ID   TRNHD_ARATH             Reviewed;         268 AA.
AC   Q9ZW20;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Tropinone reductase homolog At2g29370 {ECO:0000305};
DE            EC=1.1.1.- {ECO:0000305};
GN   OrderedLocusNames=At2g29370 {ECO:0000312|Araport:AT2G29370};
GN   ORFNames=F16P2.25 {ECO:0000312|EMBL:AAC95201.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19027726; DOI=10.1016/j.cbi.2008.10.040;
RA   Persson B., Kallberg Y., Bray J.E., Bruford E., Dellaporta S.L.,
RA   Favia A.D., Duarte R.G., Joernvall H., Kavanagh K.L., Kedishvili N.,
RA   Kisiela M., Maser E., Mindnich R., Orchard S., Penning T.M., Thornton J.M.,
RA   Adamski J., Oppermann U.;
RT   "The SDR (short-chain dehydrogenase/reductase and related enzymes)
RT   nomenclature initiative.";
RL   Chem. Biol. Interact. 178:94-98(2009).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. SDR65C subfamily. {ECO:0000305}.
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DR   EMBL; AC004561; AAC95201.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC08243.1; -; Genomic_DNA.
DR   PIR; E84695; E84695.
DR   RefSeq; NP_850132.2; NM_179801.3.
DR   AlphaFoldDB; Q9ZW20; -.
DR   SMR; Q9ZW20; -.
DR   STRING; 3702.AT2G29370.1; -.
DR   PaxDb; Q9ZW20; -.
DR   PRIDE; Q9ZW20; -.
DR   ProteomicsDB; 232446; -.
DR   EnsemblPlants; AT2G29370.1; AT2G29370.1; AT2G29370.
DR   GeneID; 817486; -.
DR   Gramene; AT2G29370.1; AT2G29370.1; AT2G29370.
DR   KEGG; ath:AT2G29370; -.
DR   Araport; AT2G29370; -.
DR   TAIR; locus:2043152; AT2G29370.
DR   eggNOG; KOG0725; Eukaryota.
DR   HOGENOM; CLU_010194_1_1_1; -.
DR   InParanoid; Q9ZW20; -.
DR   OMA; VNICTEG; -.
DR   OrthoDB; 1194344at2759; -.
DR   PhylomeDB; Q9ZW20; -.
DR   BioCyc; ARA:AT2G29370-MON; -.
DR   PRO; PR:Q9ZW20; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9ZW20; baseline and differential.
DR   Genevisible; Q9ZW20; AT.
DR   GO; GO:0005829; C:cytosol; HDA:TAIR.
DR   GO; GO:0005777; C:peroxisome; HDA:TAIR.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   InterPro; IPR045000; TR.
DR   PANTHER; PTHR42898; PTHR42898; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..268
FT                   /note="Tropinone reductase homolog At2g29370"
FT                   /id="PRO_0000432368"
FT   ACT_SITE        168
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         22..46
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250|UniProtKB:P50162"
FT   BINDING         155
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P50162"
SQ   SEQUENCE   268 AA;  28721 MW;  94174F41ED1653CE CRC64;
     MAKRGESLRD KPKWSLEGMT ALVTGGSKGL GKAVVEELAM LGARVHTCAR DETQLQESLR
     EWQAKGLQVT TSVCDVSSRD QREKLMETVS SLFQGKLSIL VPNVGIGVLK PTTECTAEEF
     SFIIATNLES TFHFSQLAHP LLKASGSGNI VLMSSVAGVV NLGNTSIYGA TKGAMNQLAR
     NLACEWASDN IRANSVCPWF ITTPSTKDFL GDKDVKEKVE SVTPLRRVGE ANEVSSLVAF
     LCLPAASYIT GQTICVDGGF TINGFSLP