ID   TRNH_DATST              Reviewed;         268 AA.
AC   P50165;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Tropinone reductase homolog;
DE            EC=1.1.1.-;
DE   AltName: Full=P29X;
OS   Datura stramonium (Jimsonweed) (Common thornapple).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Datureae; Datura.
OX   NCBI_TaxID=4076;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Root;
RX   PubMed=8415746; DOI=10.1073/pnas.90.20.9591;
RA   Nakajima K., Hashimoto T., Yamada Y.;
RT   "Two tropinone reductases with different stereospecificities are short-
RT   chain dehydrogenases evolved from a common ancestor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:9591-9595(1993).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; L20475; AAA33280.1; -; mRNA.
DR   PIR; C48674; C48674.
DR   AlphaFoldDB; P50165; -.
DR   SMR; P50165; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   InterPro; IPR045000; TR.
DR   PANTHER; PTHR42898; PTHR42898; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase.
FT   CHAIN           1..268
FT                   /note="Tropinone reductase homolog"
FT                   /id="PRO_0000054788"
FT   ACT_SITE        167
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         21..45
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         154
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   268 AA;  28589 MW;  6766AF835BD3C06E CRC64;
     MAGREIGGGD RRWSLRGMTA LVTGGTRGIG YAIVEELANF GAEVYTCSRS QNDLDECLEK
     WRRKGFKVSG PVCDVSSISQ RQTLMESVTS SFNGKLNILI NNAGTTIPKE ATNFTAEDYS
     IIMGTNFEAS YNLCQLAHPL LKASGNASIV FNSSAAGVIA VPLSSIYAAS KGAINQVTKS
     LACEWAKDSI RVNAVAPWII NTPIIEAACQ VPSQKKNIES LIGRAPMKRA GEPSEVSSLV
     TYLCLPTASY ITGQIICVDG GYTVNGFI