TRNHB_ARATH
ID TRNHB_ARATH Reviewed; 307 AA.
AC F4IKM1; B9DF84; Q94C81; Q9ZW17;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Tropinone reductase homolog At2g29340 {ECO:0000305};
DE EC=1.1.1.- {ECO:0000305};
GN OrderedLocusNames=At2g29340 {ECO:0000312|Araport:AT2G29340};
GN ORFNames=F16P2.28 {ECO:0000312|EMBL:AAC95204.2};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000312|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19027726; DOI=10.1016/j.cbi.2008.10.040;
RA Persson B., Kallberg Y., Bray J.E., Bruford E., Dellaporta S.L.,
RA Favia A.D., Duarte R.G., Joernvall H., Kavanagh K.L., Kedishvili N.,
RA Kisiela M., Maser E., Mindnich R., Orchard S., Penning T.M., Thornton J.M.,
RA Adamski J., Oppermann U.;
RT "The SDR (short-chain dehydrogenase/reductase and related enzymes)
RT nomenclature initiative.";
RL Chem. Biol. Interact. 178:94-98(2009).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=F4IKM1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4IKM1-2; Sequence=VSP_057496, VSP_057497;
CC Name=3;
CC IsoId=F4IKM1-3; Sequence=VSP_057498;
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. SDR65C subfamily. {ECO:0000305}.
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DR EMBL; AC004561; AAC95204.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC08236.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08237.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08238.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61994.1; -; Genomic_DNA.
DR EMBL; AY035093; AAK59598.1; -; mRNA.
DR EMBL; AK316672; BAH19401.1; -; mRNA.
DR PIR; B84695; B84695.
DR RefSeq; NP_001118409.1; NM_001124937.2. [F4IKM1-2]
DR RefSeq; NP_001324177.1; NM_001336209.1. [F4IKM1-2]
DR RefSeq; NP_565680.2; NM_128488.4. [F4IKM1-1]
DR RefSeq; NP_850131.1; NM_179800.3. [F4IKM1-3]
DR AlphaFoldDB; F4IKM1; -.
DR SMR; F4IKM1; -.
DR IntAct; F4IKM1; 1.
DR STRING; 3702.AT2G29340.1; -.
DR PaxDb; F4IKM1; -.
DR PRIDE; F4IKM1; -.
DR ProteomicsDB; 234326; -. [F4IKM1-1]
DR EnsemblPlants; AT2G29340.1; AT2G29340.1; AT2G29340. [F4IKM1-1]
DR EnsemblPlants; AT2G29340.2; AT2G29340.2; AT2G29340. [F4IKM1-3]
DR EnsemblPlants; AT2G29340.3; AT2G29340.3; AT2G29340. [F4IKM1-2]
DR EnsemblPlants; AT2G29340.4; AT2G29340.4; AT2G29340. [F4IKM1-2]
DR GeneID; 817483; -.
DR Gramene; AT2G29340.1; AT2G29340.1; AT2G29340. [F4IKM1-1]
DR Gramene; AT2G29340.2; AT2G29340.2; AT2G29340. [F4IKM1-3]
DR Gramene; AT2G29340.3; AT2G29340.3; AT2G29340. [F4IKM1-2]
DR Gramene; AT2G29340.4; AT2G29340.4; AT2G29340. [F4IKM1-2]
DR KEGG; ath:AT2G29340; -.
DR Araport; AT2G29340; -.
DR TAIR; locus:2042982; AT2G29340.
DR eggNOG; KOG0725; Eukaryota.
DR InParanoid; F4IKM1; -.
DR OMA; CGLANIN; -.
DR OrthoDB; 1074094at2759; -.
DR PhylomeDB; F4IKM1; -.
DR PRO; PR:F4IKM1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IKM1; baseline and differential.
DR Genevisible; F4IKM1; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005777; C:peroxisome; HDA:TAIR.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR InterPro; IPR045000; TR.
DR PANTHER; PTHR42898; PTHR42898; 2.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..307
FT /note="Tropinone reductase homolog At2g29340"
FT /id="PRO_0000432366"
FT ACT_SITE 159
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 13..37
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:P50162"
FT BINDING 146
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:P50162"
FT VAR_SEQ 200..202
FT /note="YLE -> VIN (in isoform 2)"
FT /id="VSP_057496"
FT VAR_SEQ 203..307
FT /note="Missing (in isoform 2)"
FT /id="VSP_057497"
FT VAR_SEQ 261..305
FT /note="Missing (in isoform 3)"
FT /id="VSP_057498"
SQ SEQUENCE 307 AA; 32900 MW; 9737C56744C79237 CRC64;
MDKRWSLKGM TALVTGGASG IGYAIVEELA GFGARIHVCD ISEAKLNQSL SEWEKKGFQV
SGSVCDVASR PEREELMQTV SSQFDGKLNI LVSNVGVIRS KPTTEYTEDD FAFHISSNVE
AAYHFSQLSH PLLKASGYGS IIFVSSIAGV ISFDAGSIYG LTKGALIQLA KNLACEWAKD
GIRANAVAPN VINTPLSQSY LEDVSFKKAL LSRTPLGRVG EPNEVASLVA FLCLPAASYI
TGQTICVDGG LTVNGFSYQP EEALLSRTSL RRVGEPNEVS SLVVFLCLPA ASYITGQMVK
PFVLMEV
