TRNHF_ARATH
ID TRNHF_ARATH Reviewed; 264 AA.
AC Q9LHT0; Q8LFZ4;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Tropinone reductase homolog At5g06060 {ECO:0000305};
DE EC=1.1.1.- {ECO:0000305};
GN OrderedLocusNames=At5g06060 {ECO:0000312|Araport:AT5G06060};
GN ORFNames=K16F4.2 {ECO:0000312|EMBL:BAA98195.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAA98195.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19027726; DOI=10.1016/j.cbi.2008.10.040;
RA Persson B., Kallberg Y., Bray J.E., Bruford E., Dellaporta S.L.,
RA Favia A.D., Duarte R.G., Joernvall H., Kavanagh K.L., Kedishvili N.,
RA Kisiela M., Maser E., Mindnich R., Orchard S., Penning T.M., Thornton J.M.,
RA Adamski J., Oppermann U.;
RT "The SDR (short-chain dehydrogenase/reductase and related enzymes)
RT nomenclature initiative.";
RL Chem. Biol. Interact. 178:94-98(2009).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. SDR65C subfamily. {ECO:0000305}.
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DR EMBL; AP002030; BAA98195.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90960.1; -; Genomic_DNA.
DR EMBL; BT002894; AAO22710.1; -; mRNA.
DR EMBL; BT004454; AAO42448.1; -; mRNA.
DR EMBL; AY084550; AAM61117.1; -; mRNA.
DR RefSeq; NP_196225.1; NM_120688.3.
DR AlphaFoldDB; Q9LHT0; -.
DR SMR; Q9LHT0; -.
DR IntAct; Q9LHT0; 4.
DR STRING; 3702.AT5G06060.1; -.
DR PaxDb; Q9LHT0; -.
DR PRIDE; Q9LHT0; -.
DR ProteomicsDB; 232447; -.
DR EnsemblPlants; AT5G06060.1; AT5G06060.1; AT5G06060.
DR GeneID; 830493; -.
DR Gramene; AT5G06060.1; AT5G06060.1; AT5G06060.
DR KEGG; ath:AT5G06060; -.
DR Araport; AT5G06060; -.
DR TAIR; locus:2152815; AT5G06060.
DR eggNOG; KOG0725; Eukaryota.
DR HOGENOM; CLU_010194_1_1_1; -.
DR InParanoid; Q9LHT0; -.
DR OMA; RIWDSKV; -.
DR OrthoDB; 1194344at2759; -.
DR PhylomeDB; Q9LHT0; -.
DR BioCyc; ARA:AT5G06060-MON; -.
DR PRO; PR:Q9LHT0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LHT0; baseline and differential.
DR Genevisible; Q9LHT0; AT.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR InterPro; IPR045000; TR.
DR PANTHER; PTHR42898; PTHR42898; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 2: Evidence at transcript level;
KW NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..264
FT /note="Tropinone reductase homolog At5g06060"
FT /id="PRO_0000432370"
FT ACT_SITE 161
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 15..39
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250|UniProtKB:P50162"
FT BINDING 148
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:P50162"
FT CONFLICT 35
FT /note="G -> C (in Ref. 4; AAM61117)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 264 AA; 28292 MW; CD8F1F3DFB7EB463 CRC64;
METDKRWSLA GKTALVTGGT RGIGRAVVEE LAKFGAKVHT CSRNQEELNA CLNDWKANGL
VVSGSVCDAS VRDQREKLIQ EASSAFSGKL NILINNVGTN VRKPTVEYSS EEYAKIMSTN
LESAFHLSQI AHPLLKASGV GSIVFISSVA GLVHLSSGSI YGATKGALNQ LTRNLACEWA
SDNIRTNCVA PWYIKTSLVE TLLEKKEFVE AVVSRTPLGR VGEPEEVSSL VAFLCLPASS
YITGQVISVD GGFTVNGFSY AMKP
