BYN_DROME
ID BYN_DROME Reviewed; 697 AA.
AC P55965; Q9VTQ7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=T-related protein;
DE Short=Trp;
DE AltName: Full=Protein brachyenteron;
GN Name=byn; Synonyms=trg; ORFNames=CG7260;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=7958884; DOI=10.1101/gad.8.18.2137;
RA Kispert A., Herrmann B.G., Leptin M., Reuter R.;
RT "Homologs of the mouse Brachyury gene are involved in the specification of
RT posterior terminal structures in Drosophila, Tribolium, and Locusta.";
RL Genes Dev. 8:2137-2150(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Required for the specification of the hindgut and anal pads.
CC {ECO:0000269|PubMed:7958884}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
CC -!- DEVELOPMENTAL STAGE: First expressed at the beginning of nuclear cycle
CC 14 in the posterior terminal region. As cellularization proceeds,
CC expression becomes confined to a ring area encompassing the primordium
CC of the hindgut and anal pads. Expression is maintained in this region
CC until the end of embryogenesis. {ECO:0000269|PubMed:7958884}.
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DR EMBL; S74163; AAB32396.2; -; mRNA.
DR EMBL; AE014296; AAF49989.2; -; Genomic_DNA.
DR PIR; A55160; A55160.
DR RefSeq; NP_524031.2; NM_079307.2.
DR AlphaFoldDB; P55965; -.
DR SMR; P55965; -.
DR BioGRID; 64710; 5.
DR IntAct; P55965; 1.
DR STRING; 7227.FBpp0304380; -.
DR PaxDb; P55965; -.
DR EnsemblMetazoa; FBtr0332070; FBpp0304380; FBgn0011723.
DR GeneID; 39349; -.
DR KEGG; dme:Dmel_CG7260; -.
DR CTD; 39349; -.
DR FlyBase; FBgn0011723; byn.
DR VEuPathDB; VectorBase:FBgn0011723; -.
DR eggNOG; KOG3585; Eukaryota.
DR InParanoid; P55965; -.
DR PhylomeDB; P55965; -.
DR BioGRID-ORCS; 39349; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 39349; -.
DR PRO; PR:P55965; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0011723; Expressed in adult hindgut (Drosophila) and 11 other tissues.
DR ExpressionAtlas; P55965; baseline and differential.
DR Genevisible; P55965; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003677; F:DNA binding; ISS:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001709; P:cell fate determination; TAS:FlyBase.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0003007; P:heart morphogenesis; IBA:GO_Central.
DR GO; GO:0007442; P:hindgut morphogenesis; IMP:FlyBase.
DR GO; GO:0007443; P:Malpighian tubule morphogenesis; IMP:FlyBase.
DR GO; GO:0001707; P:mesoderm formation; IBA:GO_Central.
DR GO; GO:0007509; P:mesoderm migration involved in gastrulation; TAS:FlyBase.
DR GO; GO:0007494; P:midgut development; IMP:FlyBase.
DR GO; GO:0007280; P:pole cell migration; TAS:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00182; TBOX; 1.
DR Gene3D; 2.60.40.820; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR002070; TF_Brachyury.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; PTHR11267; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00938; BRACHYURY.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..697
FT /note="T-related protein"
FT /id="PRO_0000184467"
FT DNA_BIND 96..264
FT /note="T-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 321
FT /note="E -> G (in Ref. 1; AAB32396)"
FT /evidence="ECO:0000305"
FT CONFLICT 426
FT /note="S -> P (in Ref. 1; AAB32396)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 697 AA; 72117 MW; C30FD62E20F936D5 CRC64;
MTTSHILSAV DPTTGLSGNV SGGGGGGGAG GGAGSGSPQH VTHNGHGHGH GLGGVAAVSG
GGASVSGNGG HRVVGGAGSP NELDRNLRIS LDDRELWLRF QNLTNEMIVT KNGRRMFPVV
KISASGLDPA AMYTVLLEFV QIDSHRWKYV NGEWVPGGKA EVPPSNPIYV HPESPNFGAH
WMKEPISFAK VKLTNKTNGN GQIMLNSLHK YEPRVHLVRV GSEQRHVVTY PFPETQFIAV
TAYQNEEVTS LKIKYNPFAK AFLDAKERPD TLYPHDTHYG WLIPPPTHYT AAAAAVAAPP
PLSIAQSHGL VASCPSVSSA ESVGPSSGGS CDRYGRSLSS RSVAPTRTTP YSRPRVVSGS
GSNGSAGNAS STSPQPPSAP QTPTSLHSTS TGSVSTSVSS SSGGGIGSAP STGCFSSSYA
QSGFMSVDAS PTASVFSYPS SWQSNGNYWN ATSVPGPMPM NVCSGRNISS HNSPSPTNGS
PSYTTSSPSY TIHHLTPHSH QYNMAQTDIY GTGVGVGGGA GTTGSPQAAY GAAAHQVYHP
TPTSPTHQLY TNAVLNAPSA LSYSASGWHN GSGAEYGLYQ NAAAAYYQPE YIPLEIGYAT
HPLEPVDVSK TLDDPQAAMY KPSDEQGSVI TLECASSSLK SSHDIKIESS SLEHAGERGT
VGGGAAVVSV PTAVVNGAPA VAADTWTPLT PPQSTLQ
