ID   TRP6_ARATH              Reviewed;         400 AA.
AC   Q9M347; F4JBM6;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Telomere repeat-binding protein 6;
DE   AltName: Full=Protein TRF-LIKE 4;
GN   Name=TRP6; Synonyms=TRFL4; OrderedLocusNames=At3g53790; ORFNames=F5K20.90;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, DNA-BINDING, TISSUE SPECIFICITY, SUBUNIT, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=15364931; DOI=10.1074/jbc.m407938200;
RA   Karamysheva Z.N., Surovtseva Y.V., Vespa L., Shakirov E.V., Shippen D.E.;
RT   "A C-terminal Myb extension domain defines a novel family of double-strand
RT   telomeric DNA-binding proteins in Arabidopsis.";
RL   J. Biol. Chem. 279:47799-47807(2004).
CC   -!- FUNCTION: Binds specifically to the plant telomeric double-stranded DNA
CC       sequences. At least 4 repeats of telomeric sequences are required for
CC       binding.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:15364931}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously.
CC       {ECO:0000269|PubMed:15364931}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype, probably due to redundancy.
CC       {ECO:0000269|PubMed:15364931}.
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DR   EMBL; AL132960; CAB88341.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE79144.2; -; Genomic_DNA.
DR   PIR; T45919; T45919.
DR   RefSeq; NP_001319741.1; NM_001339633.1.
DR   AlphaFoldDB; Q9M347; -.
DR   SMR; Q9M347; -.
DR   BioGRID; 9863; 1.
DR   PRIDE; Q9M347; -.
DR   GeneID; 824546; -.
DR   KEGG; ath:AT3G53790; -.
DR   Araport; AT3G53790; -.
DR   InParanoid; Q9M347; -.
DR   OrthoDB; 302274at2759; -.
DR   PhylomeDB; Q9M347; -.
DR   PRO; PR:Q9M347; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9M347; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042162; F:telomeric DNA binding; IEA:UniProt.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR031105; TRP_plant.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR21717; PTHR21717; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM00717; SANT; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS51294; HTH_MYB; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..400
FT                   /note="Telomere repeat-binding protein 6"
FT                   /id="PRO_0000394129"
FT   DOMAIN          173..252
FT                   /note="Ubiquitin-like"
FT   DOMAIN          310..369
FT                   /note="HTH myb-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   DNA_BIND        338..365
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT   CONFLICT        267
FT                   /note="F -> L (in Ref. 2; AEE79144)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   400 AA;  45033 MW;  624DF554C1E9951D CRC64;
     MVDCGVDIYQ LPVVPRACRS PRGRRLKIMR KQRSEFEVLA QVAGRFSGER KNRIVIGSLA
     HETKETKDDN VVVNNFLETM EVEVKPQPGL ENLSQVLLSK DWLALGPSMP NSPITQEENF
     DSRSKIDSKR KVSHLKERGS CISQESQNMY PLKKRKLFYQ NHSSESHDTP CTVKFGIKSL
     NISELLVDVP ESATVGSLKL AVLEAVTQIL KGGLNIGVLF QGKTIVDDSK TLLQIGIPYD
     DDDDENLGSL GFMLEPQKSE TTTITTFTTV SPRTRLRQNQ VLGSVDSTEA VAAKSVVPVR
     MKPAWQPEMV QRRIRRPFTV SEVEALVQAV ERLGTGRWRD VKSHAFNHVN HRTYVDLKDK
     WKTLVHTAKI SARQRRGEPV PQDLLDRVLA AHAFWSDRTG