TRP3_ARATH
ID TRP3_ARATH Reviewed; 619 AA.
AC Q9C7B1; Q5QKS3; Q9LHB0;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Telomere repeat-binding protein 3;
DE AltName: Full=Protein TRF-LIKE 9;
DE AltName: Full=Telomeric DNA-binding protein 2;
DE Short=AtTBP2;
GN Name=TRP3; Synonyms=TBP2, TRFL9; OrderedLocusNames=At3g12560;
GN ORFNames=T2E22.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Chen C.M., Wang C.T., Kao Y.-H., Chang G.-D., Ho C.-H., Lee F.-M.,
RA Hseu M.-J.;
RT "Functional redundancy of the duplex telomeric DNA-binding proteins in
RT Arabidopsis.";
RL Bot. Bull. Acad. Sin. 46:315-324(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP GENE FAMILY, DNA-BINDING, TISSUE SPECIFICITY, AND SUBUNIT.
RX PubMed=15364931; DOI=10.1074/jbc.m407938200;
RA Karamysheva Z.N., Surovtseva Y.V., Vespa L., Shakirov E.V., Shippen D.E.;
RT "A C-terminal Myb extension domain defines a novel family of double-strand
RT telomeric DNA-binding proteins in Arabidopsis.";
RL J. Biol. Chem. 279:47799-47807(2004).
RN [9]
RP FUNCTION, DNA-BINDING, AND TISSUE SPECIFICITY.
RX PubMed=15688221; DOI=10.1007/s00438-004-1096-3;
RA Hwang M.G., Kim K., Lee W.K., Cho M.H.;
RT "AtTBP2 and AtTRP2 in Arabidopsis encode proteins that bind plant telomeric
RT DNA and induce DNA bending in vitro.";
RL Mol. Genet. Genomics 273:66-75(2005).
RN [10]
RP GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
CC -!- FUNCTION: Binds specifically to the plant telomeric double-stranded DNA
CC sequences. At least 2 repeats of telomeric sequences are required for
CC binding. Induces DNA bending. {ECO:0000269|PubMed:15688221}.
CC -!- SUBUNIT: Homodimer and heterodimer with TRP1.
CC {ECO:0000269|PubMed:15364931}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously. Highest expression in
CC flowers and roots. {ECO:0000269|PubMed:15364931,
CC ECO:0000269|PubMed:15688221}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB02267.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY181997; AAO61583.1; -; mRNA.
DR EMBL; AY550302; AAS58513.1; -; mRNA.
DR EMBL; AC069474; AAG51038.1; -; Genomic_DNA.
DR EMBL; AP002055; BAB02267.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE75213.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65523.1; -; Genomic_DNA.
DR EMBL; BT006452; AAP21260.1; -; mRNA.
DR EMBL; AK227790; BAE99772.1; -; mRNA.
DR RefSeq; NP_001327482.1; NM_001338001.1.
DR RefSeq; NP_187862.1; NM_112091.4.
DR AlphaFoldDB; Q9C7B1; -.
DR SMR; Q9C7B1; -.
DR BioGRID; 5770; 6.
DR STRING; 3702.AT3G12560.1; -.
DR PaxDb; Q9C7B1; -.
DR PRIDE; Q9C7B1; -.
DR ProteomicsDB; 232408; -.
DR EnsemblPlants; AT3G12560.1; AT3G12560.1; AT3G12560.
DR EnsemblPlants; AT3G12560.2; AT3G12560.2; AT3G12560.
DR GeneID; 820436; -.
DR Gramene; AT3G12560.1; AT3G12560.1; AT3G12560.
DR Gramene; AT3G12560.2; AT3G12560.2; AT3G12560.
DR KEGG; ath:AT3G12560; -.
DR Araport; AT3G12560; -.
DR TAIR; locus:2101232; AT3G12560.
DR eggNOG; ENOG502QS01; Eukaryota.
DR HOGENOM; CLU_020710_2_0_1; -.
DR InParanoid; Q9C7B1; -.
DR OMA; EVNNHES; -.
DR OrthoDB; 302274at2759; -.
DR PhylomeDB; Q9C7B1; -.
DR PRO; PR:Q9C7B1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9C7B1; baseline and differential.
DR Genevisible; Q9C7B1; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008301; F:DNA binding, bending; IDA:TAIR.
DR GO; GO:0042162; F:telomeric DNA binding; IDA:TAIR.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR031105; TRP_plant.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR21717; PTHR21717; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..619
FT /note="Telomere repeat-binding protein 3"
FT /id="PRO_0000394126"
FT DOMAIN 324..403
FT /note="Ubiquitin-like"
FT DOMAIN 504..563
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 532..559
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 593..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 402
FT /note="E -> G (in Ref. 1; AAO61583)"
FT /evidence="ECO:0000305"
FT CONFLICT 529
FT /note="T -> A (in Ref. 1; AAO61583)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 619 AA; 68759 MW; 81F201A1D763D353 CRC64;
MVFKRKLDCL SVGFDFPNIP RAPRSCRRKV LNKRIDHDDD NTQICAIDLL ALAGKILQES
ESSSASSNAF EEIKQEKVEN CKTIKSESSD QGNSVSKPTY DISTEKCVVN SCFSFPDSDG
VLERTPMSDY KKIHGLMDVG CENKNVNNGF EQGEATDRVG DGGLVTDTCN LEDATALGLQ
FPKSVCVGGD LKSPSTLDMT PNGSYARHGN HTNLGRKDDD EKFYSYHKLS NKFKSYRSPT
IRRIRKSMSS KYWKQVPKDF GYSRADVGVK TLYRKRKSCY GYNAWQREII YKRRRSPDRS
SVVTSDGGLS SGSVSKLPKK GDTVKLSIKS FRIPELFIEV PETATVGSLK RTVMEAVSVL
LSGGIRVGVL MHGKKVRDER KTLSQTGISC DENLDNLGFT LEPSPSKVPL PLCSEDPAVP
TDPTSLSERS AASPMLDSGI PHADDVIDSR NIVDSNLELV PYQGDISVDE PSSDSKELVP
LPELEVKALA IVPLNQKPKR TELAQRRTRR PFSVTEVEAL VQAVEELGTG RWRDVKLRAF
EDADHRTYVD LKDKWKTLVH TASISPQQRR GEPVPQELLD RVLRAYGYWS QHQGKHQARG
ASKDPDMNRG GAFESGVSV
