TROP_HUMAN
ID TROP_HUMAN Reviewed; 1431 AA.
AC Q12816; B1AKE9; B1AKF1; F5GY27; Q96SX2; Q9NU89; Q9UPN8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 3.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Trophinin;
DE AltName: Full=MAGE-D3 antigen;
GN Name=TRO; Synonyms=KIAA1114, MAGED3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLY-738.
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:197-205(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 674-1431 (ISOFORM 1).
RX PubMed=7758945; DOI=10.1101/gad.9.10.1199;
RA Fukuda M.N., Sato T., Nakayama J., Klier G., Mikami M., Aoki D., Nozawa S.;
RT "Trophinin and tastin, a novel cell adhesion molecule complex with
RT potential involvement in embryo implantation.";
RL Genes Dev. 9:1199-1210(1995).
RN [6]
RP SEQUENCE REVISION TO 697; 736 AND 747.
RA Fukuda M., Sato T.;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP VARIANT SER-951.
RX PubMed=23092983; DOI=10.1038/tp.2012.102;
RA Nava C., Lamari F., Heron D., Mignot C., Rastetter A., Keren B., Cohen D.,
RA Faudet A., Bouteiller D., Gilleron M., Jacquette A., Whalen S., Afenjar A.,
RA Perisse D., Laurent C., Dupuits C., Gautier C., Gerard M., Huguet G.,
RA Caillet S., Leheup B., Leboyer M., Gillberg C., Delorme R., Bourgeron T.,
RA Brice A., Depienne C.;
RT "Analysis of the chromosome X exome in patients with autism spectrum
RT disorders identified novel candidate genes, including TMLHE.";
RL Transl. Psychiatry 2:E179-E179(2012).
CC -!- FUNCTION: Could be involved with bystin and tastin in a cell adhesion
CC molecule complex that mediates an initial attachment of the blastocyst
CC to uterine epithelial cells at the time of the embryo implantation.
CC Directly responsible for homophilic cell adhesion.
CC -!- SUBUNIT: Directly binds bystin, and indirectly tastin.
CC -!- INTERACTION:
CC Q12816; Q13895: BYSL; NbExp=4; IntAct=EBI-950001, EBI-358049;
CC Q12816; Q93009: USP7; NbExp=2; IntAct=EBI-950001, EBI-302474;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q12816-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q12816-2; Sequence=VSP_043513, VSP_043514;
CC Name=3;
CC IsoId=Q12816-3; Sequence=VSP_053937;
CC Name=4;
CC IsoId=Q12816-4; Sequence=VSP_053938;
CC Name=5;
CC IsoId=Q12816-5; Sequence=VSP_053938, VSP_043513, VSP_043514;
CC -!- TISSUE SPECIFICITY: Strong expression at implantation sites. Found in
CC the placenta from the sixth week of pregnancy. Was localized in the
CC cytoplasm of the syncytiotrophoblast in the chorionic villi and in
CC endometrial decidual cells at the uteroplacental interface. After week
CC 10, the level decreased and then disappeared from placental villi. Also
CC found in macrophages.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA79334.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA83066.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB029037; BAA83066.3; ALT_INIT; mRNA.
DR EMBL; AK027489; BAB55149.1; -; mRNA.
DR EMBL; AL049732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471154; EAW93200.1; -; Genomic_DNA.
DR EMBL; CH471154; EAW93205.1; -; Genomic_DNA.
DR EMBL; U04811; AAA79334.2; ALT_INIT; mRNA.
DR CCDS; CCDS43958.1; -. [Q12816-2]
DR CCDS; CCDS43959.1; -. [Q12816-1]
DR CCDS; CCDS59527.1; -. [Q12816-5]
DR CCDS; CCDS59528.1; -. [Q12816-4]
DR CCDS; CCDS59529.1; -. [Q12816-3]
DR PIR; I38488; I38488.
DR RefSeq; NP_001034794.1; NM_001039705.2. [Q12816-1]
DR RefSeq; NP_001258112.1; NM_001271183.1. [Q12816-3]
DR RefSeq; NP_057241.2; NM_016157.3. [Q12816-2]
DR RefSeq; NP_808224.1; NM_177556.2. [Q12816-2]
DR RefSeq; NP_808225.1; NM_177557.2. [Q12816-5]
DR RefSeq; XP_006724663.1; XM_006724600.2. [Q12816-1]
DR RefSeq; XP_011529110.1; XM_011530808.1. [Q12816-1]
DR RefSeq; XP_011529111.1; XM_011530809.1. [Q12816-1]
DR RefSeq; XP_011529113.1; XM_011530811.2. [Q12816-1]
DR RefSeq; XP_011529114.1; XM_011530812.1. [Q12816-1]
DR RefSeq; XP_011529115.1; XM_011530813.1. [Q12816-1]
DR RefSeq; XP_016885256.1; XM_017029767.1. [Q12816-1]
DR RefSeq; XP_016885258.1; XM_017029769.1. [Q12816-2]
DR RefSeq; XP_016885259.1; XM_017029770.1. [Q12816-2]
DR RefSeq; XP_016885260.1; XM_017029771.1. [Q12816-2]
DR AlphaFoldDB; Q12816; -.
DR BioGRID; 113067; 42.
DR IntAct; Q12816; 26.
DR MINT; Q12816; -.
DR STRING; 9606.ENSP00000173898; -.
DR iPTMnet; Q12816; -.
DR PhosphoSitePlus; Q12816; -.
DR BioMuta; TRO; -.
DR DMDM; 152031714; -.
DR EPD; Q12816; -.
DR jPOST; Q12816; -.
DR MassIVE; Q12816; -.
DR MaxQB; Q12816; -.
DR PaxDb; Q12816; -.
DR PeptideAtlas; Q12816; -.
DR PRIDE; Q12816; -.
DR ProteomicsDB; 24606; -.
DR ProteomicsDB; 3053; -.
DR ProteomicsDB; 3054; -.
DR ProteomicsDB; 58968; -. [Q12816-1]
DR ProteomicsDB; 58969; -. [Q12816-2]
DR Antibodypedia; 62228; 57 antibodies from 17 providers.
DR DNASU; 7216; -.
DR Ensembl; ENST00000173898.12; ENSP00000173898.7; ENSG00000067445.22. [Q12816-1]
DR Ensembl; ENST00000319167.12; ENSP00000318278.8; ENSG00000067445.22. [Q12816-2]
DR Ensembl; ENST00000375022.8; ENSP00000364162.4; ENSG00000067445.22. [Q12816-2]
DR Ensembl; ENST00000375041.6; ENSP00000364181.2; ENSG00000067445.22. [Q12816-4]
DR Ensembl; ENST00000399736.5; ENSP00000382641.1; ENSG00000067445.22. [Q12816-5]
DR Ensembl; ENST00000420798.6; ENSP00000405126.2; ENSG00000067445.22. [Q12816-3]
DR GeneID; 7216; -.
DR KEGG; hsa:7216; -.
DR MANE-Select; ENST00000173898.12; ENSP00000173898.7; NM_001039705.3; NP_001034794.1.
DR UCSC; uc004dtq.6; human. [Q12816-1]
DR CTD; 7216; -.
DR DisGeNET; 7216; -.
DR GeneCards; TRO; -.
DR HGNC; HGNC:12326; TRO.
DR HPA; ENSG00000067445; Tissue enhanced (skeletal).
DR MIM; 300132; gene.
DR neXtProt; NX_Q12816; -.
DR OpenTargets; ENSG00000067445; -.
DR PharmGKB; PA37002; -.
DR VEuPathDB; HostDB:ENSG00000067445; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000162763; -.
DR HOGENOM; CLU_001549_0_0_1; -.
DR InParanoid; Q12816; -.
DR OMA; EYNRIPH; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; Q12816; -.
DR TreeFam; TF352132; -.
DR PathwayCommons; Q12816; -.
DR SignaLink; Q12816; -.
DR BioGRID-ORCS; 7216; 6 hits in 695 CRISPR screens.
DR ChiTaRS; TRO; human.
DR GeneWiki; TRO_(gene); -.
DR GenomeRNAi; 7216; -.
DR Pharos; Q12816; Tbio.
DR PRO; PR:Q12816; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q12816; protein.
DR Bgee; ENSG00000067445; Expressed in adenohypophysis and 154 other tissues.
DR ExpressionAtlas; Q12816; baseline and differential.
DR Genevisible; Q12816; HS.
DR GO; GO:0031226; C:intrinsic component of plasma membrane; TAS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0007566; P:embryo implantation; TAS:ProtInc.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; TAS:ProtInc.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 1.
DR Gene3D; 1.10.10.1210; -; 1.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 1.
DR Pfam; PF01454; MAGE; 1.
DR SMART; SM01373; MAGE; 1.
DR PROSITE; PS50838; MAGE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell adhesion; Reference proteome; Repeat.
FT CHAIN 1..1431
FT /note="Trophinin"
FT /id="PRO_0000156742"
FT DOMAIN 444..642
FT /note="MAGE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REPEAT 751..760
FT /note="1"
FT REPEAT 769..778
FT /note="2"
FT REPEAT 779..786
FT /note="3; approximate"
FT REPEAT 787..796
FT /note="4"
FT REPEAT 805..814
FT /note="5"
FT REPEAT 823..833
FT /note="6; approximate"
FT REPEAT 841..850
FT /note="7"
FT REPEAT 859..870
FT /note="8; approximate"
FT REPEAT 879..890
FT /note="9; approximate"
FT REPEAT 901..910
FT /note="10"
FT REPEAT 911..920
FT /note="11"
FT REPEAT 921..930
FT /note="12"
FT REPEAT 931..940
FT /note="13"
FT REPEAT 941..950
FT /note="14"
FT REPEAT 951..960
FT /note="15; approximate"
FT REPEAT 961..970
FT /note="16"
FT REPEAT 971..980
FT /note="17"
FT REPEAT 981..990
FT /note="18"
FT REPEAT 991..1000
FT /note="19"
FT REPEAT 1001..1010
FT /note="20"
FT REPEAT 1011..1020
FT /note="21"
FT REPEAT 1021..1030
FT /note="22; approximate"
FT REPEAT 1031..1040
FT /note="23"
FT REPEAT 1041..1050
FT /note="24"
FT REPEAT 1051..1060
FT /note="25"
FT REPEAT 1061..1070
FT /note="26"
FT REPEAT 1071..1080
FT /note="27; approximate"
FT REPEAT 1081..1090
FT /note="28; approximate"
FT REPEAT 1091..1100
FT /note="29"
FT REPEAT 1101..1110
FT /note="30"
FT REPEAT 1111..1120
FT /note="31"
FT REPEAT 1121..1130
FT /note="32"
FT REPEAT 1131..1140
FT /note="33"
FT REPEAT 1141..1150
FT /note="34"
FT REPEAT 1151..1160
FT /note="35"
FT REPEAT 1161..1170
FT /note="36"
FT REPEAT 1171..1180
FT /note="37; approximate"
FT REPEAT 1181..1190
FT /note="38; approximate"
FT REPEAT 1191..1200
FT /note="39"
FT REPEAT 1201..1210
FT /note="40"
FT REPEAT 1211..1220
FT /note="41"
FT REPEAT 1221..1230
FT /note="42; approximate"
FT REPEAT 1231..1240
FT /note="43; approximate"
FT REPEAT 1241..1250
FT /note="44"
FT REPEAT 1251..1260
FT /note="45"
FT REPEAT 1261..1270
FT /note="46; approximate"
FT REPEAT 1271..1280
FT /note="47"
FT REPEAT 1281..1290
FT /note="48"
FT REPEAT 1291..1300
FT /note="49"
FT REPEAT 1301..1310
FT /note="50; approximate"
FT REPEAT 1311..1320
FT /note="51"
FT REPEAT 1321..1330
FT /note="52; approximate"
FT REPEAT 1331..1340
FT /note="53; approximate"
FT REPEAT 1341..1350
FT /note="54; approximate"
FT REPEAT 1351..1360
FT /note="55; approximate"
FT REPEAT 1361..1370
FT /note="56; approximate"
FT REPEAT 1371..1380
FT /note="57; approximate"
FT REPEAT 1381..1390
FT /note="58; approximate"
FT REPEAT 1391..1400
FT /note="59; approximate"
FT REPEAT 1401..1410
FT /note="60; approximate"
FT REPEAT 1411..1420
FT /note="61; approximate"
FT REPEAT 1421..1430
FT /note="62; approximate"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..1430
FT /note="62 X 10 AA approximate tandem repeats"
FT REGION 1342..1365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..469
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_053937"
FT VAR_SEQ 16..412
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_053938"
FT VAR_SEQ 663..705
FT /note="ARAQMGIGEEAVAGPWNWDDMDIDCLTREELGDDAQAWSRFSF -> IYSPC
FT LQIPLINCSSPSHGAKVHPWNLCPHSSQGSYGQSAEGVM (in isoform 2 and
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043513"
FT VAR_SEQ 706..1431
FT /note="Missing (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043514"
FT VARIANT 65
FT /note="R -> W (in dbSNP:rs60674633)"
FT /id="VAR_062122"
FT VARIANT 738
FT /note="S -> G (in dbSNP:rs17297490)"
FT /evidence="ECO:0000269|PubMed:10470851"
FT /id="VAR_053510"
FT VARIANT 951
FT /note="G -> S (in dbSNP:rs1211752617)"
FT /evidence="ECO:0000269|PubMed:23092983"
FT /id="VAR_076264"
FT CONFLICT 747
FT /note="S -> T (in Ref. 5; AAA79334)"
FT /evidence="ECO:0000305"
FT CONFLICT 768
FT /note="S -> G (in Ref. 1; BAA83066)"
FT /evidence="ECO:0000305"
FT CONFLICT 812
FT /note="S -> G (in Ref. 1; BAA83066)"
FT /evidence="ECO:0000305"
FT CONFLICT 824
FT /note="S -> G (in Ref. 1; BAA83066)"
FT /evidence="ECO:0000305"
FT CONFLICT 1026
FT /note="N -> G (in Ref. 1; BAA83066)"
FT /evidence="ECO:0000305"
FT CONFLICT 1056
FT /note="S -> G (in Ref. 1; BAA83066)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1431 AA; 143716 MW; 00FB9BFAC34A1699 CRC64;
MDRRNDYGYR VPLFQGPLPP PGSLGLPFPP DIQTETTEED SVLLMHTLLA ATKDSLAMDP
PVVNRPKKSK TKKAPIKTIT KAAPAAPPVP AANEIATNKP KITWQALNLP VITQISQALP
TTEVTNTQAS SVTAQPKKAN KMKRVTAKAA QGSQSPTGHE GGTIQLKSPL QVLKLPVISQ
NIHAPIANES ASSQALITSI KPKKASKAKK AANKAIASAT EVSLAATATH TATTQGQITN
ETASIHTTAA SIRTKKASKA RKTIAKVINT DTEHIEALNV TDAATRQIEA SVVAIRPKKS
KGKKAASRGP NSVSEISEAP LATQIVTNQA LAATLRVKRG SRARKAATKA RATESQTPNA
DQGAQAKIAS AQTNVSALET QVAAAVQALA DDYLAQLSLE PTTRTRGKRN RKSKHLNGDE
RSGSNYRRIP WGRRPAPPRD VAILQERANK LVKYLLVKDQ TKIPIKRSDM LRDVIQEYDE
YFPEIIERAS YTLEKMFRVN LKEIDKQSSL YILISTQESS AGILGTTKDT PKLGLLMVIL
SVIFMNGNKA SEAVIWEVLR KLGLRPGVRH SLFGEVRKLI TDEFVKQKYL EYKRVPNSRP
PEYEFFWGLR SYHETSKMKV LKFACRVQKK DPKDWAVQYR EAVEMEVQAA AVAVAEAEAR
AEARAQMGIG EEAVAGPWNW DDMDIDCLTR EELGDDAQAW SRFSFEIEAR AQENADASTN
VNFSRGASTR AGFSDGASIS FNGAPSSSGG FSGGPGITFG VAPSTSASFS NTASISFGGT
LSTSSSFSSA ASISFGCAHS TSTSFSSEAS ISFGGMPCTS ASFSGGVSSS FSGPLSTSAT
FSGGASSGFG GTLSTTAGFS GVLSTSTSFG SAPTTSTVFS SALSTSTGFG GILSTSVCFG
GSPSSSGSFG GTLSTSICFG GSPCTSTGFG GTLSTSVSFG GSSSTSANFG GTLSTSICFD
GSPSTGAGFG GALNTSASFG SVLNTSTGFG GAMSTSADFG GTLSTSVCFG GSPGTSVSFG
SALNTNAGYG GAVSTNTDFG GTLSTSVCFG GSPSTSAGFG GALNTNASFG CAVSTSASFS
GAVSTSACFS GAPITNPGFG GAFSTSAGFG GALSTAADFG GTPSNSIGFG AAPSTSVSFG
GAHGTSLCFG GAPSTSLCFG SASNTNLCFG GPPSTSACFS GATSPSFCDG PSTSTGFSFG
NGLSTNAGFG GGLNTSAGFG GGLGTSAGFS GGLSTSSGFD GGLGTSAGFG GGPGTSTGFG
GGLGTSAGFS GGLGTSAGFG GGLVTSDGFG GGLGTNASFG STLGTSAGFS GGLSTSDGFG
SRPNASFDRG LSTIIGFGSG SNTSTGFTGE PSTSTGFSSG PSSIVGFSGG PSTGVGFCSG
PSTSGFSGGP STGAGFGGGP NTGAGFGGGP STSAGFGSGA ASLGACGFSY G
