ID   TRNH4_ARATH             Reviewed;         268 AA.
AC   Q9ZW04; F4IJR7;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Tropinone reductase homolog At2g29170 {ECO:0000305};
DE            EC=1.1.1.- {ECO:0000305};
GN   OrderedLocusNames=At2g29170 {ECO:0000312|EMBL:AAC95218.1};
GN   ORFNames=F16P2 {ECO:0000312|EMBL:AAC95218.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia {ECO:0000312|Proteomes:UP000006548};
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19027726; DOI=10.1016/j.cbi.2008.10.040;
RA   Persson B., Kallberg Y., Bray J.E., Bruford E., Dellaporta S.L.,
RA   Favia A.D., Duarte R.G., Joernvall H., Kavanagh K.L., Kedishvili N.,
RA   Kisiela M., Maser E., Mindnich R., Orchard S., Penning T.M., Thornton J.M.,
RA   Adamski J., Oppermann U.;
RT   "The SDR (short-chain dehydrogenase/reductase and related enzymes)
RT   nomenclature initiative.";
RL   Chem. Biol. Interact. 178:94-98(2009).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. SDR65C subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AEC08218.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC004561; AAC95218.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC08218.1; ALT_SEQ; Genomic_DNA.
DR   PIR; C84693; C84693.
DR   RefSeq; NP_180480.2; NM_128473.4.
DR   AlphaFoldDB; Q9ZW04; -.
DR   SMR; Q9ZW04; -.
DR   STRING; 3702.AT2G29170.1; -.
DR   PRIDE; Q9ZW04; -.
DR   GeneID; 817466; -.
DR   KEGG; ath:AT2G29170; -.
DR   Araport; AT2G29170; -.
DR   TAIR; locus:2043197; AT2G29170.
DR   OrthoDB; 1194344at2759; -.
DR   PRO; PR:Q9ZW04; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9ZW04; baseline and differential.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   InterPro; IPR045000; TR.
DR   PANTHER; PTHR42898; PTHR42898; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..268
FT                   /note="Tropinone reductase homolog At2g29170"
FT                   /id="PRO_0000432359"
FT   ACT_SITE        168
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         22..46
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250|UniProtKB:P50162"
FT   BINDING         155
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P50162"
SQ   SEQUENCE   268 AA;  28999 MW;  A3E9DDE603ADFD37 CRC64;
     MAKAEENLRD KCRWSLGGMT ALVTGGSKGL GEAVVEELAM LGARVHTCAR NETQLQECVR
     EWQAKGFEVT TSVCDVSSRD QREKLMENVA SIFQGKLNIL VNNAGTGITK PTTEYTAQDY
     SFLMATNLDS AFHLSQLAHP LLKASGSGSI VLMSSTAGVV HINVGSIYGA TKGAMNQLAK
     NLACEWARDN IRVNSVCPWF IATPLYLNDE ELKKEVERKT PMGRVGNANE VSSLVAFLCF
     PAASYITGQT ICVDGGFTVN CFSFKPVL