TRML4_HUMAN
ID TRML4_HUMAN Reviewed; 200 AA.
AC Q6UXN2; B7ZL92;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Trem-like transcript 4 protein;
DE Short=TLT-4;
DE AltName: Full=Triggering receptor expressed on myeloid cells-like protein 4;
DE Flags: Precursor;
GN Name=TREML4; Synonyms=TLT4; ORFNames=UNQ9425/PRO34675;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=24975946; DOI=10.1016/j.ajhg.2014.06.003;
RG NISC Comparative Sequencing Program;
RG CHARGE Consortium;
RA Sen S.K., Boelte K.C., Barb J.J., Joehanes R., Zhao X., Cheng Q., Adams L.,
RA Teer J.K., Accame D.S., Chowdhury S., Singh L.N., Kavousi M., Peyser P.A.,
RA Quigley L., Priel D.L., Lau K., Kuhns D.B., Yoshimura T., Johnson A.D.,
RA Hwang S.J., Chen M.Y., Arai A.E., Green E.D., Mullikin J.C., Kolodgie F.D.,
RA O'Donnell C.J., Virmani R., Munson P.J., McVicar D.W., Biesecker L.G.;
RT "Integrative DNA, RNA, and protein evidence connects TREML4 to coronary
RT artery calcification.";
RL Am. J. Hum. Genet. 95:66-76(2014).
RN [4]
RP FUNCTION.
RX PubMed=25848864; DOI=10.1038/ni.3143;
RA Ramirez-Ortiz Z.G., Prasad A., Griffith J.W., Pendergraft W.F. III,
RA Cowley G.S., Root D.E., Tai M., Luster A.D., El Khoury J., Hacohen N.,
RA Means T.K.;
RT "The receptor TREML4 amplifies TLR7-mediated signaling during antiviral
RT responses and autoimmunity.";
RL Nat. Immunol. 16:495-504(2015).
CC -!- FUNCTION: Positively regulates Toll-like receptor TLR7 signaling in
CC macrophages. {ECO:0000269|PubMed:25848864}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24975946}.
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DR EMBL; AY358271; AAQ88638.1; -; mRNA.
DR EMBL; BC101780; AAI01781.1; -; mRNA.
DR EMBL; BC105101; AAI05102.1; -; mRNA.
DR EMBL; BC143652; AAI43653.1; -; mRNA.
DR CCDS; CCDS34446.1; -.
DR RefSeq; NP_937796.1; NM_198153.2.
DR AlphaFoldDB; Q6UXN2; -.
DR SMR; Q6UXN2; -.
DR STRING; 9606.ENSP00000342570; -.
DR GlyGen; Q6UXN2; 1 site.
DR PhosphoSitePlus; Q6UXN2; -.
DR BioMuta; TREML4; -.
DR DMDM; 74762374; -.
DR MassIVE; Q6UXN2; -.
DR PaxDb; Q6UXN2; -.
DR PeptideAtlas; Q6UXN2; -.
DR PRIDE; Q6UXN2; -.
DR Antibodypedia; 70761; 41 antibodies from 14 providers.
DR DNASU; 285852; -.
DR Ensembl; ENST00000341495.7; ENSP00000342570.2; ENSG00000188056.12.
DR Ensembl; ENST00000448827.6; ENSP00000418078.1; ENSG00000188056.12.
DR GeneID; 285852; -.
DR KEGG; hsa:285852; -.
DR MANE-Select; ENST00000341495.7; ENSP00000342570.2; NM_198153.3; NP_937796.1.
DR UCSC; uc003oqc.3; human.
DR CTD; 285852; -.
DR DisGeNET; 285852; -.
DR GeneCards; TREML4; -.
DR HGNC; HGNC:30807; TREML4.
DR HPA; ENSG00000188056; Tissue enhanced (choroid).
DR MIM; 614664; gene.
DR neXtProt; NX_Q6UXN2; -.
DR OpenTargets; ENSG00000188056; -.
DR PharmGKB; PA134993202; -.
DR VEuPathDB; HostDB:ENSG00000188056; -.
DR eggNOG; ENOG502TG0M; Eukaryota.
DR GeneTree; ENSGT00940000153835; -.
DR HOGENOM; CLU_051023_2_1_1; -.
DR InParanoid; Q6UXN2; -.
DR OMA; PYQSKTW; -.
DR OrthoDB; 1340491at2759; -.
DR PhylomeDB; Q6UXN2; -.
DR TreeFam; TF337556; -.
DR PathwayCommons; Q6UXN2; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR BioGRID-ORCS; 285852; 8 hits in 1057 CRISPR screens.
DR GenomeRNAi; 285852; -.
DR Pharos; Q6UXN2; Tbio.
DR PRO; PR:Q6UXN2; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q6UXN2; protein.
DR Bgee; ENSG00000188056; Expressed in buccal mucosa cell and 58 other tissues.
DR ExpressionAtlas; Q6UXN2; baseline and differential.
DR Genevisible; Q6UXN2; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0034157; P:positive regulation of toll-like receptor 7 signaling pathway; IMP:UniProtKB.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain;
KW Innate immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..200
FT /note="Trem-like transcript 4 protein"
FT /id="PRO_0000307276"
FT DOMAIN 26..126
FT /note="Ig-like V-type"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 40..109
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 73
FT /note="W -> R (in dbSNP:rs9369265)"
FT /id="VAR_035390"
FT VARIANT 146
FT /note="T -> K (in dbSNP:rs9471515)"
FT /id="VAR_035391"
FT VARIANT 168
FT /note="T -> I (in dbSNP:rs7769759)"
FT /id="VAR_035392"
SQ SEQUENCE 200 AA; 21924 MW; EF9AC4326847DB32 CRC64;
MAWGGVHTCC FHLCCCCSWP QGAVPEELHK HPGQTLLLQC QYSPKRGPYQ PKSWCQQTSP
SRCTLLVTSS KPWTAVQKSH YTIWDKPNAG FFNITMIQLT QNDSGFYWCG IYNASENIIT
VLRNISLVVS PAPTTSPMWT LPWLPTSTVL ITSPEGTSGH PSINGSETRK SRAPACLGSG
GPRFLVLVLC GLLLAKGLML
