BZIP2_ARATH
ID BZIP2_ARATH Reviewed; 171 AA.
AC Q9SI15; Q9FVN9;
DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=bZIP transcription factor 2 {ECO:0000305};
DE Short=AtbZIP2 {ECO:0000303|PubMed:11906833};
DE AltName: Full=G-box-binding factor 5 {ECO:0000303|Ref.1};
DE AltName: Full=Protein FLORAL TRANSITION AT THE MERISTEM 3 {ECO:0000303|PubMed:22319055};
GN Name=BZIP2 {ECO:0000303|PubMed:11906833};
GN Synonyms=FTM3 {ECO:0000303|PubMed:22319055}, GBF5 {ECO:0000303|Ref.1};
GN OrderedLocusNames=At2g18160 {ECO:0000312|Araport:AT2G18160};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Jarillo J.A., Cashmore A.R.;
RT "GBF5 and GBF6: two bZIP proteins from Arabidopsis that belong to a new
RT subfamily of the GBF transcription factors.";
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11906833; DOI=10.1016/s1360-1385(01)02223-3;
RA Jakoby M., Weisshaar B., Droege-Laser W., Vicente-Carbajosa J.,
RA Tiedemann J., Kroj T., Parcy F.;
RT "bZIP transcription factors in Arabidopsis.";
RL Trends Plant Sci. 7:106-111(2002).
RN [6]
RP INTERACTION WITH BZIP9; BZIP10; BZIP25 AND BZIP63.
RX PubMed=16709202; DOI=10.1111/j.1365-313x.2006.02731.x;
RA Ehlert A., Weltmeier F., Wang X., Mayer C.S., Smeekens S.,
RA Vicente-Carbajosa J., Droege-Laser W.;
RT "Two-hybrid protein-protein interaction analysis in Arabidopsis
RT protoplasts: establishment of a heterodimerization map of group C and group
RT S bZIP transcription factors.";
RL Plant J. 46:890-900(2006).
RN [7]
RP DEVELOPMENTAL STAGE.
RX PubMed=22319055; DOI=10.1105/tpc.111.092791;
RA Torti S., Fornara F., Vincent C., Andres F., Nordstrom K., Gobel U.,
RA Knoll D., Schoof H., Coupland G.;
RT "Analysis of the Arabidopsis shoot meristem transcriptome during floral
RT transition identifies distinct regulatory patterns and a leucine-rich
RT repeat protein that promotes flowering.";
RL Plant Cell 24:444-462(2012).
RN [8]
RP INTERACTION WITH KIN10 AND BZIP63, AND FUNCTION.
RX PubMed=29348240; DOI=10.1105/tpc.17.00414;
RA Pedrotti L., Weiste C., Naegele T., Wolf E., Lorenzin F., Dietrich K.,
RA Mair A., Weckwerth W., Teige M., Baena-Gonzalez E., Droege-Laser W.;
RT "Snf1-RELATED KINASE1-controlled C/S1-bZIP signaling activates alternative
RT mitochondrial metabolic pathways to ensure plant survival in extended
RT darkness.";
RL Plant Cell 30:495-509(2018).
CC -!- FUNCTION: Transcription factor that binds to specific DNA sequences in
CC target gene promoters. BZIP2-BZIP63-KIN10 complex binds to the ETFQO
CC promoter to up-regulate its transcription (PubMed:29348240).
CC {ECO:0000250|UniProtKB:O65683, ECO:0000269|PubMed:29348240}.
CC -!- SUBUNIT: Forms heterodimers with BZIP9, BZIP10, BZIP25 and BZIP63
CC (PubMed:16709202). Component of a ternary complex composed of BZIP2-
CC BZIP63 heterodimer and KIN10 (PubMed:29348240).
CC {ECO:0000269|PubMed:16709202, ECO:0000269|PubMed:29348240}.
CC -!- INTERACTION:
CC Q9SI15; O22763: BZIP10; NbExp=3; IntAct=EBI-942735, EBI-942648;
CC Q9SI15; Q9M1G6: BZIP25; NbExp=6; IntAct=EBI-942735, EBI-942696;
CC Q9SI15; Q9LZP8: BZIP53; NbExp=3; IntAct=EBI-942735, EBI-942845;
CC Q9SI15; B9DGI8: BZIP63; NbExp=4; IntAct=EBI-942735, EBI-942713;
CC Q9SI15; Q9FUD3: BZIP9; NbExp=3; IntAct=EBI-942735, EBI-942633;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the shoot meristem during vegetative
CC to reproductive phase transition. {ECO:0000269|PubMed:22319055}.
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DR EMBL; AF053939; AAG17474.1; -; mRNA.
DR EMBL; AC007212; AAD31350.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06732.1; -; Genomic_DNA.
DR EMBL; AY037216; AAK59801.1; -; mRNA.
DR EMBL; AY133545; AAM91375.1; -; mRNA.
DR EMBL; BT000700; AAN31844.1; -; mRNA.
DR PIR; A84561; A84561.
DR RefSeq; NP_179408.1; NM_127373.2.
DR AlphaFoldDB; Q9SI15; -.
DR SMR; Q9SI15; -.
DR IntAct; Q9SI15; 11.
DR MINT; Q9SI15; -.
DR STRING; 3702.AT2G18160.1; -.
DR PaxDb; Q9SI15; -.
DR PRIDE; Q9SI15; -.
DR ProteomicsDB; 240416; -.
DR EnsemblPlants; AT2G18160.1; AT2G18160.1; AT2G18160.
DR GeneID; 816329; -.
DR Gramene; AT2G18160.1; AT2G18160.1; AT2G18160.
DR KEGG; ath:AT2G18160; -.
DR Araport; AT2G18160; -.
DR TAIR; locus:2053124; AT2G18160.
DR eggNOG; ENOG502S0BS; Eukaryota.
DR HOGENOM; CLU_112634_1_0_1; -.
DR InParanoid; Q9SI15; -.
DR OMA; DDMNMMS; -.
DR OrthoDB; 1624574at2759; -.
DR PhylomeDB; Q9SI15; -.
DR PRO; PR:Q9SI15; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SI15; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd14702; bZIP_plant_GBF1; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR045314; bZIP_plant_GBF1.
DR InterPro; IPR046347; bZIP_sf.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..171
FT /note="bZIP transcription factor 2"
FT /id="PRO_0000436839"
FT DOMAIN 29..92
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 31..52
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 57..71
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 18
FT /note="N -> I (in Ref. 1; AAG17474)"
FT /evidence="ECO:0000305"
FT CONFLICT 48..52
FT /note="MRKQK -> VRKQE (in Ref. 1; AAG17474)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 171 AA; 19104 MW; DA38B39D8D39ADA4 CRC64;
MASSSSTYRS SSSSDGGNNN PSDSVVTVDE RKRKRMLSNR ESARRSRMRK QKHVDDLTAQ
INQLSNDNRQ ILNSLTVTSQ LYMKIQAENS VLTAQMEELS TRLQSLNEIV DLVQSNGAGF
GVDQIDGCGF DDRTVGIDGY YDDMNMMSNV NHWGGSVYTN QPIMANDINM Y
