ID   TROPA_IXOSC             Reviewed;         161 AA.
AC   Q5SDL7; Q5SGK2;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Tick receptor for ospA;
GN   Name=TROSPA;
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=15537536; DOI=10.1016/j.cell.2004.10.027;
RA   Pal U., Li X., Wang T., Montgomery R.R., Ramamoorthi N., Desilva A.M.,
RA   Bao F., Yang X., Pypaert M., Pradhan D., Kantor F.S., Telford S.,
RA   Anderson J.F., Fikrig E.;
RT   "TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi.";
RL   Cell 119:457-468(2004).
CC   -!- FUNCTION: Serves as a receptor for ospA protein of B.burgdorferi, the
CC       Lyme disease agent. Required for spirochetal colonization. Essential
CC       for pathogen adherence to the vector.
CC   -!- SUBUNIT: Interacts with ospA protein from B.burgdorferi.
CC   -!- SUBCELLULAR LOCATION: Cell membrane. Note=Predominantly found in the
CC       cell membrane. May be an integral membrane or secreted. However, no
CC       clear transmembrane domain or signal sequence are predicted by sequence
CC       analysis tools.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in gut. Localizes
CC       predominantly in the intercellular spaces and luminal surface of the
CC       gut. In the gut, it localizes along tight junctions. Not expressed in
CC       salivary gland or hemolymph.
CC   -!- DEVELOPMENTAL STAGE: Expressed in larvae, nymphs and at lower level in
CC       adults.
CC   -!- INDUCTION: Increases following spirochete infestation and decreases in
CC       response to engorgement, events that are temporally linked to
CC       B.burgdorferi entry into and egress from the vector.
CC   -!- PTM: Glycosylated.
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DR   EMBL; AY189148; AAO43095.1; -; mRNA.
DR   EMBL; AY640046; AAV33389.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5SDL7; -.
DR   Proteomes; UP000001555; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome.
FT   CHAIN           1..161
FT                   /note="Tick receptor for ospA"
FT                   /id="PRO_0000065637"
FT   CONFLICT        35
FT                   /note="E -> V (in Ref. 1; AAV33389)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        38
FT                   /note="V -> E (in Ref. 1; AAV33389)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        93
FT                   /note="A -> G (in Ref. 1; AAV33389)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        96
FT                   /note="S -> L (in Ref. 1; AAV33389)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   161 AA;  16087 MW;  3E4653EB7996588E CRC64;
     MVAMEAMAAM EVMVAAMAAT ADTVASSAAS ATATEATVAM DTASLSLPLQ LSPRSLPQSS
     LSATAATVAT DTVVSSADTE VSDTEDSAAT VSATASLSML PQSSPRSLPQ SSLSATAATV
     DSVTDMADTA MDTKQFISKG NEHFFAASYL CAWADQSAAG S