ID   TROPK_TALSN             Reviewed;         551 AA.
AC   B8M9K6;
DT   07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Tropolone cluster transcription factor tropK {ECO:0000305};
DE   AltName: Full=Tropolone synthesis protein K {ECO:0000303|PubMed:24863423};
GN   Name=tropK {ECO:0000303|PubMed:24863423};
GN   Synonyms=tsR6 {ECO:0000303|PubMed:22508998}; ORFNames=TSTA_117810;
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX   PubMed=22508998; DOI=10.1073/pnas.1201469109;
RA   Davison J., al Fahad A., Cai M., Song Z., Yehia S.Y., Lazarus C.M.,
RA   Bailey A.M., Simpson T.J., Cox R.J.;
RT   "Genetic, molecular, and biochemical basis of fungal tropolone
RT   biosynthesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:7642-7647(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX   PubMed=24863423; DOI=10.1002/anie.201403450;
RA   al Fahad A., Abood A., Simpson T.J., Cox R.J.;
RT   "The biosynthesis and catabolism of the maleic anhydride moiety of
RT   stipitatonic acid.";
RL   Angew. Chem. Int. Ed. 53:7519-7523(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis tropolone class of fungal
CC       maleic anhydrides, including stipitaldehydic, stipitatonic and
CC       stipitatic acids (PubMed:22508998, PubMed:24863423).
CC       {ECO:0000305|PubMed:22508998, ECO:0000305|PubMed:24863423}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; BK008910; DAA64710.1; -; Genomic_DNA.
DR   EMBL; EQ962655; EED18009.1; -; Genomic_DNA.
DR   RefSeq; XP_002482001.1; XM_002481956.1.
DR   AlphaFoldDB; B8M9K6; -.
DR   PRIDE; B8M9K6; -.
DR   EnsemblFungi; EED18009; EED18009; TSTA_117810.
DR   GeneID; 8105839; -.
DR   VEuPathDB; FungiDB:TSTA_117810; -.
DR   eggNOG; ENOG502SH49; Eukaryota.
DR   HOGENOM; CLU_011017_3_1_1; -.
DR   PhylomeDB; B8M9K6; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..551
FT                   /note="Tropolone cluster transcription factor tropK"
FT                   /id="PRO_0000437137"
FT   DNA_BIND        25..52
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   551 AA;  63144 MW;  B14BC1117E8D9744 CRC64;
     MSVAIKMSTN TVGGQSTRQP PGSACLHCRN KKMKCDALQP RCKNCFNAGV ECIRSNNYSR
     KRSAQRDHIE GPQDRVETSD AEVYDVQPKF NPGLFNLDFH MDSFYDMDYN FLENITPESF
     PILSPLDSLP SLIPSETVEC SQPQTVIETA GILAPPLNDP INDLMHEDLD QLYLDRVHRL
     IPILHRRRYF SWTRSPNRTD AQTCLQFAMW TLATSLSTQL QHLRESFYQR TCSLLDKFTA
     QDTAAPQIEY AQACILIVNY DLMKENFRRG WTSAGRCIRV IQLMRLFEID RSKGRNDRED
     WIQREEKRRA FWMAYSLDLF ISLRGEWPLS LTGTDFVRLP ALDKDFDNSH YVEMPFLGTV
     LSGASSSVLS PWAESIVFAT IIRRITALTS ELEGLSPGSS STNVWSKIDL LRNILKSRLA
     SLSFKHQDSH FPFSDDPMET FMIMIAQSSV LYLYNTQKSF SRATESSQNI SMALQYEAQM
     AAQEIANLST SILHMSRFKI HPFTPLILAK CMEFYKSNQN LDEITQAAVK QIYELLRHIS
     KVNNIAVEYL S