ID   TROC_TREPA              Reviewed;         298 AA.
AC   P96118;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Zinc transport system membrane protein TroC;
GN   Name=troC; OrderedLocusNames=TP_0165;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9332349; DOI=10.1016/s0378-1119(97)00234-5;
RA   Hardham J.M., Stamm L.V., Porcella S.F., Frye J.G., Barnes N.Y.,
RA   Howell J.K., Mueller S.L., Radolf J.D., Weinstock G.M., Norris S.J.;
RT   "Identification and transcriptional analysis of a Treponema pallidum operon
RT   encoding a putative ABC transport system, an iron-activated repressor
RT   protein homolog, and a glycolytic pathway enzyme homolog.";
RL   Gene 197:47-64(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Part of an ATP-driven transport system TroABCD for zinc.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC-3 integral membrane protein family.
CC       {ECO:0000305}.
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DR   EMBL; U55214; AAC45727.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65155.1; -; Genomic_DNA.
DR   PIR; B71357; B71357.
DR   RefSeq; WP_010881612.1; NC_021490.2.
DR   AlphaFoldDB; P96118; -.
DR   SMR; P96118; -.
DR   IntAct; P96118; 3.
DR   STRING; 243276.TPANIC_0165; -.
DR   TCDB; 3.A.1.15.8; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAC65155; AAC65155; TP_0165.
DR   GeneID; 57878707; -.
DR   KEGG; tpa:TP_0165; -.
DR   eggNOG; COG1108; Bacteria.
DR   HOGENOM; CLU_028808_0_0_12; -.
DR   OMA; GAWLSYY; -.
DR   OrthoDB; 1421296at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR001626; ABC_TroCD.
DR   PANTHER; PTHR30477; PTHR30477; 1.
DR   Pfam; PF00950; ABC-3; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..298
FT                   /note="Zinc transport system membrane protein TroC"
FT                   /id="PRO_0000171154"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   298 AA;  31540 MW;  E4AE590B64BCC259 CRC64;
     MHALMRLFSD YTLQNVVLGT LFLGLGSGLV GSFAVLRRQS LFGDAVSHAT LPGIVIAFLL
     TGTKSTEILL LGAALSGLVG TVVMLMVMRT TKIDTDGAQG IVLGVFLGFG FLLLTHVQKS
     PQAAKAGLNK FILGQAATIL QRDVLLIIAM EVVIGLLVLL FWKELKLSTF DRDFSAVQGF
     SPQLMEFMLT ALIVVAVVVG VQAVGVILMS ALLTAPAVAA RQWTNSLRVL CALAALFGGV
     SGVSGSVVSA QVPRLSTGPV IVLVLTGIAL VSIMLGPQRG VLYQLWRRRR VSLLQEEG