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Transferase.
FT   CHAIN           1..248
FT                   /note="Putative TrmH family tRNA/rRNA methyltransferase"
FT                   /id="PRO_0000224829"
FT   BINDING         196
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         216
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         225
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   248 AA;  27181 MW;  8DFB9C9777F95543 CRC64;
     MEDTVIVGRH AVREAIITGH PINKILIQEG IKKQQINEIL KNAKDQKIIV QTVPKSKLDF
     LANAPHQGVA ALIAPYEYAD FDQFLKQQKE KEGLSTVLIL DGLEDPHNLG SILRTADATG
     VDGVIIPKRR SVTLTQTVAK ASTGAIEHVP VIRVTNLAKT IDELKDNGFW VAGTEANNAT
     DYRNLEADMS LAIVIGSEGQ GMSRLVSDKC DFYIKIPMVG HVNSLNASVA ASLMMYEVFR
     KRHDVGEI