ID   TRMHL_STAES             Reviewed;         249 AA.
AC   Q8CTT9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Putative TrmH family tRNA/rRNA methyltransferase;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=SE_0294;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO03891.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE015929; AAO03891.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_763849.1; NC_004461.1.
DR   RefSeq; WP_002494715.1; NC_004461.1.
DR   AlphaFoldDB; Q8CTT9; -.
DR   SMR; Q8CTT9; -.
DR   STRING; 176280.SE_0294; -.
DR   EnsemblBacteria; AAO03891; AAO03891; SE_0294.
DR   KEGG; sep:SE_0294; -.
DR   PATRIC; fig|176280.10.peg.270; -.
DR   eggNOG; COG0566; Bacteria.
DR   HOGENOM; CLU_021322_0_1_9; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR46429; PTHR46429; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
DR   TIGRFAMs; TIGR00186; rRNA_methyl_3; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Transferase.
FT   CHAIN           1..249
FT                   /note="Putative TrmH family tRNA/rRNA methyltransferase"
FT                   /id="PRO_0000224831"
FT   BINDING         196
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         216
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         225
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   249 AA;  27321 MW;  A1337734D7189663 CRC64;
     MEDIVIVGRH AVKEAIISGH AINKILIQDG IKKQQINDIL KNAKSQKLIV QTVPKSKLDF
     LANAPHQGVA ALVAPYEYAN FDEFLQKQKK KARYSTVIIL DGLEDPHNLG SILRTADASG
     VDAVIIPKRR SVALTQTVAK ASTGAIQHVP VIRVTNLSKT IDELKDNGFW IAGTEANNAT
     DYRDLQADMS LGIVIGSEGQ GMSRLVSDKC DFHIKIPMVG HVNSLNASVA ASLMMYEVYR
     KRHQLEEKS