ID   BZLF1_EBVA8             Reviewed;         245 AA.
AC   Q1HVG1;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Trans-activator protein BZLF1;
DE            Short=EB1;
DE   AltName: Full=Zebra;
GN   ORFNames=BZLF1;
OS   Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=82830;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16490228; DOI=10.1016/j.virol.2006.01.015;
RA   Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.;
RT   "The genome of Epstein-Barr virus type 2 strain AG876.";
RL   Virology 350:164-170(2006).
CC   -!- FUNCTION: Plays a key role in the switch from latent infection to lytic
CC       cycle producing new virions. Acts as a transcription factor, inducing
CC       early lytic cycle genes, and as a origin binding protein for genome
CC       replication. BZLF1 activates the promoter of another EBV gene
CC       (BSLF2+BMLF1). {ECO:0000250|UniProtKB:P03206}.
CC   -!- SUBUNIT: Homodimer. Interacts with human UBN1, CRTC2 and RACK1.
CC       Interacts (via N-terminus) with human PAX5 (via N-terminus); this
CC       interaction inhibits BZLF1-mediated lytic viral reactivation.
CC       {ECO:0000250|UniProtKB:P03206}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P03206}.
CC   -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR   EMBL; DQ279927; ABB89248.1; -; Genomic_DNA.
DR   RefSeq; YP_001129467.1; NC_009334.1.
DR   SMR; Q1HVG1; -.
DR   PRIDE; Q1HVG1; -.
DR   GeneID; 5176210; -.
DR   KEGG; vg:5176210; -.
DR   Proteomes; UP000007639; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR017339; Trans-activator_BZLF1_HHV-4.
DR   PIRSF; PIRSF037966; BZLF1; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Early protein;
KW   G0/G1 host cell cycle checkpoint dysregulation by virus; Host nucleus;
KW   Host-virus interaction; Modulation of host cell cycle by virus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..245
FT                   /note="Trans-activator protein BZLF1"
FT                   /id="PRO_0000408267"
FT   DOMAIN          178..228
FT                   /note="bZIP"
FT   REGION          140..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..195
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000250"
FT   REGION          196..228
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   245 AA;  26776 MW;  62F18425EA112D99 CRC64;
     MMDPNSTSED VKFTPDPYQV PFVQAFDQAT RVYQDLGGPS QAPLPCVLWP VLPEPLPQGQ
     LTAYHVSAAP TGSWFPAPQP APENAYQAYA APQLFPVSDI TQNQQTNQAG GEAPQPGDNS
     TVQPAAAVVF ACPGANQGQQ LADIGAPQPA PAAAPARRTR KPLQPESLEE CDSELDIKRY
     KNRVASRKCR AKFKHLLQHY REVASAKSSE NDRLRLLLKQ MCPSLDVDSI IPRTPDVLHE
     DLLNF