TROB_TREPA
ID TROB_TREPA Reviewed; 266 AA.
AC P96117;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Zinc transport system ATP-binding protein TroB;
GN Name=troB; OrderedLocusNames=TP_0164;
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX NCBI_TaxID=243276;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=9332349; DOI=10.1016/s0378-1119(97)00234-5;
RA Hardham J.M., Stamm L.V., Porcella S.F., Frye J.G., Barnes N.Y.,
RA Howell J.K., Mueller S.L., Radolf J.D., Weinstock G.M., Norris S.J.;
RT "Identification and transcriptional analysis of a Treponema pallidum operon
RT encoding a putative ABC transport system, an iron-activated repressor
RT protein homolog, and a glycolytic pathway enzyme homolog.";
RL Gene 197:47-64(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- FUNCTION: Part of an ATP-driven transport system TroABCD for zinc.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U55214; AAC45726.1; -; Genomic_DNA.
DR EMBL; AE000520; AAC65154.1; -; Genomic_DNA.
DR PIR; A71357; A71357.
DR RefSeq; WP_010881611.1; NC_021490.2.
DR AlphaFoldDB; P96117; -.
DR SMR; P96117; -.
DR IntAct; P96117; 4.
DR STRING; 243276.TPANIC_0164; -.
DR TCDB; 3.A.1.15.8; the atp-binding cassette (abc) superfamily.
DR PRIDE; P96117; -.
DR EnsemblBacteria; AAC65154; AAC65154; TP_0164.
DR KEGG; tpa:TP_0164; -.
DR eggNOG; COG1121; Bacteria.
DR HOGENOM; CLU_000604_1_11_12; -.
DR OMA; SVWDVVM; -.
DR OrthoDB; 1721927at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Ion transport; Nucleotide-binding; Reference proteome;
KW Transport; Zinc; Zinc transport.
FT CHAIN 1..266
FT /note="Zinc transport system ATP-binding protein TroB"
FT /id="PRO_0000093025"
FT DOMAIN 11..243
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 43..50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 266 AA; 29360 MW; A7EB2DEDC4CF85B6 CRC64;
MAEISATAYA VQVDDLTLAY RQKPVLWDVD VRIPEGVIEA IIGPNGAGKS TLLKAIMGLL
PLASGEVRVF GRPFSKERRR VAYVPQRSAV DWDFPTTVFD VVLMGSYGSL GWILRPGKRE
KARAREAIEE VGMGAFLDRQ ISELSGGQQQ RVFLARALVQ DADLYFMDEP FQGVDAATEQ
AIVTLLKTLK GRGKTLLVVH HDLQTVAEYF DRVLLLNVRV IAEGAVVSAF TEEYVQRAYG
GRISSTLFPR GNKEDVHDAR AHASVL
