TRNP1_MOUSE
ID TRNP1_MOUSE Reviewed; 223 AA.
AC Q80ZI1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=TMF-regulated nuclear protein 1;
GN Name=Trnp1; Synonyms=Trnp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP FUNCTION, INTERACTION WITH TMF1, UBIQUITINATION, AND TISSUE SPECIFICITY.
RX PubMed=16792503; DOI=10.1089/dna.2006.25.331;
RA Volpe M., Shpungin S., Barbi C., Abrham G., Malovani H., Wides R., Nir U.;
RT "TRNP: a conserved mammalian gene encoding a nuclear protein that
RT accelerates cell-cycle progression.";
RL DNA Cell Biol. 25:331-339(2006).
RN [3]
RP FUNCTION IN CEREBRAL CORTEX EXPANSION, DNA-BINDING, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=23622239; DOI=10.1016/j.cell.2013.03.027;
RA Stahl R., Walcher T., De Juan Romero C., Pilz G.A., Cappello S., Irmler M.,
RA Sanz-Aquela J.M., Beckers J., Blum R., Borrell V., Goetz M.;
RT "Trnp1 regulates expansion and folding of the mammalian cerebral cortex by
RT control of radial glial fate.";
RL Cell 153:535-549(2013).
CC -!- FUNCTION: DNA-binding factor that regulates the expression of a subset
CC of genes and plays a key role in tangential, radial, and lateral
CC expansion of the brain neocortex. Regulates neural stem cells
CC proliferation and the production of intermediate neural progenitors and
CC basal radial glial cells affecting the process of cerebral cortex
CC gyrification. May control the proliferation rate of cells by regulating
CC their progression through key cell-cycle transition points.
CC {ECO:0000269|PubMed:16792503, ECO:0000269|PubMed:23622239}.
CC -!- SUBUNIT: Interacts with TMF1; may regulate TRNP1 proteasomal
CC degradation. {ECO:0000269|PubMed:16792503}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23622239}.
CC -!- TISSUE SPECIFICITY: Expressed in brain and kidney (at protein level).
CC Also detected in spleen and intestine. {ECO:0000269|PubMed:16792503,
CC ECO:0000269|PubMed:23622239}.
CC -!- DEVELOPMENTAL STAGE: Expression is highly restricted to the phase of
CC neurogenesis with high levels in all cells in the ventricular zone (VZ)
CC at 10 dpc. Expression disappears at the end of neurogenesis (18 dpc).
CC However, it remains present in a specific adult neurogenic region with
CC the highest amplification and neuronal output, the subependymal zone of
CC the lateral ventricle from where newborn neurons migrate to the
CC olfactory bulb (at protein level). {ECO:0000269|PubMed:23622239}.
CC -!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
CC {ECO:0000269|PubMed:16792503}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=the geometry of intelligence
CC - Issue 152 of August 2013;
CC URL="https://web.expasy.org/spotlight/back_issues/152/";
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DR EMBL; BC049168; AAH49168.1; -; mRNA.
DR CCDS; CCDS38904.1; -.
DR RefSeq; NP_001074625.1; NM_001081156.2.
DR RefSeq; XP_006539218.1; XM_006539155.2.
DR AlphaFoldDB; Q80ZI1; -.
DR SMR; Q80ZI1; -.
DR IntAct; Q80ZI1; 1.
DR STRING; 10090.ENSMUSP00000129613; -.
DR iPTMnet; Q80ZI1; -.
DR PhosphoSitePlus; Q80ZI1; -.
DR PaxDb; Q80ZI1; -.
DR PRIDE; Q80ZI1; -.
DR ProteomicsDB; 300124; -.
DR Antibodypedia; 68540; 39 antibodies from 9 providers.
DR Ensembl; ENSMUST00000125541; ENSMUSP00000129613; ENSMUSG00000056596.
DR GeneID; 69539; -.
DR KEGG; mmu:69539; -.
DR UCSC; uc008vcu.1; mouse.
DR CTD; 388610; -.
DR MGI; MGI:1916789; Trnp1.
DR VEuPathDB; HostDB:ENSMUSG00000056596; -.
DR eggNOG; ENOG502S7AN; Eukaryota.
DR GeneTree; ENSGT00390000017418; -.
DR HOGENOM; CLU_106336_0_0_1; -.
DR InParanoid; Q80ZI1; -.
DR OMA; NTETHNE; -.
DR OrthoDB; 1585515at2759; -.
DR PhylomeDB; Q80ZI1; -.
DR TreeFam; TF338814; -.
DR BioGRID-ORCS; 69539; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Trnp1; mouse.
DR PRO; PR:Q80ZI1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80ZI1; protein.
DR Bgee; ENSMUSG00000056596; Expressed in medial dorsal nucleus of thalamus and 193 other tissues.
DR Genevisible; Q80ZI1; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0021696; P:cerebellar cortex morphogenesis; IMP:UniProtKB.
DR GO; GO:0061351; P:neural precursor cell proliferation; IMP:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; IMP:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:UniProtKB.
DR InterPro; IPR040266; TRNP1.
DR PANTHER; PTHR40714; PTHR40714; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Developmental protein; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..223
FT /note="TMF-regulated nuclear protein 1"
FT /id="PRO_0000336089"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..54
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..223
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 223 AA; 23086 MW; F7BF3F085B025DDE CRC64;
MPGCRISACG PGAQEGTAEP GSPPPPPREP LPSLQPPSPS PTSTPTPTKS PPLPEAAETP
VEGQELQRWR QGASGGSGGA GPAGIAGAAA GAGGRALELA EARRRLLEVE GRRRLVSELE
SRVLQLHRVF LAAELRLAHR AESLSRLSGG VAQAELYLAA HGSRLKKGAR RGRRGRPPAL
LASALGLGSC VPWGAGRLRR GQGPEPDSPF RRSPPRGPAS PQR
