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BYST_HUMAN
ID   BYST_HUMAN              Reviewed;         437 AA.
AC   Q13895; Q6P5W4; Q86W44; Q96IP8;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 3.
DT   03-AUG-2022, entry version 180.
DE   RecName: Full=Bystin {ECO:0000305};
GN   Name=BYSL {ECO:0000312|HGNC:HGNC:1157};
GN   Synonyms=ENP1 {ECO:0000303|PubMed:26711351};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung, Ovary, and Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 131-437.
RC   TISSUE=Choriocarcinoma;
RX   PubMed=9560222; DOI=10.1073/pnas.95.9.5027;
RA   Suzuki N., Zara J., Sato T., Ong E., Bakhiet N., Oshima R.G., Watson K.L.,
RA   Fukuda M.N.;
RT   "A cytoplasmic protein, bystin, interacts with trophinin, tastin, and
RT   cytokeratin and may be involved in trophinin-mediated cell adhesion between
RT   trophoblast and endometrial epithelial cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:5027-5032(1998).
RN   [3]
RP   SEQUENCE REVISION.
RA   Fukuda M.N.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT   networks.";
RL   Cell 127:635-648(2006).
RN   [5]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=17381424; DOI=10.1042/bj20061597;
RA   Miyoshi M., Okajima T., Matsuda T., Fukuda M.N., Nadano D.;
RT   "Bystin in human cancer cells: intracellular localization and function in
RT   ribosome biogenesis.";
RL   Biochem. J. 404:373-381(2007).
RN   [6]
RP   FUNCTION.
RX   PubMed=17360433; DOI=10.1073/pnas.0611516104;
RA   Sugihara K., Sugiyama D., Byrne J., Wolf D.P., Lowitz K.P., Kobayashi Y.,
RA   Kabir-Salmani M., Nadano D., Aoki D., Nozawa S., Nakayama J., Mustelin T.,
RA   Ruoslahti E., Yamaguchi N., Fukuda M.N.;
RT   "Trophoblast cell activation by trophinin ligation is implicated in human
RT   embryo implantation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:3799-3804(2007).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA   Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA   Greff Z., Keri G., Stemmann O., Mann M.;
RT   "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT   kinome across the cell cycle.";
RL   Mol. Cell 31:438-448(2008).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=18318008; DOI=10.1002/pmic.200700884;
RA   Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,
RA   Zou H., Gu J.;
RT   "Large-scale phosphoproteome analysis of human liver tissue by enrichment
RT   and fractionation of phosphopeptides with strong anion exchange
RT   chromatography.";
RL   Proteomics 8:1346-1361(2008).
RN   [10]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [11]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-167, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [12]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [13]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [14]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [15]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55; SER-98; THR-156 AND
RP   SER-414, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [16]
RP   METHYLATION [LARGE SCALE ANALYSIS] AT ARG-40, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Colon carcinoma;
RX   PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA   Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA   Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA   Bedford M.T., Comb M.J.;
RT   "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT   methylation.";
RL   Mol. Cell. Proteomics 13:372-387(2014).
RN   [17]
RP   SUBCELLULAR LOCATION.
RX   PubMed=26711351; DOI=10.1016/j.celrep.2015.11.061;
RA   Badertscher L., Wild T., Montellese C., Alexander L.T., Bammert L.,
RA   Sarazova M., Stebler M., Csucs G., Mayer T.U., Zamboni N., Zemp I.,
RA   Horvath P., Kutay U.;
RT   "Genome-wide RNAi Screening Identifies Protein Modules Required for 40S
RT   Subunit Synthesis in Human Cells.";
RL   Cell Rep. 13:2879-2891(2015).
CC   -!- FUNCTION: Required for processing of 20S pre-rRNA precursor and
CC       biogenesis of 40S ribosomal subunits. May be required for trophinin-
CC       dependent regulation of cell adhesion during implantation of human
CC       embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}.
CC   -!- SUBUNIT: Binds trophinin, tastin and cytokeratins.
CC   -!- INTERACTION:
CC       Q13895; Q13155: AIMP2; NbExp=5; IntAct=EBI-358049, EBI-745226;
CC       Q13895; Q9Y2J4: AMOTL2; NbExp=3; IntAct=EBI-358049, EBI-746752;
CC       Q13895; P06576: ATP5F1B; NbExp=3; IntAct=EBI-358049, EBI-356231;
CC       Q13895; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-358049, EBI-4400025;
CC       Q13895; Q8N7W2-2: BEND7; NbExp=8; IntAct=EBI-358049, EBI-10181188;
CC       Q13895; Q12934-2: BFSP1; NbExp=3; IntAct=EBI-358049, EBI-12123320;
CC       Q13895; O14503: BHLHE40; NbExp=3; IntAct=EBI-358049, EBI-711810;
CC       Q13895; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-358049, EBI-946029;
CC       Q13895; P20807-4: CAPN3; NbExp=3; IntAct=EBI-358049, EBI-11532021;
CC       Q13895; O14958: CASQ2; NbExp=3; IntAct=EBI-358049, EBI-6859557;
CC       Q13895; Q5BKX8: CAVIN4; NbExp=3; IntAct=EBI-358049, EBI-12836558;
CC       Q13895; Q68D86: CCDC102B; NbExp=6; IntAct=EBI-358049, EBI-10171570;
CC       Q13895; Q96JN2-2: CCDC136; NbExp=5; IntAct=EBI-358049, EBI-10171416;
CC       Q13895; Q9UJX2: CDC23; NbExp=5; IntAct=EBI-358049, EBI-396137;
CC       Q13895; Q96GN5: CDCA7L; NbExp=5; IntAct=EBI-358049, EBI-5278764;
CC       Q13895; Q9C0F1: CEP44; NbExp=5; IntAct=EBI-358049, EBI-744115;
CC       Q13895; Q8IYX8-2: CEP57L1; NbExp=5; IntAct=EBI-358049, EBI-10181988;
CC       Q13895; Q8NHQ1: CEP70; NbExp=8; IntAct=EBI-358049, EBI-739624;
CC       Q13895; P38432: COIL; NbExp=11; IntAct=EBI-358049, EBI-945751;
CC       Q13895; Q92841: DDX17; NbExp=6; IntAct=EBI-358049, EBI-746012;
CC       Q13895; Q8NF50-2: DOCK8; NbExp=5; IntAct=EBI-358049, EBI-10174653;
CC       Q13895; Q56P03: EAPP; NbExp=3; IntAct=EBI-358049, EBI-748732;
CC       Q13895; P50402: EMD; NbExp=6; IntAct=EBI-358049, EBI-489887;
CC       Q13895; Q12929: EPS8; NbExp=3; IntAct=EBI-358049, EBI-375576;
CC       Q13895; Q15303: ERBB4; NbExp=3; IntAct=EBI-358049, EBI-80371;
CC       Q13895; Q86W67: FAM228A; NbExp=3; IntAct=EBI-358049, EBI-12958227;
CC       Q13895; Q8IZU0: FAM9B; NbExp=5; IntAct=EBI-358049, EBI-10175124;
CC       Q13895; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-358049, EBI-11977403;
CC       Q13895; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-358049, EBI-10172181;
CC       Q13895; P51114-2: FXR1; NbExp=3; IntAct=EBI-358049, EBI-11022345;
CC       Q13895; P51116: FXR2; NbExp=8; IntAct=EBI-358049, EBI-740459;
CC       Q13895; O95995: GAS8; NbExp=3; IntAct=EBI-358049, EBI-1052570;
CC       Q13895; Q96IK5: GMCL1; NbExp=5; IntAct=EBI-358049, EBI-2548508;
CC       Q13895; Q08379: GOLGA2; NbExp=8; IntAct=EBI-358049, EBI-618309;
CC       Q13895; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-358049, EBI-5916454;
CC       Q13895; Q4V328: GRIPAP1; NbExp=3; IntAct=EBI-358049, EBI-717919;
CC       Q13895; Q6NT76: HMBOX1; NbExp=8; IntAct=EBI-358049, EBI-2549423;
CC       Q13895; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-358049, EBI-740641;
CC       Q13895; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-358049, EBI-10961706;
CC       Q13895; O75031: HSF2BP; NbExp=3; IntAct=EBI-358049, EBI-7116203;
CC       Q13895; Q13422: IKZF1; NbExp=5; IntAct=EBI-358049, EBI-745305;
CC       Q13895; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-358049, EBI-11522367;
CC       Q13895; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-358049, EBI-747204;
CC       Q13895; O75564-2: JRK; NbExp=3; IntAct=EBI-358049, EBI-17181882;
CC       Q13895; Q9BW62: KATNAL1; NbExp=3; IntAct=EBI-358049, EBI-743591;
CC       Q13895; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-358049, EBI-3437878;
CC       Q13895; Q9BVG8-5: KIFC3; NbExp=5; IntAct=EBI-358049, EBI-14069005;
CC       Q13895; O95198: KLHL2; NbExp=3; IntAct=EBI-358049, EBI-746999;
CC       Q13895; Q8WZ60: KLHL6; NbExp=3; IntAct=EBI-358049, EBI-6426464;
CC       Q13895; Q15323: KRT31; NbExp=3; IntAct=EBI-358049, EBI-948001;
CC       Q13895; Q6A162: KRT40; NbExp=8; IntAct=EBI-358049, EBI-10171697;
CC       Q13895; P60370: KRTAP10-5; NbExp=5; IntAct=EBI-358049, EBI-10172150;
CC       Q13895; P60409: KRTAP10-7; NbExp=5; IntAct=EBI-358049, EBI-10172290;
CC       Q13895; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-358049, EBI-10172511;
CC       Q13895; Q96JM7: L3MBTL3; NbExp=5; IntAct=EBI-358049, EBI-2686809;
CC       Q13895; Q96JM7-2: L3MBTL3; NbExp=3; IntAct=EBI-358049, EBI-11985629;
CC       Q13895; O95751: LDOC1; NbExp=4; IntAct=EBI-358049, EBI-740738;
CC       Q13895; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-358049, EBI-12039345;
CC       Q13895; P25800: LMO1; NbExp=3; IntAct=EBI-358049, EBI-8639312;
CC       Q13895; P25791-3: LMO2; NbExp=3; IntAct=EBI-358049, EBI-11959475;
CC       Q13895; Q17RB8: LONRF1; NbExp=8; IntAct=EBI-358049, EBI-2341787;
CC       Q13895; Q96GA3: LTV1; NbExp=11; IntAct=EBI-358049, EBI-2558389;
CC       Q13895; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-358049, EBI-1216080;
CC       Q13895; Q9BRK4: LZTS2; NbExp=6; IntAct=EBI-358049, EBI-741037;
CC       Q13895; Q8IYB1: MB21D2; NbExp=3; IntAct=EBI-358049, EBI-11323212;
CC       Q13895; D6RGH6: MCIDAS; NbExp=3; IntAct=EBI-358049, EBI-3954372;
CC       Q13895; Q9HAF1: MEAF6; NbExp=3; IntAct=EBI-358049, EBI-399266;
CC       Q13895; P50221: MEOX1; NbExp=3; IntAct=EBI-358049, EBI-2864512;
CC       Q13895; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-358049, EBI-16439278;
CC       Q13895; O15344: MID1; NbExp=4; IntAct=EBI-358049, EBI-2340316;
CC       Q13895; Q9UJV3-2: MID2; NbExp=8; IntAct=EBI-358049, EBI-10172526;
CC       Q13895; Q8TD10: MIPOL1; NbExp=8; IntAct=EBI-358049, EBI-2548751;
CC       Q13895; Q9UHC7: MKRN1; NbExp=3; IntAct=EBI-358049, EBI-373524;
CC       Q13895; O00566: MPHOSPH10; NbExp=3; IntAct=EBI-358049, EBI-5235884;
CC       Q13895; Q96HT8: MRFAP1L1; NbExp=13; IntAct=EBI-358049, EBI-748896;
CC       Q13895; Q8NCY6: MSANTD4; NbExp=3; IntAct=EBI-358049, EBI-7850168;
CC       Q13895; Q5JR59: MTUS2; NbExp=5; IntAct=EBI-358049, EBI-742948;
CC       Q13895; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-358049, EBI-11522433;
CC       Q13895; Q7Z6G3-2: NECAB2; NbExp=6; IntAct=EBI-358049, EBI-10172876;
CC       Q13895; P35240-4: NF2; NbExp=3; IntAct=EBI-358049, EBI-1014514;
CC       Q13895; Q7RTU3: OLIG3; NbExp=5; IntAct=EBI-358049, EBI-10225049;
CC       Q13895; Q9H4L5: OSBPL3; NbExp=3; IntAct=EBI-358049, EBI-1051317;
CC       Q13895; Q5VU43: PDE4DIP; NbExp=5; IntAct=EBI-358049, EBI-1105124;
CC       Q13895; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-358049, EBI-9640281;
CC       Q13895; Q8IXK0: PHC2; NbExp=6; IntAct=EBI-358049, EBI-713786;
CC       Q13895; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-358049, EBI-79165;
CC       Q13895; Q9NWS0: PIH1D1; NbExp=3; IntAct=EBI-358049, EBI-357318;
CC       Q13895; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-358049, EBI-302345;
CC       Q13895; Q9UL42: PNMA2; NbExp=7; IntAct=EBI-358049, EBI-302355;
CC       Q13895; Q96MT3: PRICKLE1; NbExp=3; IntAct=EBI-358049, EBI-2348662;
CC       Q13895; P62333: PSMC6; NbExp=3; IntAct=EBI-358049, EBI-357669;
CC       Q13895; Q9H0H5: RACGAP1; NbExp=3; IntAct=EBI-358049, EBI-717233;
CC       Q13895; P63244: RACK1; NbExp=3; IntAct=EBI-358049, EBI-296739;
CC       Q13895; Q53GL6: RALY; NbExp=3; IntAct=EBI-358049, EBI-9512693;
CC       Q13895; Q86SE5: RALYL; NbExp=3; IntAct=EBI-358049, EBI-741520;
CC       Q13895; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-358049, EBI-1210429;
CC       Q13895; Q8TA86: RP9; NbExp=3; IntAct=EBI-358049, EBI-630339;
CC       Q13895; Q92622: RUBCN; NbExp=3; IntAct=EBI-358049, EBI-2952709;
CC       Q13895; Q16637: SMN2; NbExp=8; IntAct=EBI-358049, EBI-395421;
CC       Q13895; Q13573: SNW1; NbExp=3; IntAct=EBI-358049, EBI-632715;
CC       Q13895; Q9Y2D8: SSX2IP; NbExp=5; IntAct=EBI-358049, EBI-2212028;
CC       Q13895; O75558: STX11; NbExp=8; IntAct=EBI-358049, EBI-714135;
CC       Q13895; Q969V4: TEKT1; NbExp=6; IntAct=EBI-358049, EBI-10180409;
CC       Q13895; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-358049, EBI-1105213;
CC       Q13895; Q9NVV9: THAP1; NbExp=8; IntAct=EBI-358049, EBI-741515;
CC       Q13895; Q08117: TLE5; NbExp=5; IntAct=EBI-358049, EBI-717810;
CC       Q13895; Q08117-2: TLE5; NbExp=5; IntAct=EBI-358049, EBI-11741437;
CC       Q13895; Q15025: TNIP1; NbExp=8; IntAct=EBI-358049, EBI-357849;
CC       Q13895; Q12933: TRAF2; NbExp=3; IntAct=EBI-358049, EBI-355744;
CC       Q13895; Q9BUZ4: TRAF4; NbExp=9; IntAct=EBI-358049, EBI-3650647;
CC       Q13895; Q14142: TRIM14; NbExp=3; IntAct=EBI-358049, EBI-2820256;
CC       Q13895; P14373: TRIM27; NbExp=6; IntAct=EBI-358049, EBI-719493;
CC       Q13895; O94972: TRIM37; NbExp=9; IntAct=EBI-358049, EBI-741602;
CC       Q13895; O00635: TRIM38; NbExp=3; IntAct=EBI-358049, EBI-2130415;
CC       Q13895; Q8WV44: TRIM41; NbExp=5; IntAct=EBI-358049, EBI-725997;
CC       Q13895; Q9BYV2: TRIM54; NbExp=7; IntAct=EBI-358049, EBI-2130429;
CC       Q13895; Q9BYV6-2: TRIM55; NbExp=3; IntAct=EBI-358049, EBI-11522718;
CC       Q13895; Q15654: TRIP6; NbExp=6; IntAct=EBI-358049, EBI-742327;
CC       Q13895; Q12816: TRO; NbExp=4; IntAct=EBI-358049, EBI-950001;
CC       Q13895; Q12815: TROAP; NbExp=9; IntAct=EBI-358049, EBI-2349743;
CC       Q13895; A4D1L5: UBE2H; NbExp=3; IntAct=EBI-358049, EBI-10230777;
CC       Q13895; Q495M9: USH1G; NbExp=3; IntAct=EBI-358049, EBI-8601749;
CC       Q13895; P08670: VIM; NbExp=3; IntAct=EBI-358049, EBI-353844;
CC       Q13895; Q9H9H4: VPS37B; NbExp=8; IntAct=EBI-358049, EBI-4400866;
CC       Q13895; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-358049, EBI-2799833;
CC       Q13895; Q9UPY6-2: WASF3; NbExp=3; IntAct=EBI-358049, EBI-12026286;
CC       Q13895; Q15007: WTAP; NbExp=3; IntAct=EBI-358049, EBI-751647;
CC       Q13895; O43829: ZBTB14; NbExp=8; IntAct=EBI-358049, EBI-10176632;
CC       Q13895; Q96BR9: ZBTB8A; NbExp=8; IntAct=EBI-358049, EBI-742740;
CC       Q13895; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-358049, EBI-14104088;
CC       Q13895; Q9NTW7: ZFP64; NbExp=5; IntAct=EBI-358049, EBI-711679;
CC       Q13895; Q9UDW3: ZMAT5; NbExp=3; IntAct=EBI-358049, EBI-7850213;
CC       Q13895; Q9UDV6: ZNF212; NbExp=3; IntAct=EBI-358049, EBI-1640204;
CC       Q13895; Q9HBT8: ZNF286A; NbExp=3; IntAct=EBI-358049, EBI-10754950;
CC       Q13895; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-358049, EBI-743265;
CC       Q13895; Q9C0F3: ZNF436; NbExp=3; IntAct=EBI-358049, EBI-8489702;
CC       Q13895; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-358049, EBI-11962468;
CC       Q13895; Q96MX3: ZNF48; NbExp=3; IntAct=EBI-358049, EBI-12006434;
CC       Q13895; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-358049, EBI-745520;
CC       Q13895; Q8N720: ZNF655; NbExp=3; IntAct=EBI-358049, EBI-625509;
CC       Q13895; Q96K58-2: ZNF668; NbExp=3; IntAct=EBI-358049, EBI-12817597;
CC       Q13895; Q9NQZ8: ZNF71; NbExp=3; IntAct=EBI-358049, EBI-7138235;
CC       Q13895; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-358049, EBI-10251462;
CC       Q13895; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-358049, EBI-5667516;
CC       Q13895; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-358049, EBI-527853;
CC       Q13895; P10073: ZSCAN22; NbExp=3; IntAct=EBI-358049, EBI-10178224;
CC       Q13895; P0DTC9: N; Xeno; NbExp=4; IntAct=EBI-358049, EBI-25475856;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17381424}. Nucleus,
CC       nucleolus {ECO:0000269|PubMed:17381424, ECO:0000269|PubMed:26711351}.
CC       Note=Associated with 40S ribosomal subunits.
CC   -!- TISSUE SPECIFICITY: Found in the placenta from the sixth week of
CC       pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in
CC       the chorionic villi and in endometrial decidual cells at the
CC       uteroplacental interface. After week 10, the level decreased and then
CC       disappeared from placental villi.
CC   -!- MISCELLANEOUS: HeLa cells lacking BYSL show a delay in the processing
CC       of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells
CC       lacking BYSL show trophinin-independent signaling through ERBB4.
CC   -!- SIMILARITY: Belongs to the bystin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC16603.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC007340; AAH07340.3; -; mRNA.
DR   EMBL; BC050645; AAH50645.1; -; mRNA.
DR   EMBL; BC062627; AAH62627.2; -; mRNA.
DR   EMBL; L36720; AAC16603.2; ALT_INIT; mRNA.
DR   CCDS; CCDS34450.1; -.
DR   RefSeq; NP_004044.3; NM_004053.3.
DR   PDB; 6G18; EM; 3.60 A; w=1-437.
DR   PDB; 6G4S; EM; 4.00 A; w=1-437.
DR   PDB; 6G4W; EM; 4.50 A; w=1-437.
DR   PDBsum; 6G18; -.
DR   PDBsum; 6G4S; -.
DR   PDBsum; 6G4W; -.
DR   AlphaFoldDB; Q13895; -.
DR   SMR; Q13895; -.
DR   BioGRID; 107167; 270.
DR   DIP; DIP-50092N; -.
DR   IntAct; Q13895; 188.
DR   MINT; Q13895; -.
DR   STRING; 9606.ENSP00000230340; -.
DR   GlyGen; Q13895; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q13895; -.
DR   MetOSite; Q13895; -.
DR   PhosphoSitePlus; Q13895; -.
DR   SwissPalm; Q13895; -.
DR   BioMuta; BYSL; -.
DR   DMDM; 108884834; -.
DR   SWISS-2DPAGE; Q13895; -.
DR   EPD; Q13895; -.
DR   jPOST; Q13895; -.
DR   MassIVE; Q13895; -.
DR   MaxQB; Q13895; -.
DR   PaxDb; Q13895; -.
DR   PeptideAtlas; Q13895; -.
DR   PRIDE; Q13895; -.
DR   ProteomicsDB; 59718; -.
DR   Antibodypedia; 30110; 82 antibodies from 17 providers.
DR   DNASU; 705; -.
DR   Ensembl; ENST00000230340.9; ENSP00000230340.4; ENSG00000112578.10.
DR   GeneID; 705; -.
DR   KEGG; hsa:705; -.
DR   MANE-Select; ENST00000230340.9; ENSP00000230340.4; NM_004053.4; NP_004044.3.
DR   UCSC; uc003orl.4; human.
DR   CTD; 705; -.
DR   DisGeNET; 705; -.
DR   GeneCards; BYSL; -.
DR   HGNC; HGNC:1157; BYSL.
DR   HPA; ENSG00000112578; Low tissue specificity.
DR   MIM; 603871; gene.
DR   neXtProt; NX_Q13895; -.
DR   OpenTargets; ENSG00000112578; -.
DR   PharmGKB; PA25472; -.
DR   VEuPathDB; HostDB:ENSG00000112578; -.
DR   eggNOG; KOG3871; Eukaryota.
DR   GeneTree; ENSGT00390000007241; -.
DR   HOGENOM; CLU_029727_0_0_1; -.
DR   InParanoid; Q13895; -.
DR   OMA; AGGQEKH; -.
DR   OrthoDB; 1193442at2759; -.
DR   PhylomeDB; Q13895; -.
DR   TreeFam; TF312968; -.
DR   PathwayCommons; Q13895; -.
DR   Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   SignaLink; Q13895; -.
DR   BioGRID-ORCS; 705; 735 hits in 1085 CRISPR screens.
DR   ChiTaRS; BYSL; human.
DR   GeneWiki; BYSL; -.
DR   GenomeRNAi; 705; -.
DR   Pharos; Q13895; Tbio.
DR   PRO; PR:Q13895; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q13895; protein.
DR   Bgee; ENSG00000112578; Expressed in gastrocnemius and 119 other tissues.
DR   ExpressionAtlas; Q13895; baseline and differential.
DR   Genevisible; Q13895; HS.
DR   GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR   GO; GO:0005694; C:chromosome; IDA:HPA.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Ensembl.
DR   GO; GO:1904749; P:regulation of protein localization to nucleolus; ISS:UniProtKB.
DR   GO; GO:0042254; P:ribosome biogenesis; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR   GO; GO:0001829; P:trophectodermal cell differentiation; IEA:Ensembl.
DR   InterPro; IPR007955; Bystin.
DR   PANTHER; PTHR12821; PTHR12821; 1.
DR   Pfam; PF05291; Bystin; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Methylation; Nucleus; Phosphoprotein;
KW   Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..437
FT                   /note="Bystin"
FT                   /id="PRO_0000186114"
FT   REGION          1..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         40
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0007744|PubMed:24129315"
FT   MOD_RES         55
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         98
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:17081983,
FT                   ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648,
FT                   ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332,
FT                   ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT                   ECO:0007744|PubMed:23186163"
FT   MOD_RES         156
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         167
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19690332"
FT   MOD_RES         414
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VARIANT         103
FT                   /note="E -> K (in dbSNP:rs2296916)"
FT                   /id="VAR_033641"
FT   VARIANT         426
FT                   /note="P -> S (in dbSNP:rs3828855)"
FT                   /id="VAR_048439"
FT   CONFLICT        214
FT                   /note="E -> D (in Ref. 1; AAH07340)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        263
FT                   /note="A -> G (in Ref. 2; AAC16603)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   437 AA;  49601 MW;  1A8C5E5EB108DF1A CRC64;
     MPKFKAARGV GGQEKHAPLA DQILAGNAVR AGVREKRRGR GTGEAEEEYV GPRLSRRILQ
     QARQQQEELE AEHGTGDKPA APRERTTRLG PRMPQDGSDD EDEEWPTLEK AATMTAAGHH
     AEVVVDPEDE RAIEMFMNKN PPARRTLADI IMEKLTEKQT EVETVMSEVS GFPMPQLDPR
     VLEVYRGVRE VLSKYRSGKL PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN
     LKERMAQRFY NLVLLPRVRD DVAEYKRLNF HLYMALKKAL FKPGAWFKGI LIPLCESGTC
     TLREAIIVGS IITKCSIPVL HSSAAMLKIA EMEYSGANSI FLRLLLDKKY ALPYRVLDAL
     VFHFLGFRTE KRELPVLWHQ CLLTLVQRYK ADLATDQKEA LLELLRLQPH PQLSPEIRRE
     LQSAVPRDVE DVPITVE
 
 
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