TRPA1_CAEEL
ID TRPA1_CAEEL Reviewed; 1211 AA.
AC Q18297;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 5.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Transient receptor potential cation channel subfamily A member 1 homolog;
GN Name=trpa-1; ORFNames=C29E6.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=17450139; DOI=10.1038/nn1886;
RA Kindt K.S., Viswanath V., Macpherson L., Quast K., Hu H., Patapoutian A.,
RA Schafer W.R.;
RT "Caenorhabditis elegans TRPA-1 functions in mechanosensation.";
RL Nat. Neurosci. 10:568-577(2007).
CC -!- FUNCTION: Receptor-activated non-selective cation channel involved in
CC the nose-touch response and foraging behavior. Contributes to the
CC neural responses of sensory neurons to touch, particularly after
CC repeated mechanical stimulation. Has no apparent role in thermosensory
CC or chemosensory behaviors. {ECO:0000269|PubMed:17450139}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:O75762}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17450139};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in many sensory neurons, including OLQ
CC and IL1 neurons. {ECO:0000269|PubMed:17450139}.
CC -!- DISRUPTION PHENOTYPE: Worms exhibit specific defects in mechanosensory
CC behaviors: abnormal head withdrawal reflex, defective reversal behavior
CC in response to nose-touch and foraging behaviors.
CC {ECO:0000269|PubMed:17450139}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=The power behind pain
CC - Issue 82 of May 2007;
CC URL="https://web.expasy.org/spotlight/back_issues/082";
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DR EMBL; Z72504; CAA96603.3; -; Genomic_DNA.
DR PIR; T19552; T19552.
DR RefSeq; NP_502249.3; NM_069848.4.
DR AlphaFoldDB; Q18297; -.
DR SMR; Q18297; -.
DR BioGRID; 43213; 1.
DR DIP; DIP-61523N; -.
DR STRING; 6239.C29E6.2a; -.
DR TCDB; 1.A.4.6.5; the transient receptor potential ca(2+) channel (trp-cc) family.
DR EPD; Q18297; -.
DR PaxDb; Q18297; -.
DR EnsemblMetazoa; C29E6.2a.1; C29E6.2a.1; WBGene00007801.
DR GeneID; 178118; -.
DR KEGG; cel:CELE_C29E6.2; -.
DR UCSC; C29E6.2; c. elegans.
DR CTD; 178118; -.
DR WormBase; C29E6.2a; CE42588; WBGene00007801; trpa-1.
DR eggNOG; KOG0510; Eukaryota.
DR GeneTree; ENSGT00940000173888; -.
DR InParanoid; Q18297; -.
DR OMA; NLLFMIR; -.
DR OrthoDB; 602447at2759; -.
DR PhylomeDB; Q18297; -.
DR PRO; PR:Q18297; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00007801; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; Q18297; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
DR GO; GO:0097730; C:non-motile cilium; IDA:WormBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 4.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 17.
DR SUPFAM; SSF48403; SSF48403; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 9.
PE 2: Evidence at transcript level;
KW ANK repeat; Cell membrane; Coiled coil; Glycoprotein; Ion channel;
KW Ion transport; Membrane; Reference proteome; Repeat; Sensory transduction;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1211
FT /note="Transient receptor potential cation channel
FT subfamily A member 1 homolog"
FT /id="PRO_0000215372"
FT TOPO_DOM 1..811
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 812..832
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 833..870
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 871..891
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 892..894
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 895..915
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 916..932
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 933..953
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 954..975
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 976..996
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 997..1004
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT INTRAMEM 1005..1025
FT /note="Pore-forming"
FT /evidence="ECO:0000250|UniProtKB:O75762"
FT TOPO_DOM 1026..1048
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1049..1069
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1070..1193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 49..79
FT /note="ANK 1"
FT REPEAT 83..112
FT /note="ANK 2"
FT REPEAT 116..169
FT /note="ANK 3"
FT REPEAT 173..202
FT /note="ANK 4"
FT REPEAT 206..235
FT /note="ANK 5"
FT REPEAT 239..270
FT /note="ANK 6"
FT REPEAT 277..306
FT /note="ANK 7"
FT REPEAT 311..340
FT /note="ANK 8"
FT REPEAT 344..374
FT /note="ANK 9"
FT REPEAT 378..407
FT /note="ANK 10"
FT REPEAT 411..440
FT /note="ANK 11"
FT REPEAT 473..502
FT /note="ANK 12"
FT REPEAT 506..535
FT /note="ANK 13"
FT REPEAT 540..569
FT /note="ANK 14"
FT REPEAT 573..602
FT /note="ANK 15"
FT REPEAT 605..634
FT /note="ANK 16"
FT REPEAT 638..669
FT /note="ANK 17"
FT COILED 1149..1191
FT /evidence="ECO:0000255"
FT CARBOHYD 856
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 863
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1211 AA; 138450 MW; 6AB5A06F69097201 CRC64;
MSKKSLGLDV RLELEGLISN DDTIRSEKDG RQASIFRVAE LDARTEADNL RSIIHQSARE
GNVNALQEAL LKAPLAVNAQ DGDFMTPLHY AARYGNYDAV KLLLSKNALP NTKNREGDTP
LHIASKYIYG YSDICSIIDE DQADSARKYN TATKKIINAL VSENAEIDPV NKYQLTPLHY
AAMKSNFSAL HALIKLKADV DAEDDNKMTP LLLACVHGSQ EIIQELIKAN SNVTKRDQRL
NTVFHIVALR GEPEYLEMMM DHDPVEAIKA LNLFNNEKKT PLRMAVEGNH PETLKKILQM
EKKNSCKWMD REKELIHFAA EKGFLEVLKA LVEAGGNKNE LNEVKAVPLH VAAQMNQLEV
VSYLIEEEKD NIDVVDEQGL TPLMMAVTHD SKKCVEYLIA KKANLTITDK DERTPVFIGA
KFNALSSVEY ILDHLRKKNK ETERSALKSP TRNTLRIVSE DVRRTMVNMV DRDQNTPMHI
VASNGYLEMM QLLQKHGASI TQVNEDEETA LHRAAIGGQT GAVRQLLEWD IRLLLMKDEM
GNSALHLAAR SGHDATTKVL LDNGADKEAK NSYQKTPLQV AVDSGKLETC QRLVAKGAQI
ESSSDTKTVL HTAAFYGNES IVRYFIAEGV TIDRRDEEGK TAFDIACEND HKDVARAFLE
TDQWKNLMIP CDVIPLDKHR NPVNMKRRTP FRTLLTKFPE LASFVMDNCI EKSKEETDST
QSVAYNFEFL DDTYMMRCVS DDGTGEQLIG CKSAYDEDFK LEKDAQSYAS NYDRVYKYHP
LKLMADAEKL HLLNHPLSKA LLKYKWNRLG RPMYYFALFM YLVFIVSLTQ YVRHTKAPYN
VWNEESYYDS EYFDENETCP QINTTKPDVV WKIIIQTLAV CQILVECFQL FQRKFAYLVN
WENWIDCFIY STALITVYDF SECSATSGVR QNWQWILAAL CIFFGWINLL FMIRKMPRFG
IFVVMFVDIV KTFFRFFPVF VLFIIAFSSS FYVILQNRPE FSTIFMSPLK TTVMMIGEFE
FTGIFHGDET THAEKMFGPA HTAVACALFF FFCIIMTILL MNLLVGLAVD DIKGVQEKAE
LKRLAMQVDL VLQIEASLHF FIQRTKKYAT CRYATFPYGK LHKTGFAGWW SNFRRRFGLS
VSTDPEIDEM YEREAEFTSE MTQKLQNQAA KLKNIQENID VMYEKQVRLE AIIAKLATGL
NINIELEEKD N
