TROAP_MOUSE
ID TROAP_MOUSE Reviewed; 668 AA.
AC B7ZNG4; Q497S4; Q8BWP3;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Tastin {ECO:0000250|UniProtKB:Q12815};
DE AltName: Full=Troap protein {ECO:0000312|EMBL:AAI45228.1};
DE AltName: Full=Trophinin-assisting protein {ECO:0000250|UniProtKB:Q12815};
DE AltName: Full=Trophinin-associated protein {ECO:0000250|UniProtKB:Q12815};
GN Name=Troap {ECO:0000312|EMBL:AAI45228.1, ECO:0000312|MGI:MGI:1925983};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAC34223.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC34223.1};
RC TISSUE=Liver tumor {ECO:0000312|EMBL:BAC34223.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|EMBL:EDL04145.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAI45228.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAI00406.1};
RC TISSUE=Egg {ECO:0000312|EMBL:AAI00406.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could be involved with bystin and trophinin in a cell
CC adhesion molecule complex that mediates an initial attachment of the
CC blastocyst to uterine epithelial cells at the time of the embryo
CC implantation. {ECO:0000250|UniProtKB:Q12815}.
CC -!- SUBUNIT: Directly binds bystin, and indirectly trophinin.
CC {ECO:0000250|UniProtKB:Q12815}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q12815}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI00406.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK050381; BAC34223.1; -; mRNA.
DR EMBL; CH466550; EDL04145.1; -; Genomic_DNA.
DR EMBL; BC100405; AAI00406.1; ALT_INIT; mRNA.
DR EMBL; BC145227; AAI45228.1; -; mRNA.
DR CCDS; CCDS57008.1; -.
DR RefSeq; NP_001155978.1; NM_001162506.1.
DR RefSeq; NP_084435.1; NM_030159.1.
DR AlphaFoldDB; B7ZNG4; -.
DR BioGRID; 219599; 5.
DR STRING; 10090.ENSMUSP00000035389; -.
DR iPTMnet; B7ZNG4; -.
DR PhosphoSitePlus; B7ZNG4; -.
DR EPD; B7ZNG4; -.
DR MaxQB; B7ZNG4; -.
DR PaxDb; B7ZNG4; -.
DR PRIDE; B7ZNG4; -.
DR ProteomicsDB; 258984; -.
DR Antibodypedia; 25932; 79 antibodies from 20 providers.
DR Ensembl; ENSMUST00000039665; ENSMUSP00000035389; ENSMUSG00000032783.
DR Ensembl; ENSMUST00000230054; ENSMUSP00000155404; ENSMUSG00000032783.
DR GeneID; 78733; -.
DR KEGG; mmu:78733; -.
DR UCSC; uc007xor.2; mouse.
DR CTD; 10024; -.
DR MGI; MGI:1925983; Troap.
DR VEuPathDB; HostDB:ENSMUSG00000032783; -.
DR eggNOG; ENOG502S991; Eukaryota.
DR GeneTree; ENSGT00390000012132; -.
DR HOGENOM; CLU_020167_0_0_1; -.
DR InParanoid; B7ZNG4; -.
DR OMA; FHPSAHP; -.
DR OrthoDB; 549706at2759; -.
DR PhylomeDB; B7ZNG4; -.
DR TreeFam; TF338049; -.
DR BioGRID-ORCS; 78733; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Troap; mouse.
DR PRO; PR:B7ZNG4; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; B7ZNG4; protein.
DR Bgee; ENSMUSG00000032783; Expressed in humerus cartilage element and 73 other tissues.
DR Genevisible; B7ZNG4; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR InterPro; IPR026133; Tastin.
DR PANTHER; PTHR15289; PTHR15289; 2.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..668
FT /note="Tastin"
FT /id="PRO_0000394294"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q12815"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q12815"
FT MOD_RES 169
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q12815"
FT MOD_RES 306
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q12815"
FT MOD_RES 324
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q12815"
FT MOD_RES 338
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q12815"
FT CONFLICT 95
FT /note="K -> E (in Ref. 1; BAC34223)"
FT /evidence="ECO:0000305"
FT CONFLICT 464
FT /note="P -> S (in Ref. 1; BAC34223)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 668 AA; 71959 MW; 0C17E01F944DCB59 CRC64;
MTTLQTNKDP HLRGVSPNPS KIPVLSQRCQ DFSSVKSRSL DQENQDPRTP AQKPPRSTQR
QRPLTDTAGL RSKTLHQTEK SPSLKTLRNP LEELKPSSGG SNVGLVTHPQ TEAIGAIEFV
ADPAALATIL SGEGVKSCPQ GYRSSLAQRV LVRERKGGTT QRGQSARSSA YLAPRIPTHQ
VGPARASCFS RLEGPGLRDH TLSPPRLEAL NPPPGSSHSS TRPSLQELRR ETCGGGRDGD
CTDRRTSASQ ASRLLLKTPV QPASLPLRGE QEAVPHSDDG GGRHHLGLAQ RIPLKESLTN
TRSTYSSMKR FAIRRKAQFT PLRSLPKVQQ AQWLSGLSPH SSPEEPALPW RQIAMKLFDQ
ESRITLQKEP RKPSVASTSG PRPKRTPSHQ ELRIQRINIL QQLLQQEVEG LAMGDGAPLN
GGSAFDMTEL KLPTAEISRT LTASEHNSGA ALVGLSQHSG ATEPLLSEEC EEPQAYPEET
KAAQPCSTTE LKPPVPHRAE PELPEPCLPA LSGPPLPSCR GQAEPPMACP RTEPGASAAC
ALEAGTPESS TQPCCNQGPP ATASLTFSSQ SPVCASPSIH SLYPTGYSGP SSLAPRTLAL
RQRLRACLDT IHSFQEAHLD DECAFYTSRA PPPGPTRVFT NPVVTTLEWQ DALRFVPIGP
VVPQDSPS
