ID   BYST_BOVIN              Reviewed;         435 AA.
AC   Q5E9N0; B0JYL5;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Bystin;
GN   Name=BYSL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for processing of 20S pre-rRNA precursor and
CC       biogenesis of 40S ribosomal subunits. {ECO:0000250|UniProtKB:Q13895}.
CC   -!- SUBUNIT: Binds trophinin, tastin and cytokeratins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q13895}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:Q13895}. Note=Associated with
CC       40S ribosomal subunits. {ECO:0000250|UniProtKB:Q13895}.
CC   -!- SIMILARITY: Belongs to the bystin family. {ECO:0000305}.
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DR   EMBL; BT020890; AAX08907.1; -; mRNA.
DR   EMBL; BC151370; AAI51371.1; -; mRNA.
DR   RefSeq; NP_001014924.1; NM_001014924.1.
DR   AlphaFoldDB; Q5E9N0; -.
DR   SMR; Q5E9N0; -.
DR   STRING; 9913.ENSBTAP00000013326; -.
DR   PaxDb; Q5E9N0; -.
DR   PRIDE; Q5E9N0; -.
DR   Ensembl; ENSBTAT00000013326; ENSBTAP00000013326; ENSBTAG00000010101.
DR   GeneID; 514128; -.
DR   KEGG; bta:514128; -.
DR   CTD; 705; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010101; -.
DR   VGNC; VGNC:26611; BYSL.
DR   eggNOG; KOG3871; Eukaryota.
DR   GeneTree; ENSGT00390000007241; -.
DR   HOGENOM; CLU_029727_0_0_1; -.
DR   InParanoid; Q5E9N0; -.
DR   OMA; AGGQEKH; -.
DR   OrthoDB; 1193442at2759; -.
DR   TreeFam; TF312968; -.
DR   Proteomes; UP000009136; Chromosome 23.
DR   Bgee; ENSBTAG00000010101; Expressed in digestive system secreted substance and 106 other tissues.
DR   GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR   GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Ensembl.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR   GO; GO:0001829; P:trophectodermal cell differentiation; IEA:Ensembl.
DR   InterPro; IPR007955; Bystin.
DR   PANTHER; PTHR12821; PTHR12821; 1.
DR   Pfam; PF05291; Bystin; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Methylation; Nucleus; Phosphoprotein; Reference proteome;
KW   Ribosome biogenesis.
FT   CHAIN           1..435
FT                   /note="Bystin"
FT                   /id="PRO_0000237613"
FT   REGION          1..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         40
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13895"
FT   MOD_RES         98
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13895"
FT   MOD_RES         154
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13895"
FT   MOD_RES         165
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13895"
FT   MOD_RES         412
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13895"
SQ   SEQUENCE   435 AA;  49379 MW;  632E01249131B903 CRC64;
     MPKFKAARGA GVQEKHAPLA EQILAGDAVR AGTREKRRGR GTGDEEEEYV GPRLTRRILQ
     QARQQQEELE AEHGSGDRPA VPRERTTRLG PGVPQDGSDD EEWPTLEQAA ARAGPGYQAE
     VVVDPEDERA IEMFMNQNPP ARRTLADIIM EKLTEKQTEV ETVMSEVSGF PVPQLDPRVL
     EVYRGVREVL SKYRSGKLPK AFKIIPALSN WEQILYITEP EAWTAAAMYQ ATRIFASNLK
     ERMAQRFYNL VLLPRVRDDI AEYKRLNFHL YMALKKALFK PGAWFKGILI PLCESGTCTL
     REAIIVGSII TKCSIPVLHS SAAMLKIAEM EYSGANSIFL RLLLDKKYAL PYRVLDALVF
     HFLGFRTEKR ELPVLWHQCL LTLVQRYKAD LATEQKEALL ELLRLQPHPQ LSPEIRRELQ
     SAVPRDVEDV PVTME