ID   BYST_DICDI              Reviewed;         475 AA.
AC   Q54IS0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Bystin;
GN   Name=bysl; ORFNames=DDB_G0288565;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for processing of 20S pre-rRNA precursor and
CC       biogenesis of 40S ribosomal subunits. {ECO:0000250|UniProtKB:Q13895}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q13895}.
CC   -!- SIMILARITY: Belongs to the bystin family. {ECO:0000305}.
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DR   EMBL; AAFI02000117; EAL63142.1; -; Genomic_DNA.
DR   RefSeq; XP_636644.1; XM_631552.1.
DR   AlphaFoldDB; Q54IS0; -.
DR   SMR; Q54IS0; -.
DR   STRING; 44689.DDB0266395; -.
DR   PaxDb; Q54IS0; -.
DR   EnsemblProtists; EAL63142; EAL63142; DDB_G0288565.
DR   GeneID; 8626690; -.
DR   KEGG; ddi:DDB_G0288565; -.
DR   dictyBase; DDB_G0288565; bysl.
DR   eggNOG; KOG3871; Eukaryota.
DR   HOGENOM; CLU_029727_0_1_1; -.
DR   InParanoid; Q54IS0; -.
DR   OMA; AGGQEKH; -.
DR   PhylomeDB; Q54IS0; -.
DR   Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q54IS0; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR007955; Bystin.
DR   PANTHER; PTHR12821; PTHR12821; 1.
DR   Pfam; PF05291; Bystin; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..475
FT                   /note="Bystin"
FT                   /id="PRO_0000327726"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  54775 MW;  54C2E6B1B3805948 CRC64;
     MGKDVKKVHK LRHDPLSKQI EESESAYQKP HKRVGKLRKK KAEMENDTGI DETESVIPSA
     LSKKILDQIR EQAIEVEVED RKKEKQEKLL TFEQERIQSK LLSFNDFIDD DDDDEDADQD
     DNKRRSNGND FDENDGFEQF SDTESQFGVG GEVEIDEEDE RVLSMFMGGG GGDGQEQQFQ
     TRFTLGDIIE SKLKEHESRQ VSSENAINPK VIDVYTKVGK LLETYTSGKI PRAFRILPNF
     TNWEDLLYLT RPDKWTPHSI RVATKLFCMS TNSKITQRFL SIVVLPRVRD NIAEYKKLNY
     HLYMALKKSL YRPAAFYKAI LLPLAESGDC TLLEAKIIGS VVCKVSIPVL HSSVALMKLS
     QLTRYNGATS MFIRMLCDKK YALPYRVIDG LVDHFVMFDE EVRELPVLWH RALLSFVQRY
     KTDITKDQKE KLKIILRKHN HHIITAEIRR ELFFSNSRGG VAPSNFTDDT SSMME