ID   TRNK1_MOUSE             Reviewed;        2999 AA.
AC   Q8BV79; Q5RJH5; Q6ZQD5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 3.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=TPR and ankyrin repeat-containing protein 1;
DE   AltName: Full=Lupus brain antigen 1;
GN   Name=Trank1; Synonyms=Gm187, Kiaa0342, Lba1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-914 (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 249-791 (ISOFORM 1), AND TISSUE SPECIFICITY.
RX   PubMed=9585807; DOI=10.1016/s0165-5728(97)00157-4;
RA   Moore P.M., Vo T., Carlock L.R.;
RT   "Identification and cloning of a brain autoantigen in neuro-behavioral
RT   SLE.";
RL   J. Neuroimmunol. 82:116-125(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1660-2999 (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:167-180(2003).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8BV79-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BV79-2; Sequence=VSP_035117;
CC   -!- TISSUE SPECIFICITY: Expressed only in the brain. Detected in the
CC       hippocampus, hypothalamus and cingulate gyrus.
CC       {ECO:0000269|PubMed:9585807}.
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DR   EMBL; AC126677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC113495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC086653; AAH86653.1; -; mRNA.
DR   EMBL; AK079552; BAC37682.2; -; mRNA.
DR   EMBL; AK129119; BAC97929.1; -; Transcribed_RNA.
DR   CCDS; CCDS52942.1; -. [Q8BV79-1]
DR   RefSeq; NP_001158131.1; NM_001164659.1. [Q8BV79-1]
DR   SMR; Q8BV79; -.
DR   BioGRID; 236013; 6.
DR   IntAct; Q8BV79; 2.
DR   MINT; Q8BV79; -.
DR   STRING; 10090.ENSMUSP00000077697; -.
DR   iPTMnet; Q8BV79; -.
DR   PhosphoSitePlus; Q8BV79; -.
DR   MaxQB; Q8BV79; -.
DR   PaxDb; Q8BV79; -.
DR   PeptideAtlas; Q8BV79; -.
DR   PRIDE; Q8BV79; -.
DR   ProteomicsDB; 298134; -. [Q8BV79-1]
DR   ProteomicsDB; 298135; -. [Q8BV79-2]
DR   Antibodypedia; 51967; 13 antibodies from 8 providers.
DR   Ensembl; ENSMUST00000078626; ENSMUSP00000077697; ENSMUSG00000062296. [Q8BV79-1]
DR   GeneID; 320429; -.
DR   KEGG; mmu:320429; -.
DR   UCSC; uc009rvt.2; mouse. [Q8BV79-1]
DR   UCSC; uc009rvu.1; mouse. [Q8BV79-2]
DR   CTD; 9881; -.
DR   MGI; MGI:1341834; Trank1.
DR   VEuPathDB; HostDB:ENSMUSG00000062296; -.
DR   eggNOG; ENOG502QQZC; Eukaryota.
DR   GeneTree; ENSGT00940000153370; -.
DR   HOGENOM; CLU_227614_0_0_1; -.
DR   InParanoid; Q8BV79; -.
DR   OMA; EYSIMKF; -.
DR   OrthoDB; 5008at2759; -.
DR   PhylomeDB; Q8BV79; -.
DR   TreeFam; TF335821; -.
DR   BioGRID-ORCS; 320429; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Trank1; mouse.
DR   PRO; PR:Q8BV79; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q8BV79; protein.
DR   Bgee; ENSMUSG00000062296; Expressed in superior frontal gyrus and 115 other tissues.
DR   ExpressionAtlas; Q8BV79; baseline and differential.
DR   Genevisible; Q8BV79; MM.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR039904; TRANK1.
DR   PANTHER; PTHR21529; PTHR21529; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ANK repeat; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..2999
FT                   /note="TPR and ankyrin repeat-containing protein 1"
FT                   /id="PRO_0000348239"
FT   REPEAT          144..177
FT                   /note="TPR 1"
FT   REPEAT          179..211
FT                   /note="TPR 2"
FT   REPEAT          297..327
FT                   /note="ANK 1"
FT   REPEAT          328..361
FT                   /note="ANK 2"
FT   REPEAT          369..405
FT                   /note="ANK 3"
FT   REPEAT          538..567
FT                   /note="ANK 4"
FT   REPEAT          572..593
FT                   /note="ANK 5"
FT   REPEAT          621..654
FT                   /note="ANK 6"
FT   REPEAT          1772..1805
FT                   /note="TPR 3"
FT   REPEAT          1866..1899
FT                   /note="TPR 4"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          684..722
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          773..831
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1151..1211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1318..1344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        701..722
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1151..1181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..1699
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035117"
FT   CONFLICT        1849..1851
FT                   /note="Missing (in Ref. 5; BAC97929)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2999 AA;  343320 MW;  4B1EF2C864AC66D3 CRC64;
     MASTTAGRRW PPRRRSSRRG PTPRSRAPGA KLSAPEAGPP RRGPLPRGGA GRDTLLGAKA
     TPSSPAARRY VTALGPPQPR GSTDSACAAL PQPVPHEPRE AAFRLAPASE RGASVSPARI
     PRRRRRVPAM WDPRAARTPP RELAMLLCNK SNAFYNLGKW NEAFLAAKEC LQWDPTYVKG
     YYRAGYSLLH LLQPYEAARM FFEGLRLLQR SPDQLQVPDF LVGIFTTMSS DSIVLQSFLP
     CFDHIFTTGF STEVWQYVIQ KLAKKGLWHS FLLLSAKKDR LPSNIHVSEL SLQSLFEKYV
     FIGFYEKLEQ VPKLVQWLVS IGANIETIGP NPLHALMRLC IQARESQLFR WVMDQKPEWK
     EHINHRDDAG CTVLHVAAAH FPGYTSRRQT EDVQMLLSFG ADPTLLDGHA RTVVDVLKRN
     KNFRAIDKIN SHLEKLASSS KGLSEIPAGL VCDVNRDCAT TFIKFLLERQ KWPEVLLLLT
     RKVSGQPQLR NGVIKDCDLS DLDICTVIPH LSSWDQRKTQ LLSRLIDSGA LPEGLQDSQD
     RPLLMCLRHE DFDLAFLLLT KGADPRSVSL VEGDTPLHAA LHIFLDINAD IGFNFLSHLL
     DLFLSNPTEF YYLNPNVQDS NGNTLMHLLF QKGMLKRTKK LIDLLVKFDI NFNLKNKAGK
     GVRHRIKKND ALLLAWNKAL TESRRKNRQD PAAHLGRLSR SSAPGHTSQL KSQTSFKSLP
     CGTADTTLSK GLTESLPDVQ VSRQEPEAVR TRSLRDRLVQ DITVLIQQVE LGMPLPEDSP
     QRDSPKVAAG TEGKKDKLQR TQRMGSSGCS GNNPVASEAG DGAQAGPGAS QLVPVGNRLG
     VASDNQENWT MQEIQACLQD FDNMTWEIEC TSEMLKKLSS KVMTKVIKKK IILAIQQLGN
     GEWTQGLQKR LKHSKGNIQL FEAKLDKGAR MLWELAIDFS ARCSENSEKI IGTERNTYSL
     EKSGRVYTEI IRIWDIVLDH CKLSDSIMAI CSAYTRGLSC VLRKKLKGIN KGQVSANMKI
     QKRIPRCYVE DTEAEKSLEQ VDPEYFPPAS AVETEYSIMK FHSFSTNMAL NILNDMTATV
     EYPFRVGELE YAVIDLNPKP LEPIILIGRS GTGKTTCCLY RLWKKFHVYW EKAEQAGSPL
     LSKQILPKRR LEVEPGKEGP GREEEEHEEE EGSIKVETVD GIDEEQESEA CAGGATVEPA
     GDSQGAEGCV PDHPHQLEHL HQIFVTKNHV LCQEVQRNFI ELSKSTKATS HYKPLDPNVH
     KLQDLRDENF PLFVTSKQLL LLLDASLPKP FFLRNEDGSL KRTIVGWSTQ EEFSIPSWEE
     DDEEVEADGN YNEEEKATET QTGDSDPRVY VTFEVFTNEI WPKMIKGRSS YNPALIWKEI
     KSFLKGSFEA LSCPHGRLTE EAYKKLGRKR SPNFKEDRSE IYSLFCLYQQ IRSQKGYFDE
     EDVLYNLSWR LSKLRVLPWS IHELYGDEIQ DFTQAELALL MKCINDPNAM FLTGDTAQSI
     MKGVAFRFSD LLSLFHYASR STVDKQCAVR KPKRIHQLYQ NYRSHSGILN LASGVVDLLQ
     FYFPESFDRL PRDSGLFDGP KPTLLDSCSV SDLAILLRGN KRKTQPIEFG AHQVILVANE
     KAKEKIPEEL GLALVLTVYE AKGLEFDDVL LYNFFTDSEA YKEWKIISSF TPSSDSREEK
     WPLVDVPLER SSPSQARSLM VNPEMYKLLN GELKQLYTAI TRARVNLWIF DENLEKRAPA
     FKYFIRRDFV QVVKTDENKD FDDSMFVKTS TPYEWIIQGD YYAKHQCWKV AAKCYQKGDA
     LEKEKLALAH YTALNMKSKK FSPKEKELQY LELAKTYLEC NEPKLSLKCL SYAKEFQLSA
     QLCERLGKIR DAAYFYKRSQ CFQDAFRCFE QIQEFDLALR MYCQEELFEE AAIAVEKYEE
     MLKNKTFPIP KLSYSASQFY LEAAAKYLSA NKSKEMMAVL SKLDVEDQLV FLKSRKCLAE
     AAELLNREGR REEAALLMKQ HGCLLEAARL TANKDFQASC LLGVARFNVA RDSDIEHTKV
     ILREALDLCY QTSQLAGIAE AQFLLGIILR DFQKLRDAFI KFDMLNHSAG MVEALYEAAS
     LCESEHQKVL ALAPGGLEVL LNLVRALKNV TNNAEKEMVK SCFEFFGIFQ VDAKYCQIAQ
     NDPGPILRII LDLDLTLSEK KTKDHFLIVT DQVKLALNKH LLGRLCQITQ ILLGKAYPGI
     CMRFIVGLKC EDEQCEDFHR PLRRCEAKCM VQSKMHLVAI NGLLLEAKKV FPNVLAEDLE
     EMDYILSPDT YGLCKSFLNL LFPRHFHQRV LSENPMACKD ILKPNYKSFR SFRCALKEYI
     HDLFQKESAH SRRESTDLWL SAMQAFLLSS SYPEDFEKLL RQEEDSYNRE LKVLESDRED
     RGRGRGSRVR GIEGKFGMLV PNREDENVEK SYLCFIRLLE SSMDQLYVRR NPGDYKRLFF
     RFMNVLIKRC KAPLVPSIIN TVVLLELQFV HCGVVLTRLW KNAVLCLPKS YIALLHFWEF
     LYGKKDRESG EVFSIIQEYK PKDVTRAIRD FRFHLSYLVK VLCGYENMNF NVLLDSFSEI
     DYVISGEAER TLVLCLVMLV NAEEVLQPFC KPLLFRHFRE IQTRLQLMSM DWPGQVPKRL
     LKVVQRVLVA ASVKSVAEAL QDLLFERDEE YLVDCHWRWD SVHTKGTVVR GLCHEEVRLN
     RLLCTGPMDQ FADSEWDFGE DETHELDELA QEDRDNFLAA ILSQKQRKAL IQRKLRRVCL
     VVSLCIRWRR WVQTEHSRED REVRPGNFKR ADVDRTQCDL CGVKFTRSPE SYFSPGKAFE
     GTATEAVLIS RAELEGRECR ERISESYEQH IRLEGHRRQQ AAYQKYLDFF HEKVDPIIEE
     GKVVVQGIEQ SVWIRSHLGS KEQSHMLQRK VQEHIRRVSD LVEELYRRKA WAEAEEVMTQ
     QVKILTLSVK NAQEWLKKTE LRLKDEGTVQ EEEYENEVED FGELRPRRRA QKCGKQRKH