BYS_DROME
ID BYS_DROME Reviewed; 436 AA.
AC P51406; Q9W3N3;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Bystin;
DE AltName: Full=Protein bys;
GN Name=bys; ORFNames=CG1430;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-240.
RA Stewart M.J., Denell R.;
RL Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
RX PubMed=8384310; DOI=10.1128/mcb.13.4.2524-2535.1993;
RA Stewart M.J., Denell R.;
RT "Mutations in the Drosophila gene encoding ribosomal protein S6 cause
RT tissue overgrowth.";
RL Mol. Cell. Biol. 13:2524-2535(1993).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-145; SER-148 AND SER-152, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Required for processing of 20S pre-rRNA precursor and
CC biogenesis of 40S ribosomal subunits. {ECO:0000250|UniProtKB:Q13895}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q13895}.
CC -!- SIMILARITY: Belongs to the bystin family. {ECO:0000305}.
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DR EMBL; AE014298; AAF46289.1; -; Genomic_DNA.
DR EMBL; AY061176; AAL28724.1; -; mRNA.
DR EMBL; L02076; AAA28401.1; -; mRNA.
DR EMBL; L02074; AAD20894.1; -; Genomic_DNA.
DR RefSeq; NP_511074.1; NM_078519.3.
DR AlphaFoldDB; P51406; -.
DR SMR; P51406; -.
DR BioGRID; 58175; 1.
DR DIP; DIP-19855N; -.
DR IntAct; P51406; 8.
DR STRING; 7227.FBpp0071046; -.
DR iPTMnet; P51406; -.
DR PaxDb; P51406; -.
DR PRIDE; P51406; -.
DR DNASU; 31701; -.
DR EnsemblMetazoa; FBtr0071090; FBpp0071046; FBgn0010292.
DR GeneID; 31701; -.
DR KEGG; dme:Dmel_CG1430; -.
DR CTD; 31701; -.
DR FlyBase; FBgn0010292; bys.
DR VEuPathDB; VectorBase:FBgn0010292; -.
DR eggNOG; KOG3871; Eukaryota.
DR GeneTree; ENSGT00390000007241; -.
DR HOGENOM; CLU_029727_0_1_1; -.
DR InParanoid; P51406; -.
DR OMA; AGGQEKH; -.
DR OrthoDB; 1193442at2759; -.
DR PhylomeDB; P51406; -.
DR BioGRID-ORCS; 31701; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 31701; -.
DR PRO; PR:P51406; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0010292; Expressed in adult abdomen and 47 other tissues.
DR Genevisible; P51406; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR InterPro; IPR007955; Bystin.
DR PANTHER; PTHR12821; PTHR12821; 1.
DR Pfam; PF05291; Bystin; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..436
FT /note="Bystin"
FT /id="PRO_0000186116"
FT MOD_RES 145
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 148
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 222..240
FT /note="LSQAMAQRFYNLVLLPRVR -> ARVAGNGPRGSITWCSCHE (in Ref.
FT 4; AAA28401)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 436 AA; 49967 MW; 62616795138A305D CRC64;
MGKPKKANVA TIKNVNLEKQ ITEGRVAKNK NKDKVKLRAE ESANIDARSS QKILAAAKLQ
QLELDEENFP SLVTVKKVNF SLNDGHVKED EEVNETDLMA DLDMDEDDVA AFERFQQPAQ
EGKRTLHLSK MIMQKIQEKE ADIHTKISDE GSLKIEEIDP KVKEMYEGVR DVLKRYRSGK
IPKAFKIIPK LRNWEQILFI TEPHNWSAAA MFQGTRIFCS VLSQAMAQRF YNLVLLPRVR
DDLCEYKKLN MHLYNALKRA LFKPAAFMKG IILPLLEGGD CTLREAIIFG SVVARSSIPV
LHSSACLLKI CEMAYSGANS IFIRYFLDKR YALPYRVVDA AVFHFLRFEN DKRELPVLWH
QSLLTFAQRY KNDISSEQRD ALLQLLKKKS HFKITPDVRR ELQAASCRDV EMMETDNGLA
GQPAKMYTDA DVEYEG
