TRNP1_HUMAN
ID TRNP1_HUMAN Reviewed; 227 AA.
AC Q6NT89;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=TMF-regulated nuclear protein 1;
GN Name=TRNP1; Synonyms=C1orf225, TRNP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-27.
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=23622239; DOI=10.1016/j.cell.2013.03.027;
RA Stahl R., Walcher T., De Juan Romero C., Pilz G.A., Cappello S., Irmler M.,
RA Sanz-Aquela J.M., Beckers J., Blum R., Borrell V., Goetz M.;
RT "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by
RT control of radial glial fate.";
RL Cell 153:535-549(2013).
CC -!- FUNCTION: DNA-binding factor that regulates the expression of a subset
CC of genes and plays a key role in tangential, radial, and lateral
CC expansion of the brain neocortex. Regulates neural stem cells
CC proliferation and the production of intermediate neural progenitors and
CC basal radial glial cells affecting the process of cerebral cortex
CC gyrification. May control the proliferation rate of cells by regulating
CC their progression through key cell-cycle transition points (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TMF1; may regulate TRNP1 proteasomal
CC degradation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expression is detected in the ventricular zone and
CC neuronal layers of the developing cerebral cortex at 12, 18 and 21
CC gestation weeks. Differences in regional expression seem to correlate
CC with the process of gyrification of the cortex. Highly expressed in
CC germinal layers of the precentral and parahippocampal gyri, that
CC exhibit little radial expansion and folding, and weakly expressed in
CC germinal layers of the occipital and temporal lobes, that undergo
CC greater expansion and folding. {ECO:0000269|PubMed:23622239}.
CC -!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
CC {ECO:0000250}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=the geometry of intelligence
CC - Issue 152 of August 2013;
CC URL="https://web.expasy.org/spotlight/back_issues/152/";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL356390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069216; AAH69216.1; -; mRNA.
DR CCDS; CCDS41289.1; -.
DR RefSeq; NP_001013664.1; NM_001013642.2.
DR RefSeq; XP_005245924.1; XM_005245867.3.
DR AlphaFoldDB; Q6NT89; -.
DR BioGRID; 132770; 5.
DR IntAct; Q6NT89; 1.
DR STRING; 9606.ENSP00000429216; -.
DR iPTMnet; Q6NT89; -.
DR PhosphoSitePlus; Q6NT89; -.
DR BioMuta; TRNP1; -.
DR DMDM; 224471860; -.
DR MassIVE; Q6NT89; -.
DR PaxDb; Q6NT89; -.
DR PeptideAtlas; Q6NT89; -.
DR PRIDE; Q6NT89; -.
DR ProteomicsDB; 66667; -.
DR Antibodypedia; 68540; 39 antibodies from 9 providers.
DR DNASU; 388610; -.
DR Ensembl; ENST00000522111.3; ENSP00000429216.2; ENSG00000253368.4.
DR GeneID; 388610; -.
DR KEGG; hsa:388610; -.
DR MANE-Select; ENST00000522111.3; ENSP00000429216.2; NM_001013642.3; NP_001013664.2.
DR UCSC; uc001bnj.5; human.
DR CTD; 388610; -.
DR DisGeNET; 388610; -.
DR GeneCards; TRNP1; -.
DR HGNC; HGNC:34348; TRNP1.
DR HPA; ENSG00000253368; Tissue enhanced (esophagus, retina, stomach).
DR neXtProt; NX_Q6NT89; -.
DR OpenTargets; ENSG00000253368; -.
DR PharmGKB; PA164727311; -.
DR VEuPathDB; HostDB:ENSG00000253368; -.
DR eggNOG; ENOG502S7AN; Eukaryota.
DR GeneTree; ENSGT00390000017418; -.
DR HOGENOM; CLU_106336_0_0_1; -.
DR InParanoid; Q6NT89; -.
DR OMA; NTETHNE; -.
DR OrthoDB; 1585515at2759; -.
DR PhylomeDB; Q6NT89; -.
DR TreeFam; TF338814; -.
DR PathwayCommons; Q6NT89; -.
DR SignaLink; Q6NT89; -.
DR BioGRID-ORCS; 388610; 70 hits in 1074 CRISPR screens.
DR GenomeRNAi; 388610; -.
DR Pharos; Q6NT89; Tdark.
DR PRO; PR:Q6NT89; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6NT89; protein.
DR Bgee; ENSG00000253368; Expressed in cardiac muscle of right atrium and 171 other tissues.
DR ExpressionAtlas; Q6NT89; baseline and differential.
DR Genevisible; Q6NT89; HS.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0021696; P:cerebellar cortex morphogenesis; ISS:UniProtKB.
DR GO; GO:0061351; P:neural precursor cell proliferation; ISS:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR InterPro; IPR040266; TRNP1.
DR PANTHER; PTHR40714; PTHR40714; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Developmental protein; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..227
FT /note="TMF-regulated nuclear protein 1"
FT /id="PRO_0000336088"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..53
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 27
FT /note="W -> R (in dbSNP:rs6689941)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_043545"
SQ SEQUENCE 227 AA; 23482 MW; 01FBA6DC86CCD7CA CRC64;
MPGCRISACG PGAQEGTAEQ RSPPPPWDPM PSSQPPPPTP TLTPTPTPGQ SPPLPDAAGA
SAGAAEDQEL QRWRQGASGI AGLAGPGGGS GAAAGAGGRA LELAEARRRL LEVEGRRRLV
SELESRVLQL HRVFLAAELR LAHRAESLSR LSGGVAQAEL YLAAHGSRLK KGPRRGRRGR
PPALLASALG LGGCVPWGAG RLRRGHGPEP DSPFRRSPPR GPASPQR
