ID   TRNK1_HUMAN             Reviewed;        2925 AA.
AC   O15050; Q8N8K0;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 4.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=TPR and ankyrin repeat-containing protein 1;
DE   AltName: Full=Lupus brain antigen 1 homolog;
GN   Name=TRANK1; Synonyms=KIAA0342, LBA1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 459-2925, AND VARIANT GLY-1090.
RC   TISSUE=Brain;
RX   PubMed=9205841; DOI=10.1093/dnares/4.2.141;
RA   Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N.,
RA   Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. VII. The
RT   complete sequences of 100 new cDNA clones from brain which can code for
RT   large proteins in vitro.";
RL   DNA Res. 4:141-150(1997).
RN   [3]
RP   SEQUENCE REVISION.
RX   PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 713-1525, AND VARIANT GLY-1090.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC04838.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC097360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC105749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB002340; BAA20800.3; -; mRNA.
DR   EMBL; AK096678; BAC04838.1; ALT_INIT; mRNA.
DR   CCDS; CCDS46789.2; -.
DR   RefSeq; NP_055646.2; NM_014831.2.
DR   SMR; O15050; -.
DR   BioGRID; 115212; 3.
DR   IntAct; O15050; 3.
DR   STRING; 9606.ENSP00000416168; -.
DR   iPTMnet; O15050; -.
DR   PhosphoSitePlus; O15050; -.
DR   BioMuta; TRANK1; -.
DR   EPD; O15050; -.
DR   jPOST; O15050; -.
DR   MassIVE; O15050; -.
DR   MaxQB; O15050; -.
DR   PaxDb; O15050; -.
DR   PeptideAtlas; O15050; -.
DR   PRIDE; O15050; -.
DR   ProteomicsDB; 48402; -.
DR   Antibodypedia; 51967; 13 antibodies from 8 providers.
DR   DNASU; 9881; -.
DR   Ensembl; ENST00000429976.5; ENSP00000416168.2; ENSG00000168016.15.
DR   GeneID; 9881; -.
DR   KEGG; hsa:9881; -.
DR   UCSC; uc003cgj.4; human.
DR   CTD; 9881; -.
DR   DisGeNET; 9881; -.
DR   GeneCards; TRANK1; -.
DR   HGNC; HGNC:29011; TRANK1.
DR   HPA; ENSG00000168016; Tissue enhanced (fallopian).
DR   MIM; 619316; gene.
DR   neXtProt; NX_O15050; -.
DR   OpenTargets; ENSG00000168016; -.
DR   Orphanet; 33543; Kleine-Levin syndrome.
DR   PharmGKB; PA165698606; -.
DR   VEuPathDB; HostDB:ENSG00000168016; -.
DR   eggNOG; ENOG502QQZC; Eukaryota.
DR   GeneTree; ENSGT00940000153370; -.
DR   HOGENOM; CLU_227614_0_0_1; -.
DR   InParanoid; O15050; -.
DR   OrthoDB; 5008at2759; -.
DR   PhylomeDB; O15050; -.
DR   TreeFam; TF335821; -.
DR   PathwayCommons; O15050; -.
DR   SignaLink; O15050; -.
DR   BioGRID-ORCS; 9881; 5 hits in 1048 CRISPR screens.
DR   ChiTaRS; TRANK1; human.
DR   GenomeRNAi; 9881; -.
DR   Pharos; O15050; Tdark.
DR   PRO; PR:O15050; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; O15050; protein.
DR   Bgee; ENSG00000168016; Expressed in right hemisphere of cerebellum and 122 other tissues.
DR   ExpressionAtlas; O15050; baseline and differential.
DR   Genevisible; O15050; HS.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039904; TRANK1.
DR   PANTHER; PTHR21529; PTHR21529; 1.
DR   SMART; SM00248; ANK; 4.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Coiled coil; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..2925
FT                   /note="TPR and ankyrin repeat-containing protein 1"
FT                   /id="PRO_0000348238"
FT   REPEAT          15..48
FT                   /note="TPR 1"
FT   REPEAT          50..82
FT                   /note="TPR 2"
FT   REPEAT          168..198
FT                   /note="ANK 1"
FT   REPEAT          203..232
FT                   /note="ANK 2"
FT   REPEAT          240..276
FT                   /note="ANK 3"
FT   REPEAT          463..492
FT                   /note="ANK 4"
FT   REPEAT          497..518
FT                   /note="ANK 5"
FT   REPEAT          546..575
FT                   /note="ANK 6"
FT   REPEAT          1699..1732
FT                   /note="TPR 3"
FT   REPEAT          1793..1826
FT                   /note="TPR 4"
FT   REGION          612..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          706..741
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1077..1103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          2301..2330
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        626..645
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1083..1103
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         153
FT                   /note="P -> L (in dbSNP:rs17201603)"
FT                   /id="VAR_061021"
FT   VARIANT         703
FT                   /note="P -> L (in dbSNP:rs17201603)"
FT                   /id="VAR_046117"
FT   VARIANT         1090
FT                   /note="E -> G (in dbSNP:rs11712950)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:9205841"
FT                   /id="VAR_046118"
FT   CONFLICT        1286
FT                   /note="I -> V (in Ref. 4; BAC04838)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2925 AA;  336221 MW;  DE9E997035B98D1D CRC64;
     MWDPRAARVP PRDLAVLLCN KSNAFFSLGK WNEAFVAAKE CLQWDPTYVK GYYRAGYSLL
     RLHQPYEAAR MFFEGLRLVQ RSQDQAPVAD FLVGVFTTMS SDSIVLQSFL PCFDHIFTTG
     FPTEVWQSVI EKLAKKGLWH SFLLLSAKKD RLPRNIHVPE LSLKSLFEKY VFIGLYEKME
     QVPKLVQWLI SIGASVETIG PYPLHALMRL CIQARENHLF RWLMDHKPEW KGRINQKDGD
     GCTVLHVVAA HSPGYLVKRQ TEDVQMLLRF GADPTLLDRQ SRSVVDVLKR NKNFKAIEKI
     NSHLEKLATC SKDLSGFSNG DGPTSENDIF RKVLEQLVKY MNSGNRLLHK NFLKQEVVQR
     FLRLLSTLQE IPPDLVCDIN QDCATTVFKF LLEKQRWPEV LLLLTRKVSG EPPLGDCLIK
     DCNFSDLDIC TIIPHLSTWD QRKKQLLGCL IDSGALPDGL QESQERPVVT CLKHEDFELA
     FLLLTKGADP RAISLTEGDT PLHAALHIFL EIKADIGFSF LSHLLDLFWS NPTEFDYLNP
     NVQDSNGNTL MHILFQKGML KRVKKLLDLL VKFDINFNLK NKEGKDARHR IKKNDSLLLA
     WNKALMENRR RSRQDSAAHL GKLSKSTAPG HTSQLKSQGS FKSVPCGATA RTLPEGSAVP
     DSWETLPGTQ VTRKEPGALR PCSLRDCLMQ DITVLIQQVE VDPSFPEDCL QSSEPLEAGA
     GKEGKKDDKP TLGAGAPDCS EVGEGHAQVG LGALQLVPDD NRGKEGNDDQ DDWSTQEIEA
     CLQDFDNMTW EIECTSEMLK KLSSKVMTKV IKKKIILAIQ QLGNGEWTQG LQKRLKHLKG
     SIQLFEAKLD KGARMLWELA IDFSPRCSEN PEKIIATEQN TCAMEKSGRI YTEIIRIWDI
     VLDHCKLADS IKAICNAYNR GLSCVLRKKL KGINKGQVSA NMKIQKRIPR CYVEDTEAEK
     GREHVNPEYF PPASAVETEY NIMKFHSFST NMAFNILNDT TATVEYPFRV GELEYAVIDL
     NPRPLEPIIL IGRSGTGKTT CCLYRLWKKF HVYWEKAEQA GSPLLAKQVW LKRRLEVEPG
     KESPGGEEEE EEEDEEEEDS IEVETVESID EQEYEACAGG AGVEPAGDGQ AAEVCAPEHP
     HQLEHLHQIF VTKNHVLCQE VQRNFIELSK STKATSHYKP LDPNIHKLQD LRDENFPLFV
     TSKQLLLLLD ASLPKPFFLR NEDGSLKRTI IGWSAQEEST IPSWQEDEEE AEVDGDYSEE
     DKAVEMRTGD SDPRVYVTFE VFKNEIWPKM TKGRTAYNPA LIWKEIKSFL KGSFEALSCP
     HGRLTEEVYK KLGRKRCPNF KEDRSEIYSL FSLYQQIRSQ KGYFDEEDVL YNISRRLSKL
     RVLPWSIHEL YGDEIQDFTQ AELALLMKCI NDPNSMFLTG DTAQSIMKGV AFRFSDLRSL
     FHYASRNTID KQCAVRKPKK IHQLYQNYRS HSGILNLASG VVDLLQFYFP ESFDRLPRDS
     GLFDGPKPTV LESCSVSDLA ILLRGNKRKT QPIEFGAHQV ILVANETAKE KIPEELGLAL
     VLTIYEAKGL EFDDVLLYNF FTDSEAYKEW KIISSFTPTS TDSREENRPL VEVPLDKPGS
     SQGRSLMVNP EMYKLLNGEL KQLYTAITRA RVNLWIFDEN REKRAPAFKY FIRRDFVQVV
     KTDENKDFDD SMFVKTSTPA EWIAQGDYYA KHQCWKVAAK CYQKGGAFEK EKLALAHDTA
     LSMKSKKVSP KEKQLEYLEL AKTYLECKEP TLSLKCLSYA KEFQLSAQLC ERLGKIRDAA
     YFYKRSQCYK DAFRCFEQIQ EFDLALKMYC QEELFEEAAI AVEKYEEMLK TKTLPISKLS
     YSASQFYLEA AAKYLSANKM KEMMAVLSKL DIEDQLVFLK SRKRLAEAAD LLNREGRREE
     AALLMKQHGC LLEAARLTAD KDFQASCLLG AARLNVARDS DIEHTKDILR EALDICYQTG
     QLSGIAEAHF LQGVILRDFQ KLRDAFFKFD TLNHSAGVVE ALYEAASQCE AEPEKILGLA
     PGGLEILLSL VRALKRVTNN AEKEMVKSCF EFFGISQVDA KYCQIAQNDP GPILRIIFDL
     DLNLREKKTK DHFLIMTDQV KLALNKHLLG RLCQITRSLL GKTYRGVCMR FIVGLKCEDE
     NCEHFHRPLR RCEAKCLVQS KMNLVAINGL LLEAKKVFPK ILAEELKEID YILSTDMYGL
     CKSILDVLFP KHFHQRVLSE NPMACKEILK PNYKSFRFYR FALKEYIHFL FENESARNRR
     ESTDLWLSAM QAFLLSSNYP EEFEKLLHQE EDNYNRELKA LESEKDERGR GRGSRIKGIE
     GKFGMLAPNR DDENMDKTHL CFIRLLENCI DQFYVYRNPE DYKRLFFRFM NVLIKRCKEP
     LIPSIGNTVA LLEFQFIHCG VVLARLWKNV ILCLPKSYIA LLHYWEFLFS KKDKELGDVF
     SIIQEYKPKD VTRAIQDFRF HLSYLAKVLC GYENVNFNVL LDAFSEIDYV VSGEAERTLV
     LCLVMLVNAE EILQPYCKPL LYRHFREIES RLQLMSMDCP GQVPERLLKV VKRVLVAVNV
     KSVAEALQDL LFERDEEYLM DCDWRWDPVH TKGSIVRGLY YEEVRLNRLL CLDPVDYFAE
     PECEFGQDEM DELALEDRDH VLATILSQKQ RKASIQRKLR RACLVVSLCI SWRRRVGTQM
     ERVREEAREP RAGNFKKADV DRTQCDLCGV KFTRGPENYF SPSKAFEGAA SEVAVLSRAE
     LEREECQERN SESYEQHIHL EHHQRQQVAY QKYSEFFHEK VDPAIDEGKL VVQDIEQSVW
     IHSHVGSKEH SHMLQKVQEH IKRVSDMVED LYRRKAWAGA EEAMTRLVNI LILSVRDARD
     WLMKTETRLK KEGIVQEDDY ENEVEDFGEL RPRRRSRKCG KQRKY